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Bulunan: 10 Adet 0.001 sn
Koleksiyon : Tıp Fakültesi ✕İlgili Araştırmacılar : Tuğçe Duran ✕
Koleksiyon [2]
İlgili Araştırmacılar [6]
Ambargo Durumu [1]
Tam Metin [1]
Yayın Türü [4]
Yazar/lar [20]
Atıf Dizini [4]
Konu Başlıkları [20]
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Yayın Tarihi [6]
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dc.description.provenance [9]
Dr. Öğr. Üyesi Tuğçe DuranKTO KARATAY ÜNİVERSİTESİ/TIP FAKÜLTESİ/DAHİLİ TIP BİLİMLERİ BÖLÜMÜ/TIBBİ GENETİK ANABİLİM DALI/
Erişime Açık

A Case Report of Glanzman Thrombasthenia with Anterior Mediastinal Hematoma and Factor V Leiden Mutation

TOKGÖZ, Hüseyin | ÇALIŞKAN, Ümran | DURAN, Tuğçe | ÇALIŞKAN SAK, Kaniye Zeynep

Glanzmann thrombasthenia (GT) is an autosomal recessive disease associated with platelet aggregation dysfunction with normal platelet count, causing bleeding diathesis. GT is characterized by decreased levels or decreased function of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex and therefore results in an increased tendency to bleeding as the aggregation phase of primary hemostasis cannot be sufficiently formed. Factor V Leiden mutation is a genetic mutation predisposing to thrombophilia. We present this case in which Factor V Leiden mutation and Glanzmann thrombasthenia with hematoma in the ...Daha fazlası

Sunum 2023 KTO Karatay Üniversitesi Sağlık Bilimleri Dergisi 0 Görüntülenme
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Nadir Görülen Bir Vaka: Fanconi Aplastik Anemisi Gelişen Bir Klinefelter Sendromu Olgusu

TOKGÖZ, Hüseyin | ÇALIŞKAN, Ümran | DURAN, Tuğçe | ÇALIŞKAN SAK, Kaniye Zeynep

Giriş: Fankoni Aplastik Anemisi, çeşitli konjenital malformasyonlar, progresif pansitopeni ve genellikle hematolojik malignitelere yatkınlık ile karakterize genetik olarak çoğunlukla otozomal resesif olarak geçen bir hastalıktır. Konjenital anomaliler hastadan hastaya değişir ve başta iskelet malformasyonlarının yanı sıra ana organ sistemlerinden herhangi birini etkileyebilir. Klinefelter sendromu erkek hipogonadizminin en yaygın genetik formudur ve en sık görülen karyotip 47, XXY'dir. Vaka Sunumu: Halsizlik ve solukluk şikayetleri ile başvuran 9 yaşında erkek hastanın fizik muayenesinde kilo, ...Daha fazlası

Sunum 2022 KTO Karatay Üniversitesi Sağlık Bilimleri Dergisi 0 Görüntülenme
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Investigation of the effect of belinostat on MCF-7 breast cancer stem cells via the Wnt, Notch, and Hedgehog signaling pathway.

TUNCER, Zeliha | KURAR, Ercan | DURAN, Tugçe

Objectives: To evaluate belinostat’s (PXD101) activity on MCF-7 breast cancer stem cells (CSCs) via Wnt, Notch, and Hedgehog. Methods: This research study was carried out at the Department of Medical Biology, Necmettin Erbakan University, Konya, Turkey, from June 2017 to July 2019. The effect of PXD101 on MCF-7 cell viability was determined by cell proliferation kit (XTT). Following belinostat treatment, CD44+/ CD24- MCF-7 CSCs were isolated by FACS. Ribonucleic acid isolation and copy-deoxyribonucleic acid synthesis were carried out using HEK-293 cells, MCF-7 cells, and MCF-7 CSCs. Expression ...Daha fazlası

Makale 2024 Saudi Medical Journal45 ( 2 ) 0 Görüntülenme
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Subtype distribution and molecular characterization of Blastocystis from hemodialysis patients in Turkey.

GÜLHAN, Barış | AYDIN TERZİOĞLU, Merve | DEMİRKAZIK, Mehtap | KOLTAŞ, İsmail Soner | ÇIKMAN, Aytekin | TÜRKMEN, Kültigin | DURAN, Tuğçe

Introduction: The aim of this study was to determine the Blastocystis prevalence and subtypes in hemodialysis patients in Turkey. Methodology: Eighty-four patients diagnosed with end-stage renal failure who were undergoing hemodialysis and 20 healthy volunteers were enrolled. Blastocystis presence was investigated by native-Lugol, trichrome staining, PCR using STS primers, and DNA sequencing analysis. Results: Among the stool samples from the hemodialysis patients, 9.52% (8/84) were found to be Blastocystis-positive with the native-Lugol and trichrome staining. Seven of the eight Blastocystis ...Daha fazlası

Makale 2020 J Infect Dev Ctries 0 Görüntülenme
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In vitro antifungal and antibiofilm activities of novel sulfonyl hydrazone derivatives against Candida spp.

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | DURAN, Tuğçe | ÖZMEN, Ümmühan Özdemir | ŞUMLU, Esra | AYAN, Esra Bilen | KORUCU, Emine Nedime

Background: The aim of this study was to investigate the antifungal and antibiofilm activity of the new sulfonyl hydrazones compound derived from sulphonamides. Methods: In this study, new sulfonyl hydrazone series were synthesized via a green chemistry method. The structures of the synthesized compounds were characterized by elemental analyses and spectroscopic methods. The antifungal activities of the Anaf compounds against Candida strains under planktonic conditions were tested. The biofilm-forming ability of Candida strains was determined and the inhibitory effects of Anaf compounds on Can ...Daha fazlası

Makale 2023 J Mycol Med 0 Görüntülenme
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Effect of New Sulfonyl Hydrazone Compounds Against Candida Biofilms

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | DURAN, Tuğçe | ÖZDEMİR ÖZMEN, Ümmühan | ŞUMLU, Esra

Objectives: Candidiasis is the most frequently encountered fungal infection, with ranges from mild superficial infections to disseminated candidiasis. Most manifestations of Candidiasis are associated with biofilm formation. Candida biofilms contributes to therapeutic failure due to resistance to antimicrobial agents and causes an increase in mortality rates. For these reasons, finding new drugs and antimicrobial agents are urgently needed. Sulfonyl hydrazones derived from sulfonamide, are well-known for its pharmacological effects, such as antifungal, antibacterial potential activity. This st ...Daha fazlası

Konferans Bildirisi 2021 The Seventh International Mediterranean Symposium on Medicinal and Aromatic Plants MESMAP – 7 0 Görüntülenme
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Expression of Sap Genes 1-10 and Biofilm Formation in Candida Spp. Comparison of Healthcare Associated infectıon isolates from Bloodstream with Isolates from Other Sources

NSANGOU, Ahmed Moustapha | SAMADZADE, Rugiyya | DURAN, Tuğçe | MAÇİN, Salih | AYDIN TERZİOĞLU, Merve | FINDIK, Duygu

Candida species are yeast fungi that are common in nature and can cause both superficial and deep infections. According to recent data, Candida species are considered to be the main causative agents of healthcare-associated infections. In this study, it was aimed to determine Candida species, Sap genes and biofilm formation isolated from blood cultures, which are health care-associated infectious agents, and to evaluate them together with antifungal susceptibility tests. Candida spp. were identified by the Vitek 2 Compact method and then the results were verified by multiplex PCR and DNA seque ...Daha fazlası

Konferans Bildirisi 2022 3 rd International Eurasian Mycology Congress (EMC’22) 6 Görüntülenme
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In Vitro Antifungal and Antibiofilm Activity of Artemisinin Against Candida Species

AYDIN TERZİOĞLU, Merve | DURAN, Tuğçe | ŞUMLU, Esra

Artemisinin is a sesquiterpene lactone derivative of Artemisia annua L. Previous research has shown that artemisinin and its derivatives have important pharmacological properties. Candida species are opportunistic infections with high mortality and morbidity rates worldwide. There is growing evidence that natural agents have the ability to treat Candida infections. The demand for new drugs has increased in recent years due to treatment costs, toxicity and resistance to conventional antifungal drugs. The aim of this study was to investigate the antifungal and antibiofilm activity of artemisinin ...Daha fazlası

Konferans Bildirisi 2022 The Eighth International Mediterranean Symposium on Medicinal and Aromatic Plants-MESMAP-8 5 Görüntülenme
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Güncel COVID - 19 Bilgileri - 2021 (Lipid Nanoparçacık Tabanlı mRNA Aşı Teknolojisi ve SARS-CoV-2 (COVID-19) mRNA Aşıları)

DURAN, Tuğçe | AYDIN TERZİOĞLU, Merve | ÇİNE, Naci

ÖZET Nükleik asit tabanlı aşılar, hem canlı zayıflatılmış hem de alt birim aşıların olumlu özelliklerini birleştirmek için bir araç olarak geliştirilmektedir. Son yıllarda, mesajcı RNA (mRNA) aşıları, Şiddetli Akut Solunum Sendromu-Koronavirüs-2 (SARS-CoV-2)’ye karşı hem sıvısal hem de hücresel bağışık yanıtları uyandırmak için güvenli ve güçlü bir teknoloji olarak ortaya çıkmıştır. Küresel bir salgın haline gelen Koronavirüs hastalığı (COVID-19)’na karşı geliştirilen güçlü aşılar arasında mRNA tabanlı aşılar ilk başarılı aşı olarak kabul görmüştür. mRNA aşılarının üstün yanları; yüksek bağışı ...Daha fazlası

Kitap Bölümü 2021 Türkiye Klinikleri COVID - 19 5 Görüntülenme
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Effects Of Fentanyl On Pancreatic Cancer Cell Proliferation And Cancer Stem Cell Differentiation

ÇELİK, Feyzi | DURAN, Tuğçe

Pancreatic cancer is one of the most aggressive cancer due to the late diagnosis and failure to respond to the treatment despite advances in tumor biology and the development of new cancer therapeutic strategies. It has been reported that these characteristics of pancreatic cancer originate from cancer stem cells within the tumor mass. It has also been reported that Fentanyl is a fast-acting analgesic that binds to the mu-opioid receptors and some other mu-opioid receptors are involved in this cancer process. In this study, we determined the effect of Fentanyl on PANC-1 cells, by assessing the ...Daha fazlası

Makale 2019 10 Görüntülenme
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