|dc.contributor.author||Yildirim, T. and Okutan, O. and Akpinar, E. and Yilmaz, A. and Isik, H.
|dc.description.abstract||BACKGROUND AND OBJECTIVES: Human serum albumin (HA) is a unique
multifunctional protein with neuroprotective properties. We aimed to
delineate the mechanisms of HA-induced neuroprotection, supresses
inflammatory response and lipid peroxidation after spinal cord injury
METHODS AND STUDY DESIGN: Adult female Wistar rats weighing 210-250 g
were used for the study. The rats were randomly and blindly allocated
into five groups. The one-way analysis of variance (ANOVA) for
parametric data and Shapiro-Wilk test was used for evaluating the normal
distribution of the variables. Kruskal-Wallis for nonparametric data was
used to compare groups. Electron and light microscopies were used to
demonstrate ultrastructural changes in spinal cord.
RESULTS: The HA group was significantly different from all the other
groups (p < 0.05). Both MPSS and HA treatments decreased the MPO
significantly. HA treatment decreased the lipid peroxidation. HA
treatment prevented the worsening of clinical results. In the HA
treatment group, the ultrastructure was protected significantly. The
neuronal bodies and axonal structures were normal except for some
limited edematous spaces.
CONCLUSIONS: HA improves early clinical results, protects spinal cord
ultrastructure, and decreases MPO and LPO levels after spinal cord
|dc.source||BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY||
|dc.title||Neuroprotective effects of high-dose human albumin against traumatic
spinal cord injury in rats||