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dc.contributor.authorBaltacı, Saltuk Buğra
dc.contributor.authorGülbahçe Mutlu, Elif
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.date.accessioned2019-07-10T08:50:43Z
dc.date.available2019-07-10T08:50:43Z
dc.date.issued2018-10-30
dc.identifier.urihttps://hdl.handle.net/20.500.12498/1076
dc.description.abstractThe aim of the present study determines the effect of zinc and melatonin supplementation on IL-6 levels in female rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). Total 42 wistar female rats which was just weaned from milk equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+Zinc, Group 4 DMBA+Melatonin, Group 5 DMBA+Zinc+Melatonin. To induce breast cancer, the animals, except those in group 1, were administered 80 mg/kg of DMBA in colza oil (canola) through gavage. The groups which were supplemented with zinc and melatonin were introperitoneally given 5 mg/kg/day of zinc, melatonin and zinc+melatonin for 4 weeks. Blood samples were taken under general anesthesia to tube with EDTA, and IL-6 levels were determined by ELISA. The highest IL-6 levels were determined in the DMDA control group (p<0.05). DMBA + zinc and DMBA+ melatonin groups were had lower IL-6 levels compared to group 2 (p<0.05). Group 5 has the lowest IL-6 levels compared to all breast cancer induced groups (G 2,3,4) (p<0.05). The results of the present study indicate that increased IL-6 levels in breast cancer inhibites by zinc and melatonin. However, the most significant inhibition was seen in combine of zinc and melatonin (group 5). The combined administration of zinc + melatonin may contribute to the prevention of tumoral growth by suppressing IL-6 levels, which can accelerate cancer development.en_US
dc.language.isoenen_US
dc.publisherInternatıonal Academic Research Congress (INES-2018)en_US
dc.subjectDMBAen_US
dc.subjectbreast canceren_US
dc.subjectIL-6en_US
dc.subjectzincen_US
dc.subjectmelatoninen_US
dc.titleIncreased IL-6 Levels Inhibites by Zinc and Melatonin Support in Rats with Breast Cancer induced by DMBAen_US
dc.typeOtheren_US


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