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dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.contributor.authorMenevşe, Esma
dc.contributor.authorBaltacı, Saltuk Buğra
dc.contributor.authorGülbahçe Mutlu, Elif
dc.date.accessioned2019-07-10T08:51:41Z
dc.date.available2019-07-10T08:51:41Z
dc.date.issued2018-10-30
dc.identifier.urihttps://hdl.handle.net/20.500.12498/1078
dc.description.abstractThe aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on experimental brain ischemia-reperfusion in rats. The study was performed on the 34 male Wistar-albino rats, weigth 350-400 gr. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; 3-DiOHF+Ischemiareperfusion; 4-Ischemia+DiOHF+Reperfusion; 5- Ischemia-reperfusion+DiOHF. DiOHF was given to animals as 10 mg/kg by intraperitoneal. Cerebral cortex was analyzed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Tissue MDA levels were significantly higher ischemia-reperfusion groups (p<0.005). However, DiOHF inhibited MDA. Ischemiareperfusion led to increased XO and NO but DiOHF supplementation reduced NO and XO. DiOHF increased GSH and GPx levels compared to ischemia-reperfusion group. Our present study showed that intraperitoneal DiOHF supplementation has protective effect on brain ischaemi-reperfusion injury in rat.en_US
dc.language.isoenen_US
dc.publisherInternatıonal Academic Research Congress (INES-2018)en_US
dc.subjectbrain ischaemia-reperfusionen_US
dc.subject3',4'-dihydroxyflavonolen_US
dc.subjectfree radicalsen_US
dc.subjectRaten_US
dc.titleCerebral Ischemia Reperfusion Injury in Rats: Effect of 3’,4’-Dihydroxyflavonolen_US
dc.typeOtheren_US


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