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Background: The prevalence of opportunistic yeast infections has increased in recent decades as the resultof an increasing immunocompromised patient population.Aims: To evaluate ribosomal RNA (rRNA) gene sequence to identify medically important yeast species, toinvestigate the performance of both the rRNA gene internal transcribed spacer (ITS) and D1/D2 region in identifying clinically relevant yeasts, and to compare these results with those of a standard phenotypicmethod.Methods: Both regions from 50 yeast strains, comprising 45 clinical isolates and 5 reference strains, wereamplified using P ...Daha fazlası
AYDIN, Merve | YAZICI, Mustafa | DEMİRKAZIK, Mehtap | KOLTAŞ, İsmail Soner | ÇIKMAN, Aytekin | GÜLHAN, Barış | DURAN, Tuğçe | YILMAZ, Aysun | KARA, Murat
Objective: To investigate Blastocystis’ etiologic role and association with gastrointestinal symptomatology in acute and chronic urticaria patients and to identify Blastocystis subtypes responsible for urticaria. Methods: The study included urticaria patients and healthy individuals that presented to our polyclinic between June 2015 and May 2017. The participants were assigned into Group I (137 patients), subdivided into acute (72) and chronic urticaria patients (65), and Group II (129 control individuals). Blastocystis presence was investigated by native-Lugol examination, trichrome staining, ...Daha fazlası
ÇIKMAN, Aytekin | AYDIN, Merve | GÜLHAN, Barış | KARAKEÇİLİ, Faruk | KURTOĞLU, Muhammet Güzel | YÜKSEKKAYA, Şerife | PARLAK, Mehmet | GÜLTEPE, Sümbül Bilge | ÇOPUR ÇİÇEK, Ayşegül | BAYINDIR BİLMAN, Fulya | ÇİFTÇİ, İhsan Hakkı | KARA, Murat | ATMACA, Selahattin | ÖZEKİNCİ, Tuncer
tBackground: mecA is a predefined gene causing methicillin resistance in Staphylococcus aureus (S. aureus)isolates; however, it has been shown that some methicillin-resistant S. aureus (MRSA) strains do notcarry this gene. Recently, in isolates found to be MRSA-positive but mecA-negative, a new resistance gene called mecC, which is a homolog of mecA, has been reported. This study aimed to investigate the mecCand mecA genes in MRSA strains isolated from different geographic regions in Turkey.Methods: The sample of the study consisted of 494 MRSA strains isolated from seven geographical regionsi ...Daha fazlası
Mycobacterium cinsi, tümünün aside dirençli boyanma özelliği gösterdiği gram-pozitif basil türlerini içerir. Önemli bir tür olan Mycobacterium tuberculosis (MTB), Dickens zamanında tüketici, korkunç bir hastalık olarak nitelendirilen tüberküloz (verem) etkenidir. Çoğu zengin ülkeler dışında olmak üzere, tüberküloz, dünya nüfusunun hâlâ üçte birini enfekte etmekte ve her yıl yaklaşık 2 milyon kişinin ölümüne neden olmaktadır. Mycobacterium leprae, eski ve şekil bozucu bir hastalık olan lepra (cüzzam) etkenidir. Daha az patojenik olan çok sayıda tür ise, başta AIDS olmak üzere immün yetmezliği o ...Daha fazlası
MURFIN, Kristen E. | KELINBARD, Ruby | AYDIN, Merve | SALAZAR, Samuel A. | FIKRIG, Erol
Lyme disease is a common tick-borne infection caused by the spirochete Borrelia burgdorferi sensu stricto (s.s.). B. burgdorferi s.s. may utilize chemotaxis, the directional migration towards or away from a chemical stimulus, for transmission, acquisition, and infection. However, the specific signals recognized by the spirochete for these events have not been defined. In this study, we identify an Ixodes scapularis salivary gland protein, Salp12, that is a chemoattractant for the spirochete. We demonstrate that Salp12 is expressed in the I. scapularis salivary glands and midgut and expression ...Daha fazlası
ÖZTÜRK, Ali | AYDIN, Merve | ÖZDEMİR ÖZMEN, Ümmühan
Candida species cause cutaneous and systemic infections with a high mortality rate, especially in immunocompromised patients. However, the emergence of resistance to the most common antifungal drugs, also due to biofilm formation, there is an increasing need to design new and more effective antifungals with less toxic. Sulfonyl hydrazones are well-known for their pharmacological effects, such as antifungal and antibacterial potential and can act as an antinociceptive, antidepressant, antineoplastic activity. The aim of this study was to investigate the anti-candidal and anti-biofilm activity o ...Daha fazlası
AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | ÖZDEMİR ÖZMEN, Ümmühan
The prevalence of fungal infections has increased in the last two decades in parallel with the increasing number of immunosuppressed patients. The excessive use of antifungal agents is causing the accumulation of multi-resistance phenotypes in many fungal strains. Consequently, new alternative agents to conventional antifungal agents are urgently needed to prevent the emergence of fungal resistance. Sulfonyl hydrazone derived from sulfonamide, are well-known for their pharmacological effects, such as antifungal, antibacterial potential, and antineoplastic activity. This study aimed to investig ...Daha fazlası
BOZKURT, Aliseydi | GÜRSUL, Cebrail | AYDIN, Merve | SAYAR, İlyas | KARABAKAN, Mehmet | ÇIKMAN, Aytekin
Aim: Recently, oxidative stress has been well known that it has especially important a role in benign prostatic hyperplasia, prostatitis, and prostate cancer. The present study has planned to estimate parameters of the oxidative stress and the antioxidant status in patients with benign prostatic hyperplasia, prostatitis and prostate cancer. Material and Method: For this aim totally fourty men with benign prostatic hyperplasia (n=14), prostatitis (n=15) and prostate cancer (n=11) without any other chronic disease, and who not use cigarettes and alcohol were subjected. Venous blood samples were ...Daha fazlası
SEZGİN, Muhammed | AYDIN, Merve | KARAKEÇİLİ, Faruk | ÇIKMAN, Aytekin | GÜLHAN, Barış | ARSLAN, Yusuf Kemal
Amaç: Asimetrik dimetilarginin (ADMA), nitrik oksit sentazın (NOS) ana endojen inhibitörüdür. NOS, konak savunmasında ve vasküler yapının sürdürülmesinde önemli rol oynamaktadır. Yüksek ADMA düzeylerinin endoteldis fonksiyonu ile ilişkili olduğu ve çeşitli hastalıklarda rol aldığı gösterilmiştir. Brucellaspp.’nin neden olduğu zoonoz bir hastalık olan bruselloz, vaskülopati olarak kendini gösterebilmektedir. Ancak, bruselloz ile ADMA arasındaki ilişki ile ilgili yeterli veri bulunmamaktadır. Çalışmamızın amacı bruselloz hastalarında ve kontrol grubunda ADMA düzeyinin araştırılmasıdır. Yöntemler ...Daha fazlası
AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | ÖZDEMİR ÖZMEN, Ummuhan
Candidiasis is the most frequently encountered fungal disease that ranges from mild mucosal infections to serious candidaemia and disseminated candidiasis. There are only limited classes of antifungal agents available for physicians to combat Candida infections. In addition, biofilm cells display phenotypic traits that resulting in enhanced resistance to antifungal drugs. Therefore, the limited option to combat fungal threat has raised the interest in seeking alternative antifungal compounds. The aim of this study was to investigate the antifungal and anti-biofilm activity of the new Sulfonyl ...Daha fazlası
KULHAN, Nur Gözde | KULHAN, Mehmet | AYDIN, Merve | NAYKİ, Ümit | NAYKİ, Cenk | ULUĞ, Paşa | ATA, Nahit | MERTOĞLU, Cuma | ÇIKMAN, Aytekin | SAYAR, İlyas | TÜRKLER, Can
Why most women can clear human papillomavirus (HPV) infections while others can develop permanent infections. The stimulation of immunotolerance of the immune system of the host by the persistent HPV infection may be the answer to this question. Interleukin-33 (IL-33) may play a role in the pathogenesis of HPV infection, this hypothesis was thought to be due to the rapid release of IL-33 from damaged cells following tissue damage, necrosis, and activation of the inflammasome. Thus, in this study, the role of IL33/suppressor of tumorigenicity 2 (ST2) was emphasized in HPV positive and HPV negat ...Daha fazlası
KARAKEÇİLİ, Faruk | ÇIKMAN, Aytekin | AYDIN, Merve | BİNAY, Umut Devrim | KESİK, Ozan Arif | ÖZÇİÇEK, Fatih
ackground & objectives : Crimean-Congo hemorrhagic fever (CCHF), an illness characterized by fever and hemorrhage, is caused by a CCHF virus (CCHFV). It is an important public health problem in Turkey. The objective of this study was to evaluate the demographic, clinical, and laboratory characteristics and mortality rates of CCHF patients in the northeast region of Turkey. Methods : A total of 206 patients, diagnosed with CCHF, from northeast region of Turkey were included and evaluated between 2011 and 2017. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) and immunofluoresc ...Daha fazlası
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve cerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.