- Eklemek veya çıkarmak istediğiniz kriterleriniz için 'Dahil' / 'Hariç' seçeneğini kullanabilirsiniz. Sorgu satırları birbirine 'VE' bağlacı ile bağlıdır. - İptal tuşuna basarak normal aramaya dönebilirsiniz.
Introduction: Pancreas is a vital organ that produces metabolic hormones and enzymes. Any change in the function of this organ can directly affect the physiological mechanism in the body. Type II diabetes mellitus is a complex metabolic disease. And, this is emerged from either a failure in insulin secretion from pancreatic beta-cell cells or a decrease in pancreatic beta-cell mass. Despite the use of synthetic drugs in the treatment of metabolic diseases, many traditional plant therapies in the world are still used in the treatment of these diseases. The possible effects of grape seed extract ...Daha fazlası
Many types of aflatoxin cause problems for both public and animal health. Aflatoxin B1 (AFB1) is the most toxic and commonly encountered fungal toxin that appears in poultry feed and in feeds stored under unsuitable conditions. AFB1 decreases feed quality, egg production and fertility of hatching eggs. Also, AFB1 alters the development of embryos by infecting eggs. We investigated using sequence analysis the changes caused by different concentrations of AFB1 on the promoter sequences of the growth hormone regulated gene-1 (GHRG-1) in chick embryo at 13, 17, 19 and 21 days incubation. DNA isola ...Daha fazlası
Giriş: Kanser, hücre mitozunu kontrol eden genlerin mutasyona uğraması sonucunda hücrelerin kontrolsüz, aşırı ve hızlı bir şekilde çoğalmasına neden olan sistemik bir hastalıktır. Dünya çapındaki tüm yeni kanser teşhislerinin yaklaşık onda birini oluşturan meme kanseri ise, kadınlarda en sık görülen kanser tümörüdür. Metastaz yapma yeteneğine sahip olan tüm kanser hücreleri zamanla bütün organlara yayılabilmektedir. Kanser tedavisinde kullanılan kemoterapötik ilaçların yan etkileri de oldukça fazladır ve bu ilaçlar kanserli hücrelerin yanı sıra sağlıklı hücreleri de etkilemektedir. Bu nedenle ...Daha fazlası
Introduction: Diabetes mellitus is the most widespread and increasingly global prevalence and incidence, and is a chronic metabolic disorder resulting from insulin deficiency or insulin insufficiency. A consequence of this is chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism. In this study, soybean (Glycine max L.) seed extract in wistar rats created experimentally diabetic was aimed to investigate of the effects to some biochemical parameters (Urea, Creatinine, AST, ALT, Cholesterol, Triglycerides, Glucose, LDL, HDL, VLDL) and hyperglycemia. Material and Met ...Daha fazlası
The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on experimental brain ischemia-reperfusion in rats. The study was performed on the 34 male Wistar-albino rats, weigth 350-400 gr. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; 3-DiOHF+Ischemiareperfusion; 4-Ischemia+DiOHF+Reperfusion; 5- Ischemia-reperfusion+DiOHF. DiOHF was given to animals as 10 mg/kg by intraperitoneal. Cerebral cortex was analyzed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Tissue MDA level ...Daha fazlası
Aim of the study: Breast cancer is one of the most noticeable disease in women aged 20-59 years also it is expected to account for 30% of all new cancer diagnoses in women in 2016, Long-term use ofsoybean (Glycine max 1.) may prevent the progression of cancer. However, the molecular mechanism forthe functions of soybean remains unclear. So we decided to see how effective soybeans are on MCF-7Cell lines. Materials and Methods: Human breast cancer cell lines MCF-7 were treated with different concen-trations of methanol extract of soybean seeds. The growth rate was evaluated by XTT tests for 48 a ...Daha fazlası
In this study, it was aimed to investigate the effects of application of melatonin and zinc on lipid peroxidation and elemental metabolism in female rats with DMBA-induced mammary carcinoma. The study groups were composed of control, DMBA control and treatment (DMBA+ zinc, DMBA + melatonin and DMBA + zinc+melatonin) groups. Female rats (except the control group) were given a strong carcinogen DMBA. After tumour formation, zinc and melatonin were administered to the treatment groups at a dose of 5 mg/kg/day for 4 weeks. MDA as an indicator of tissue damage and GSH levels as an indicator of anti ...Daha fazlası
The aim of the present study determines the effect of zinc and melatonin supplementation on IL-6 levels in female rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). Total 42 wistar female rats which was just weaned from milk equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+Zinc, Group 4 DMBA+Melatonin, Group 5 DMBA+Zinc+Melatonin. To induce breast cancer, the animals, except those in group 1, were administered 80 mg/kg of DMBA in colza oil (canola) through gavage. The groups which were supplemented with zinc and melatonin were introperitone ...Daha fazlası
ABSTRACT: The aim of the present was study determine the effects of zinc and melatonin on brain tissue (cortex) lipid peroxidation in rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). Total 42 female wistar rats which was just weaned from milk equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+ Zinc, Group 4 DMBA + Melatonin, Group 5 DMBA + Zinc +Melatonin. To induce breast cancer 80 mg/kg DMBA was given by gavage in colza oil (except group 1). Zinc and melatonin were supplemented as 5 mg/kg/day for 4 weeks. Brain tissue samples (cortex) wer ...Daha fazlası
The aim of the present was study determine the effect of zinc and melatonin supplementation on lipid peroxidation of various tissues in female rats with breast cancer induced by DMBA (7,12- Dimethylbenz[a]anthracene). Total 42 Wistar albino female rats were equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+Zinc, Group 4 DMBA + Melatonin, Group 5 DMBA+Zinc+Melatonin. Lung, liver, spleen, pancreas and kidney tissue of rats were examined for MDA and GSH by spectrophotometric. The highest lung, liver, spleen, pancreas and kidney MDA levels were determined in group 2 ( ...Daha fazlası
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve cerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.