Effects Of Metformin On Estrous Cycle And Ovarian Hormones In Female Rats With Fructoseinduced Metabolic Syndrome

SUMLU, Esra | DEMIREL, Mürşide Ayse | DURMAZ KURŞUN, Ö. Ece | ULUDAĞ, M Orhan | ÖZERCAN, İ. Hanifi | ŞAHİN, Kazım | AKAR, Fatma

Over the last few decades, fructose consumption has dramatically increased in worldwide [1]. Growing evidence suggests that excessive fructose intake can also induce reproductive problems such as deterioration of oocyte quality and a decrease in estrogen level by disrupting follicular development and ovulation processes [2]. This study aimed to investigate the therapeutic effects of metformin on serum and ovarian reproductive hormone levels as well as ovarian cycle of rats with high-fructose diet induced metabolic syndrome. Female Wistar rats were divided into five groups as follows: control, ...Daha fazlası