Among the most common causes of nasal congestion in childhood is adenoid hypertrophy (AH) which leads to hypoxia. In this study, we studied plasma concentrations of hypoxia induced factor-1α (HIF-1α) in children undergoing adenoidectomy. The study included a total of 86 participants: 39 patients with AH and 47 healthy individuals. Serum HIF-1α levels (ng/mL) were measured by ELISA. HIF-1α concentrations were compared to the adenoid-nasopharyngeal ratio (ANR) of patients with AH, as recorded in the medical records. We found significantly higher concentrations of HIF-1α (0.30 ± 0.47 ng/mL) in patients with AH as compared to healthy controls (0.24 ± 0.07 ng/mL, p = .011). HIF-1α levels were not significantly different regarding gender between patients with AH (p = .77) and in the control group (p = .97). In patients with AH, there was a moderately significant positive correlation between HIF-1α levels and Hb (p = .000), (correlation coefficient r = 0.542). There was a positive correlation between HIF-1α and ANR in patients with AH (p = .005, r = 0.439). This study indicates that AH increases HIF-1α levels. We also observed a moderately significant positive correlation between HIF-1α and ANR in patients with AH. HIF-1α levels are a potential biomarker for hypoxia in patients with AH.
Eser Adı (dc.title) | Hypoxia induced factor-1a levels in patients undergoing adenoidectomy |
Yayın Türü (dc.type) | Makale |
Yazar/lar (dc.contributor.author) | YÜCEL, Kamile |
Yazar/lar (dc.contributor.author) | AYDIN, İsa |
Yazar/lar (dc.contributor.author) | ERDEM, Said Sami |
Atıf Dizini (dc.source.database) | Wos |
Atıf Dizini (dc.source.database) | Scopus |
Konu Başlıkları (dc.subject) | Adenoids |
Konu Başlıkları (dc.subject) | Adenoidectomy |
Konu Başlıkları (dc.subject) | Hemoglobin |
Konu Başlıkları (dc.subject) | Hypertrophy |
Konu Başlıkları (dc.subject) | Hypoxia |
Konu Başlıkları (dc.subject) | Hypoxia-İnducible Factor-1 Alpha |
Konu Başlıkları (dc.subject) | Receiver Operating Characteristics |
Yayın Tarihi (dc.date.issued) | 2021 |
Kayıt Giriş Tarihi (dc.date.accessioned) | 2021-04-22T12:21:06Z |
Açık Erişim tarihi (dc.date.available) | 2021-04-22T12:21:06Z |
ISSN (dc.identifier.issn) | 0036-5513 |
Özet (dc.description.abstract) | Among the most common causes of nasal congestion in childhood is adenoid hypertrophy (AH) which leads to hypoxia. In this study, we studied plasma concentrations of hypoxia induced factor-1α (HIF-1α) in children undergoing adenoidectomy. The study included a total of 86 participants: 39 patients with AH and 47 healthy individuals. Serum HIF-1α levels (ng/mL) were measured by ELISA. HIF-1α concentrations were compared to the adenoid-nasopharyngeal ratio (ANR) of patients with AH, as recorded in the medical records. We found significantly higher concentrations of HIF-1α (0.30 ± 0.47 ng/mL) in patients with AH as compared to healthy controls (0.24 ± 0.07 ng/mL, p = .011). HIF-1α levels were not significantly different regarding gender between patients with AH (p = .77) and in the control group (p = .97). In patients with AH, there was a moderately significant positive correlation between HIF-1α levels and Hb (p = .000), (correlation coefficient r = 0.542). There was a positive correlation between HIF-1α and ANR in patients with AH (p = .005, r = 0.439). This study indicates that AH increases HIF-1α levels. We also observed a moderately significant positive correlation between HIF-1α and ANR in patients with AH. HIF-1α levels are a potential biomarker for hypoxia in patients with AH. |
Yayın Dili (dc.language.iso) | en |
Tek Biçim Adres (dc.identifier.uri) | http://hdl.handle.net/20.500.12498/5055 |