- Eklemek veya çıkarmak istediğiniz kriterleriniz için 'Dahil' / 'Hariç' seçeneğini kullanabilirsiniz. Sorgu satırları birbirine 'VE' bağlacı ile bağlıdır. - İptal tuşuna basarak normal aramaya dönebilirsiniz.
TÜRKMEN, Kültigin | EROĞLU, Canan | ÇALIŞKAN SAK, Kaniye Zeynep | BALOĞLU, İsmail | KURAR, Ercan | KUTLU, Selim
Objective: The aim of this study was to determine serum asprosine levels in stage 3 and 4 chronic kidney disease (CKD) patients and healthy individuals and to investigate the relationship between this parameter and cardiovascular risk factors. Materials-Methods: In our investigation, serum and plasma samples from blood taken for standard laboratory testing were employed. In all, 91 people were involved in our investigation. Thirtyseven of these were patients with stage 3 CKD, twenty with stage 4 CKD, and 37 were healthy controls. Serum from both healthy and CKD participants was used to perform ...Daha fazlası
Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası
TÜRKOĞLU, Fatma Nur | ALPA, Şerife | GÜLBAHÇE MUTLU, Elif | ERBAYRAM, Fatma Zehra | ŞEFLEK, Hatice Nur
Background of the Study: Breast cancer, the second most common cause of cancer death, is a global public health problem due to its poor response to treatment and complex aetiology. The MCF-7 cell line is widely used in laboratories around the world for in vitro studies to address this problem. Diazepam is one of the most successful anaesthetics since the beginning of the psychopharmacological revolution. It belongs to a class of benzodiazepines that is often preferred in anaesthesia. Flumazenil is an imidazobenzodiazepine and was the first benzodiazepine antagonist to enter clinical use. The e ...Daha fazlası
ERBAYRAM, Fatma Zehra | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | TÜRKOĞLU, Fatma Nur | ŞEFLEK, Hatice Nur
Background of the Study: Breast cancer, a major cause of cancer-related deaths, is an important health problem due to its inadequate response to treatment and complex etiology. Oxytocin (OT) is a peptide mammalian hormone consisting of nine amino acids. Today, cellular studies of oxytocin have gained importance. Oxytocin has been observed to inhibit cell proliferation in cancer. The biggest advantage of oxytocin therapies is that they provide the organism with cell production on its own and have no side effects. Studies have shown that OT is a factor that stimulates cell proliferation in lung, ...Daha fazlası
Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası
ŞEFLEK, Hatice Nur | ERBAYRAM, Fatma Zehra | TOKAK, Semik
Infertility is a major health problem and is increasing worldwide. The shift in the age at which both partners have their first child to older ages and lifestyle changes have contributed to the increase in the incidence of infertility. 50% of infertility in couples is due to male infertility. In vitro studies show that bacteria can negatively affect sperm function. Bacteria; has been shown to play an important role in many mechanisms that affect sperm function, including agglutination of motile sperm, induction of apoptosis, production of immobilization factors, and disruption of acrosome resp ...Daha fazlası
Introduction: Hypothyroidism is an endocrine disorder that occurs mainly due to the insufficiency of thyroid hormones in the body or the inability of these hormones to affect target tissues. As a result of the insufficiency of thyroid hormones, the systems are affected and accordingly, the health status of individuals is adversely affected. Coenzyme Q10 is a lipophilic antioxidant that plays a role in membrane stability, energy conversion and ATP production. The aim of this study was to determine the effect of Coenzyme Q10 on GDNF, PLZF, SOX3 and THY1 gene expression levels in rats with hypoth ...Daha fazlası
Aim: In this study, it was aimed to determine the total phenolic content, flavonoid content, and antioxidant activity of Castanea sativa Mill. (chestnut) leaf extract and their anti-proliferative effect on MCF 7 cell line. Materials and Methods: It determined antioxidant capacities by using DPPH assay, total phenolic content by using Folin-Ciocaltaeu method and Total flavonoid content by aluminum chloride colorimetric method in the ethanolic extracts of Chesnut leaf. In addition, the anti-proliferative effect of chestnut leaf extract was determined by XTT method in MCF7 breast cell line. The l ...Daha fazlası
Objectives: To evaluate belinostat’s (PXD101) activity on MCF-7 breast cancer stem cells (CSCs) via Wnt, Notch, and Hedgehog. Methods: This research study was carried out at the Department of Medical Biology, Necmettin Erbakan University, Konya, Turkey, from June 2017 to July 2019. The effect of PXD101 on MCF-7 cell viability was determined by cell proliferation kit (XTT). Following belinostat treatment, CD44+/ CD24- MCF-7 CSCs were isolated by FACS. Ribonucleic acid isolation and copy-deoxyribonucleic acid synthesis were carried out using HEK-293 cells, MCF-7 cells, and MCF-7 CSCs. Expression ...Daha fazlası
Purpose: The aim of this study was to evaluate kallistatin levels in patients diagnosed with COVID-19 and compare them with healthy controls. Materials and Methods: A total of 40 patients diagnosed with COVID-19, and 45 healthy controls were included in the study. The patient group was divided into 2 groups: patients treated in the service (n:20) and patients treated in the intensive care unit (n:20). Kallistatin levels were measured using the ELISA method. Results: There was a significant difference in kallistatin levels between the patient group (n:40) and the control group (n:45). There was ...Daha fazlası
Introduction: The aim of this study was to determine the Blastocystis prevalence and subtypes in hemodialysis patients in Turkey. Methodology: Eighty-four patients diagnosed with end-stage renal failure who were undergoing hemodialysis and 20 healthy volunteers were enrolled. Blastocystis presence was investigated by native-Lugol, trichrome staining, PCR using STS primers, and DNA sequencing analysis. Results: Among the stool samples from the hemodialysis patients, 9.52% (8/84) were found to be Blastocystis-positive with the native-Lugol and trichrome staining. Seven of the eight Blastocystis ...Daha fazlası
KARAKOÇ, Hanife Nur | AKSOY, Aysun | AYDIN TERZİOĞLU, Merve | ÖZCAN, Safiye Nur | ZENGİN, Gülçin | AKŞİT YAŞAR, Hacer
Objective: To assess the effectiveness of high-dose corticosteroid pulse therapy and evaluate possible factors associated with 28-day mortality in hospitalised patients with severe COVID-19 pneumonia. Methods: We conducted a single-centre retrospective cohort study on hospitalised patients with clinical, epidemiological, and/or radiologically confirmed and suspected COVID-19 at Bitlis Tatvan State Hospital in Turkey between December 1, 2020 and June 1, 2021. All data of the study participants were recorded, and all patients received intravenous high-dose corticosteroid pulse therapy. The Ordin ...Daha fazlası
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve cerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.