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Cerebral Ischemia Reperfusion Injury in Rats: Effect of 3’,4’-Dihydroxyflavonol

MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım | MENEVŞE, Esma | BALTACI, Saltuk Buğra | GÜLBAHÇE MUTLU, Elif

The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on experimental brain ischemia-reperfusion in rats. The study was performed on the 34 male Wistar-albino rats, weigth 350-400 gr. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; 3-DiOHF+Ischemiareperfusion; 4-Ischemia+DiOHF+Reperfusion; 5- Ischemia-reperfusion+DiOHF. DiOHF was given to animals as 10 mg/kg by intraperitoneal. Cerebral cortex was analyzed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Tissue MDA level ...Daha fazlası

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The Effect of the Application of Melatonin and Zinc in DMBA-Induced Mammary Carcinoma in Rats on Lipid Peroxidation and Element Metabolism

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra | MENEVŞE, Esma | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

In this study, it was aimed to investigate the effects of application of melatonin and zinc on lipid peroxidation and elemental metabolism in female rats with DMBA-induced mammary carcinoma. The study groups were composed of control, DMBA control and treatment (DMBA+ zinc, DMBA + melatonin and DMBA + zinc+melatonin) groups. Female rats (except the control group) were given a strong carcinogen DMBA. After tumour formation, zinc and melatonin were administered to the treatment groups at a dose of 5 mg/kg/day for 4 weeks. MDA as an indicator of tissue damage and GSH levels as an indicator of anti ...Daha fazlası

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Increased IL-6 Levels Inhibites by Zinc and Melatonin Support in Rats with Breast Cancer induced by DMBA

BALTACI, Saltuk Buğra | GÜLBAHÇE MUTLU, Elif | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The aim of the present study determines the effect of zinc and melatonin supplementation on IL-6 levels in female rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). Total 42 wistar female rats which was just weaned from milk equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+Zinc, Group 4 DMBA+Melatonin, Group 5 DMBA+Zinc+Melatonin. To induce breast cancer, the animals, except those in group 1, were administered 80 mg/kg of DMBA in colza oil (canola) through gavage. The groups which were supplemented with zinc and melatonin were introperitone ...Daha fazlası

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Prevention of Increased Brain Cortex Damage by Zinc and Melatonin in Rats with Breast Cancer induced by DMBA

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

ABSTRACT: The aim of the present was study determine the effects of zinc and melatonin on brain tissue (cortex) lipid peroxidation in rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). Total 42 female wistar rats which was just weaned from milk equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+ Zinc, Group 4 DMBA + Melatonin, Group 5 DMBA + Zinc +Melatonin. To induce breast cancer 80 mg/kg DMBA was given by gavage in colza oil (except group 1). Zinc and melatonin were supplemented as 5 mg/kg/day for 4 weeks. Brain tissue samples (cortex) wer ...Daha fazlası

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The Effect of Support of Zinc and Melatonin on Lipid peroxidation of Various Tissues in Rats with Breast cancer induced by DMBA

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The aim of the present was study determine the effect of zinc and melatonin supplementation on lipid peroxidation of various tissues in female rats with breast cancer induced by DMBA (7,12- Dimethylbenz[a]anthracene). Total 42 Wistar albino female rats were equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+Zinc, Group 4 DMBA + Melatonin, Group 5 DMBA+Zinc+Melatonin. Lung, liver, spleen, pancreas and kidney tissue of rats were examined for MDA and GSH by spectrophotometric. The highest lung, liver, spleen, pancreas and kidney MDA levels were determined in group 2 ( ...Daha fazlası

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