MIPs and Aptamers for Recognition of Proteins in Biomimetic Sensing

MENGER, Marcus | YARMAN, Aysu | ERDŐSSY, Júlia | YILDIZ, Hüseyin Bekir | GYURCSÁNYI, Róbert Ervin | SCHELLER, Frieder Wolfram

Biomimetic binders and catalysts have been generated in order to substitute the biological pendants in separation techniques and bioanalysis. The two major approaches use either "evolution in the test tube" of nucleotides for the preparation of aptamers or total chemical synthesis for molecularly imprinted polymers (MIPs). The reproducible production of aptamers is a clear advantage, whilst the preparation of MIPs typically leads to a population of polymers with different binding sites. The realization of binding sites in the total bulk of the MIPs results in a higher binding capacity, however ...Daha fazlası

Makale 2016 2 Görüntülenme

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Folic-Acid-Modified Conducting Polymer: Electrochemical Detection of the Cell Attachment.

AZAK, Hacer | BARLAS, Fırat Barış | YILDIZ, Hüseyin Bekir | GÜLEÇ, Kadri | DEMİR, Bilal | ODACI DEMİRKOL, Dilek | TİMUR, Suna

Here, postfunctionalization and bioapplication of a π-conjugated polymer named 4-[4H-dithieno(3,2-b:2',3'-d)pyrrol-4-yl]aniline (DTP-aryl-NH2 ) are reported, which is successfully synthesized via electropolymerization onto the glassy carbon electrode. Folic acid (FA) is used to modify the amino functional polymer via N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide chemistry for the further steps. The selective adhesion of folate receptor positive cells on the surface is followed by the electrochemical methods. Cyclic voltammetry and electrochemical impedance s ...Daha fazlası

Makale 2016 7 Görüntülenme

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H Tipi Hidrolik Presin Modellenmesi Ve Konum Geri Beslemeli Oransal-Türevsel Kontrolü

TINKIR, Mustafa | SEZGEN, Haşmet Çağrı

In this study, modeling and position feedback proportional-derivative control of industrial 300 tons H-type hydraulic press is realized using a different modeling approach. In this modeling approach, obtaining of behavior of motion of whole system is aimed without using Newton, Lagrange and fluid dynamics equations. Firstly, mechanical motion of press is defined by importing solid model drawn in SolidWorks program to MATLAB/SimMechnanics program. Then obtained model is combined with hydraulic model designed in MATLAB/SimHydraulic program includes hydraulic power unit, valves, cylinders and oth ...Daha fazlası

Makale 2016 Deu Muhendislik Fakultesi Fen ve Muhendislik 6 Görüntülenme

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