The Effect Of Coenzyme Q10 Administration On The Expression Of Some Genes In Rats With Hypothroidia

ŞEFLEK, Hatice Nur | GÜLBAHÇE MUTLU, Elif | CÜCE, Gökhan | KALKAN, Serpil

Introduction: Hypothyroidism is an endocrine disorder that occurs mainly due to the insufficiency of thyroid hormones in the body or the inability of these hormones to affect target tissues. As a result of the insufficiency of thyroid hormones, the systems are affected and accordingly, the health status of individuals is adversely affected. Coenzyme Q10 is a lipophilic antioxidant that plays a role in membrane stability, energy conversion and ATP production. The aim of this study was to determine the effect of Coenzyme Q10 on GDNF, PLZF, SOX3 and THY1 gene expression levels in rats with hypoth ...Daha fazlası

Determination of Antioxidant and Anticancer Activities of C. Sativa Leaf Extracts on MCF7 Human Breast Cancer Cell Line

BEYAZYÜZ, Fadime | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur | KULAÇ, Şemsettin

Aim: In this study, it was aimed to determine the total phenolic content, flavonoid content, and antioxidant activity of Castanea sativa Mill. (chestnut) leaf extract and their anti-proliferative effect on MCF 7 cell line. Materials and Methods: It determined antioxidant capacities by using DPPH assay, total phenolic content by using Folin-Ciocaltaeu method and Total flavonoid content by aluminum chloride colorimetric method in the ethanolic extracts of Chesnut leaf. In addition, the anti-proliferative effect of chestnut leaf extract was determined by XTT method in MCF7 breast cell line. The l ...Daha fazlası

The Effects of Oil Price Shocks on Clean Energy and Oil and Gas Stock Returns

UÇKUN ÖZKAN, Ayşegül

This study empirically examines how fluctuations in oil prices affect the stock returns of clean energy and oil and gas companies between 2001:01 and 2022:06. Our results show that a negative oil supply shock affects the stock returns of clean energy companies positively. In contrast, an oil-specific demand shock negatively affects them. The findings also reveal that an increase in oil prices owing to an oil-specific demand shock tends not to improve the stock returns of oil and gas companies. Consequently, the results indicate that oil and clean energy are not alternatives.

The impact of investor attention on green bond returns: How do market uncertainties and investment performances of clean energy and oil and gas markets affect the connectedness between investor attention and green bond?

UÇKUN ÖZKAN, Ayşegül

This paper empirically investigates the spillover between investor attention and green bond returns by utilizing the connectedness approach. We will examine the impact of uncertainty in the stock, bond, and energy markets, as well as the success of clean energy, oil, and gas investments, on the relationship between green bonds and investor attention. We find that there are positive but small spillovers between investor attention and green bond returns. Besides, the connectedness between investor attention and green bond market performance is stronger in the short run than in the long run. Furt ...Daha fazlası

Sustainable supplier selection during micro crises in the manufacturing indutry: An application for the automotive spare parts indutry

ÇİZMECİOĞLU, Sinan | ÇALIK, Ahmet

Investigation of the effect of belinostat on MCF-7 breast cancer stem cells via the Wnt, Notch, and Hedgehog signaling pathway.

TUNCER, Zeliha | KURAR, Ercan | DURAN, Tugçe

Objectives: To evaluate belinostat’s (PXD101) activity on MCF-7 breast cancer stem cells (CSCs) via Wnt, Notch, and Hedgehog. Methods: This research study was carried out at the Department of Medical Biology, Necmettin Erbakan University, Konya, Turkey, from June 2017 to July 2019. The effect of PXD101 on MCF-7 cell viability was determined by cell proliferation kit (XTT). Following belinostat treatment, CD44+/ CD24- MCF-7 CSCs were isolated by FACS. Ribonucleic acid isolation and copy-deoxyribonucleic acid synthesis were carried out using HEK-293 cells, MCF-7 cells, and MCF-7 CSCs. Expression ...Daha fazlası

Plasma Kallistatin Levels in Patients with COVID-19

YÜCEL, Kamile | YILDIZ, Salih | GÜRBÜZ, Ali Fuat

Purpose: The aim of this study was to evaluate kallistatin levels in patients diagnosed with COVID-19 and compare them with healthy controls. Materials and Methods: A total of 40 patients diagnosed with COVID-19, and 45 healthy controls were included in the study. The patient group was divided into 2 groups: patients treated in the service (n:20) and patients treated in the intensive care unit (n:20). Kallistatin levels were measured using the ELISA method. Results: There was a significant difference in kallistatin levels between the patient group (n:40) and the control group (n:45). There was ...Daha fazlası

Subtype distribution and molecular characterization of Blastocystis from hemodialysis patients in Turkey.

GÜLHAN, Barış | AYDIN TERZİOĞLU, Merve | DEMİRKAZIK, Mehtap | KOLTAŞ, İsmail Soner | ÇIKMAN, Aytekin | TÜRKMEN, Kültigin | DURAN, Tuğçe

Introduction: The aim of this study was to determine the Blastocystis prevalence and subtypes in hemodialysis patients in Turkey. Methodology: Eighty-four patients diagnosed with end-stage renal failure who were undergoing hemodialysis and 20 healthy volunteers were enrolled. Blastocystis presence was investigated by native-Lugol, trichrome staining, PCR using STS primers, and DNA sequencing analysis. Results: Among the stool samples from the hemodialysis patients, 9.52% (8/84) were found to be Blastocystis-positive with the native-Lugol and trichrome staining. Seven of the eight Blastocystis ...Daha fazlası

Outcome of patients with severe COVID-19 pneumonia treated with high-dose corticosteroid pulse therapy A retrospective study

KARAKOÇ, Hanife Nur | AKSOY, Aysun | AYDIN TERZİOĞLU, Merve | ÖZCAN, Safiye Nur | ZENGİN, Gülçin | AKŞİT YAŞAR, Hacer

Objective: To assess the effectiveness of high-dose corticosteroid pulse therapy and evaluate possible factors associated with 28-day mortality in hospitalised patients with severe COVID-19 pneumonia. Methods: We conducted a single-centre retrospective cohort study on hospitalised patients with clinical, epidemiological, and/or radiologically confirmed and suspected COVID-19 at Bitlis Tatvan State Hospital in Turkey between December 1, 2020 and June 1, 2021. All data of the study participants were recorded, and all patients received intravenous high-dose corticosteroid pulse therapy. The Ordin ...Daha fazlası

Factors Affecting Adherence to Antiretroviral Treatment among HIV/AIDS Patients in Turkey

KARAKOÇ, Hanife Nur | KAYA, Selçuk | AYDIN TERZİOĞLU, Merve | KÖKSAL, İftihar

Introduction: Adherence to antiretroviral treatment (ART) is critical for the success of Human Immunodeficiency Virus (HIV) infection treatment. There is no approved consensus that defines adherence. In this study, it was aimed to examine the adherence rate of our patients with high-efficacy ART and to determine the factors affecting treatment adherence. Materials and Methods: Seventy-two patients admitted to the study between January 1, 2018 and July 31, 2018 with the diagnosis of HIV/AIDS who received ART for at least three months and agreed to participate in the study were included in the s ...Daha fazlası

Spatial Analysis of the Use of Iwan in Turkish Architecture from Central Asia to Anatolia

DAĞ GÜRCAN, Ayşenur | KARAMAĞARALI, C. Nakış

The iwan, whose use dates back to ancient times in Iran, Mesopotamia and Central Asia, is an architectural element with functional and semantic qualities and is usually seen on a monumental scale. At the same time, the iwan emphasizes the four-direction design within the Asian central space tradition, strengthens the centrality and carries symbolic value. The iwan, which has an important place in Turkish architecture due to these features, is an architectural element with historical continuity. In the process from Central Asia to Anatolia, it is observed that the iwan is seen in almost all kin ...Daha fazlası

Effect of New Sulfonyl Hydrazone Compounds Against Candida Biofilms

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | DURAN, Tuğçe | ÖZDEMİR ÖZMEN, Ümmühan | ŞUMLU, Esra

Objectives: Candidiasis is the most frequently encountered fungal infection, with ranges from mild superficial infections to disseminated candidiasis. Most manifestations of Candidiasis are associated with biofilm formation. Candida biofilms contributes to therapeutic failure due to resistance to antimicrobial agents and causes an increase in mortality rates. For these reasons, finding new drugs and antimicrobial agents are urgently needed. Sulfonyl hydrazones derived from sulfonamide, are well-known for its pharmacological effects, such as antifungal, antibacterial potential activity. This st ...Daha fazlası