The 21st Century Skills of Prep Students

TAYTAK ÜN, Gülberk

This descriptive study aims to investigate prep students’ perception of 21st Century Skills that have gained a great significance recently as a result of major developments in technology which has an impact on every field of life. These skills also required some innovations in the field of education, and Foreign Language education, which is based on communication, also includes some innovations as a natural consequence of this situation. While students of bachelor’s degree were expected to have only sufficient academic knowledge in the past, nowadays it’s a must for a person to have some quali ...Daha fazlası

Determination of Cytoxic Effects of Diazepam and Flumazenil in MCF-7 Cell Line

TÜRKOĞLU, Fatma Nur | ALPA, Şerife | GÜLBAHÇE MUTLU, Elif | ERBAYRAM, Fatma Zehra | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, the second most common cause of cancer death, is a global public health problem due to its poor response to treatment and complex aetiology. The MCF-7 cell line is widely used in laboratories around the world for in vitro studies to address this problem. Diazepam is one of the most successful anaesthetics since the beginning of the psychopharmacological revolution. It belongs to a class of benzodiazepines that is often preferred in anaesthesia. Flumazenil is an imidazobenzodiazepine and was the first benzodiazepine antagonist to enter clinical use. The e ...Daha fazlası

Determination Of Cytoxic Effects Of Oxytocin And Atosiban Mcf-7 Cell Line

ERBAYRAM, Fatma Zehra | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | TÜRKOĞLU, Fatma Nur | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, a major cause of cancer-related deaths, is an important health problem due to its inadequate response to treatment and complex etiology. Oxytocin (OT) is a peptide mammalian hormone consisting of nine amino acids. Today, cellular studies of oxytocin have gained importance. Oxytocin has been observed to inhibit cell proliferation in cancer. The biggest advantage of oxytocin therapies is that they provide the organism with cell production on its own and have no side effects. Studies have shown that OT is a factor that stimulates cell proliferation in lung, ...Daha fazlası

Determination of The Cytotoxic Effect of Propylthiouracil Loaded Mesoporous Silica on Mcf-7 Cell Line

GÜLBAHÇE MUTLU, Elif | ŞEFLEK, Hatice Nur | ALPA, Şerife | ERTUŞ, Emre Burak | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur

Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası

Semen Microbiome Dysbiosis In Male Infertility

ŞEFLEK, Hatice Nur | ERBAYRAM, Fatma Zehra | TOKAK, Semik

Infertility is a major health problem and is increasing worldwide. The shift in the age at which both partners have their first child to older ages and lifestyle changes have contributed to the increase in the incidence of infertility. 50% of infertility in couples is due to male infertility. In vitro studies show that bacteria can negatively affect sperm function. Bacteria; has been shown to play an important role in many mechanisms that affect sperm function, including agglutination of motile sperm, induction of apoptosis, production of immobilization factors, and disruption of acrosome resp ...Daha fazlası

The Effect Of Coenzyme Q10 Administration On The Expression Of Some Genes In Rats With Hypothroidia

ŞEFLEK, Hatice Nur | GÜLBAHÇE MUTLU, Elif | CÜCE, Gökhan | KALKAN, Serpil

Introduction: Hypothyroidism is an endocrine disorder that occurs mainly due to the insufficiency of thyroid hormones in the body or the inability of these hormones to affect target tissues. As a result of the insufficiency of thyroid hormones, the systems are affected and accordingly, the health status of individuals is adversely affected. Coenzyme Q10 is a lipophilic antioxidant that plays a role in membrane stability, energy conversion and ATP production. The aim of this study was to determine the effect of Coenzyme Q10 on GDNF, PLZF, SOX3 and THY1 gene expression levels in rats with hypoth ...Daha fazlası

Determination of Antioxidant and Anticancer Activities of C. Sativa Leaf Extracts on MCF7 Human Breast Cancer Cell Line

BEYAZYÜZ, Fadime | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur | KULAÇ, Şemsettin

Aim: In this study, it was aimed to determine the total phenolic content, flavonoid content, and antioxidant activity of Castanea sativa Mill. (chestnut) leaf extract and their anti-proliferative effect on MCF 7 cell line. Materials and Methods: It determined antioxidant capacities by using DPPH assay, total phenolic content by using Folin-Ciocaltaeu method and Total flavonoid content by aluminum chloride colorimetric method in the ethanolic extracts of Chesnut leaf. In addition, the anti-proliferative effect of chestnut leaf extract was determined by XTT method in MCF7 breast cell line. The l ...Daha fazlası

Sustainable supplier selection during micro crises in the manufacturing indutry: An application for the automotive spare parts indutry

ÇİZMECİOĞLU, Sinan | ÇALIK, Ahmet

Plasma Kallistatin Levels in Patients with COVID-19

YÜCEL, Kamile | YILDIZ, Salih | GÜRBÜZ, Ali Fuat

Purpose: The aim of this study was to evaluate kallistatin levels in patients diagnosed with COVID-19 and compare them with healthy controls. Materials and Methods: A total of 40 patients diagnosed with COVID-19, and 45 healthy controls were included in the study. The patient group was divided into 2 groups: patients treated in the service (n:20) and patients treated in the intensive care unit (n:20). Kallistatin levels were measured using the ELISA method. Results: There was a significant difference in kallistatin levels between the patient group (n:40) and the control group (n:45). There was ...Daha fazlası

Spatial Analysis of the Use of Iwan in Turkish Architecture from Central Asia to Anatolia

DAĞ GÜRCAN, Ayşenur | KARAMAĞARALI, C. Nakış

The iwan, whose use dates back to ancient times in Iran, Mesopotamia and Central Asia, is an architectural element with functional and semantic qualities and is usually seen on a monumental scale. At the same time, the iwan emphasizes the four-direction design within the Asian central space tradition, strengthens the centrality and carries symbolic value. The iwan, which has an important place in Turkish architecture due to these features, is an architectural element with historical continuity. In the process from Central Asia to Anatolia, it is observed that the iwan is seen in almost all kin ...Daha fazlası

Effect of New Sulfonyl Hydrazone Compounds Against Candida Biofilms

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | DURAN, Tuğçe | ÖZDEMİR ÖZMEN, Ümmühan | ŞUMLU, Esra

Objectives: Candidiasis is the most frequently encountered fungal infection, with ranges from mild superficial infections to disseminated candidiasis. Most manifestations of Candidiasis are associated with biofilm formation. Candida biofilms contributes to therapeutic failure due to resistance to antimicrobial agents and causes an increase in mortality rates. For these reasons, finding new drugs and antimicrobial agents are urgently needed. Sulfonyl hydrazones derived from sulfonamide, are well-known for its pharmacological effects, such as antifungal, antibacterial potential activity. This st ...Daha fazlası

Expression of Sap Genes 1-10 and Biofilm Formation in Candida Spp. Comparison of Healthcare Associated infectıon isolates from Bloodstream with Isolates from Other Sources

NSANGOU, Ahmed Moustapha | SAMADZADE, Rugiyya | DURAN, Tuğçe | MAÇİN, Salih | AYDIN TERZİOĞLU, Merve | FINDIK, Duygu

Candida species are yeast fungi that are common in nature and can cause both superficial and deep infections. According to recent data, Candida species are considered to be the main causative agents of healthcare-associated infections. In this study, it was aimed to determine Candida species, Sap genes and biofilm formation isolated from blood cultures, which are health care-associated infectious agents, and to evaluate them together with antifungal susceptibility tests. Candida spp. were identified by the Vitek 2 Compact method and then the results were verified by multiplex PCR and DNA seque ...Daha fazlası