The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on experimental brain ischemia-reperfusion in rats. The study was performed on the 34 male Wistar-albino rats, weigth 350-400 gr. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; 3-DiOHF+Ischemiareperfusion; 4-Ischemia+DiOHF+Reperfusion; 5- Ischemia-reperfusion+DiOHF. DiOHF was given to animals as 10 mg/kg by intraperitoneal. Cerebral cortex was analyzed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Tissue MDA levels were significantly higher ischemia-reperfusion groups (p<0.005). However, DiOHF inhibited MDA. Ischemiareperfusion led to increased XO and NO but DiOHF supplementation reduced NO and XO. DiOHF increased GSH and GPx levels compared to ischemia-reperfusion group. Our present study showed that intraperitoneal DiOHF supplementation has protective effect on brain ischaemi-reperfusion injury in rat.
Eser Adı (dc.title) | Cerebral Ischemia Reperfusion Injury in Rats: Effect of 3’,4’-Dihydroxyflavonol |
Yayın Türü (dc.type) | Konferans Bildirisi |
Yazar/lar (dc.contributor.author) | MOĞULKOÇ, Rasim |
Yazar/lar (dc.contributor.author) | BALTACI, Abdülkerim Kasım |
Yazar/lar (dc.contributor.author) | MENEVŞE, Esma |
Yazar/lar (dc.contributor.author) | BALTACI, Saltuk Buğra |
Yazar/lar (dc.contributor.author) | GÜLBAHÇE MUTLU, Elif |
Atıf Dizini (dc.source.database) | Diğer |
Konu Başlıkları (dc.subject) | Brain Ischaemia-Reperfusion |
Konu Başlıkları (dc.subject) | 3',4'-Dihydroxyflavonol |
Konu Başlıkları (dc.subject) | Free Radicals |
Konu Başlıkları (dc.subject) | Rat |
Yayıncı (dc.publisher) | Internatıonal Academic Research Congress (INES-2018) |
Yayın Tarihi (dc.date.issued) | 2018 |
Kayıt Giriş Tarihi (dc.date.accessioned) | 2019-07-10T08:51:41Z |
Açık Erişim tarihi (dc.date.available) | 2019-07-10T08:51:41Z |
Özet (dc.description.abstract) | The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on experimental brain ischemia-reperfusion in rats. The study was performed on the 34 male Wistar-albino rats, weigth 350-400 gr. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; 3-DiOHF+Ischemiareperfusion; 4-Ischemia+DiOHF+Reperfusion; 5- Ischemia-reperfusion+DiOHF. DiOHF was given to animals as 10 mg/kg by intraperitoneal. Cerebral cortex was analyzed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Tissue MDA levels were significantly higher ischemia-reperfusion groups (p<0.005). However, DiOHF inhibited MDA. Ischemiareperfusion led to increased XO and NO but DiOHF supplementation reduced NO and XO. DiOHF increased GSH and GPx levels compared to ischemia-reperfusion group. Our present study showed that intraperitoneal DiOHF supplementation has protective effect on brain ischaemi-reperfusion injury in rat. |
Yayın Dili (dc.language.iso) | en |
Tek Biçim Adres (dc.identifier.uri) | https://hdl.handle.net/20.500.12498/1078 |