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Süresiz Ambargo

Identification of medically important yeasts by sequence analysis of the internal transcribed spacer and D1/D2 region of the large ribosomal subunit

AYDIN, Merve | KUŞTİMUR, Semra | KALKANCI, Ayşe | DURAN, Tuğçe

Background: The prevalence of opportunistic yeast infections has increased in recent decades as the resultof an increasing immunocompromised patient population.Aims: To evaluate ribosomal RNA (rRNA) gene sequence to identify medically important yeast species, toinvestigate the performance of both the rRNA gene internal transcribed spacer (ITS) and D1/D2 region in identifying clinically relevant yeasts, and to compare these results with those of a standard phenotypicmethod.Methods: Both regions from 50 yeast strains, comprising 45 clinical isolates and 5 reference strains, wereamplified using P ...Daha fazlası

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The Effect of Hypnosis on Respiratory Function in Addicted to Cigarette Smoking

SUNAR, Füsun | FARZIN, Henareh Chareh

AIM: Most notably chronic obstructive pulmonary disease (COPD) and smoking brings about a variety of diseases contributing to lung cancer. Our aim is to investigate the effect of hypnosis on pulmonary functions in case smoker with spirometry. METHOD: Our research was done on a 53-year old patient with COPD who has been smoking a pack of cigarettes a day for 30 years and suffering from exertional dyspnea for last 5 years. Spirometry was applied on the male patient consulted for smoking cessation by taking advantage of hypnotherapy. Using fast hypnosis technique, the patient was put into trance. ...Daha fazlası

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Molecular characterization and subtyping of Blastocystis in urticarial patients in Turkey

AYDIN, Merve | YAZICI, Mustafa | DEMİRKAZIK, Mehtap | KOLTAŞ, İsmail Soner | ÇIKMAN, Aytekin | GÜLHAN, Barış | DURAN, Tuğçe | YILMAZ, Aysun | KARA, Murat

Objective: To investigate Blastocystis’ etiologic role and association with gastrointestinal symptomatology in acute and chronic urticaria patients and to identify Blastocystis subtypes responsible for urticaria. Methods: The study included urticaria patients and healthy individuals that presented to our polyclinic between June 2015 and May 2017. The participants were assigned into Group I (137 patients), subdivided into acute (72) and chronic urticaria patients (65), and Group II (129 control individuals). Blastocystis presence was investigated by native-Lugol examination, trichrome staining, ...Daha fazlası

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İnsan parechoviruslarının özellikleri, epidemiyolojisi ve klinik önemi

TOKAK, Semih | ÖZDEMİR, Mehmet

İnsan Parechoviruslar (Human Parechovirus; HPeV) tek iplikli, pozitif polariteli RNA viruslarıdır. Başlangıçta klinik ve morfolojik özelliklerine göre insan enterovirusları içerisinde Echovirus 22 ve 23 olarak tanımlansalar da, genom organizasyonu, yapı ve replikasyonlarında birkaç farklı özellikleriyle enteroviruslar ve diğer picornavirus gruplarından farklı oldukları gösterilmiştir. HPeV’ler genetik ve antijenik heterojenlik göstermekte ve birçok tipi dünyanın her yerinde bulunan insan popülasyonunda yaygın bir şekilde bulunmaktadır. HPeV1 en yaygın genotip olup sıklıkla gastrointestinal ve ...Daha fazlası

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The Effect of Hypnosis on Systolic Blood Pressure

SUNAR, Füsun | SOLAK GÖRMÜŞ, Zülfikare Işık

Hypnosis is frequently used in numerous fields of complementary medical treatments. Blood pressure is an important vital sign. The changes manifest itself with hypo/ hypertension. Hypertension is a common and important health problem in society. Our aim is to evaluate the effect of hypnosis on blood pressure in healthy volunteers and to make a preliminary study for treatment of hypertensive patients. Healthy twelve volunteers, six women and six men, aged between 18 - 65 years were included after getting ethical permits and consent. The room selected for hypnosis was quiet and room temperature ...Daha fazlası

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Age-dependent evaluation of long-term depression responses in hyperthyroid rats: Possible roles of oxidative intracellular redox status

TAN, Burak | BABUR, Ercan | KOŞAR, Bilal | VAROL, Salih | DURSUN, Nurcan | SÜER, Cem

Background According to the free radical theory, a gradual accumulation of the free radicals normally produced in the body underlies the changes associated with aging. Thyroid hormones (THs) are related to oxidative stress not only due to their stimulation of metabolism but also due to their effects on antioxidant mechanisms. Thyroid dysfunction increases with age; thus, changes in TH levels in elderly individuals could be a factor affecting the development of neurodegenerative diseases. However, the relationship is not always clear, based on current evidence regarding synaptic plasticity. Met ...Daha fazlası

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Absence of the mecC gene in methicillin-resistant Staphylococcusaureus isolated from various clinical samples: The first multi-centeredstudy in Turkey

ÇIKMAN, Aytekin | AYDIN, Merve | GÜLHAN, Barış | KARAKEÇİLİ, Faruk | KURTOĞLU, Muhammet Güzel | YÜKSEKKAYA, Şerife | PARLAK, Mehmet | GÜLTEPE, Sümbül Bilge | ÇOPUR ÇİÇEK, Ayşegül | BAYINDIR BİLMAN, Fulya | ÇİFTÇİ, İhsan Hakkı | KARA, Murat | ATMACA, Selahattin | ÖZEKİNCİ, Tuncer

tBackground: mecA is a predefined gene causing methicillin resistance in Staphylococcus aureus (S. aureus)isolates; however, it has been shown that some methicillin-resistant S. aureus (MRSA) strains do notcarry this gene. Recently, in isolates found to be MRSA-positive but mecA-negative, a new resistance gene called mecC, which is a homolog of mecA, has been reported. This study aimed to investigate the mecCand mecA genes in MRSA strains isolated from different geographic regions in Turkey.Methods: The sample of the study consisted of 494 MRSA strains isolated from seven geographical regionsi ...Daha fazlası

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Borrelia burgdorferi chemotaxis toward tick protein Salp12 contributes to acquisition

MURFIN, Kristen E. | KELINBARD, Ruby | AYDIN, Merve | SALAZAR, Samuel A. | FIKRIG, Erol

Lyme disease is a common tick-borne infection caused by the spirochete Borrelia burgdorferi sensu stricto (s.s.). B. burgdorferi s.s. may utilize chemotaxis, the directional migration towards or away from a chemical stimulus, for transmission, acquisition, and infection. However, the specific signals recognized by the spirochete for these events have not been defined. In this study, we identify an Ixodes scapularis salivary gland protein, Salp12, that is a chemoattractant for the spirochete. We demonstrate that Salp12 is expressed in the I. scapularis salivary glands and midgut and expression ...Daha fazlası

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Effect of 3’-4’-dihydroxyflavonol on lipid per oxidation inexperimental renal ischemia-reperfusion in rats

KOÇ, Aynur | ERGENE, Neyhan | BALTACI, Abdülkerim Kasım | MOĞULKOÇ, Rasim

This study aimed to examine the affects of 3’-4’-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental renal ischemia-reperfusion. The research was conducted on Wistar-albino type male rat. The experimental groups were formed as 1.Control; 2.Sham; 3.Ischemia; 4.Ischemia+reperfusion; 5.DiOHF+Ischemia; 6.Ischemia+ DiOHF + reperfusion. The highest tissue glutathione levels were found in groups 5 and 6. Groups 1 and 2, which were control and sham groups respectively, had the lowest tissue GSH values. Ischemia group was found to have the highest tissue malondialdehyde (MDA) level. Tissue ...Daha fazlası

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In vitro anti-candidal and anti-biofilm activity of new ethane sulfonyl hydrazone compound

ÖZTÜRK, Ali | AYDIN, Merve | ÖZDEMİR ÖZMEN, Ümmühan

Candida species cause cutaneous and systemic infections with a high mortality rate, especially in immunocompromised patients. However, the emergence of resistance to the most common antifungal drugs, also due to biofilm formation, there is an increasing need to design new and more effective antifungals with less toxic. Sulfonyl hydrazones are well-known for their pharmacological effects, such as antifungal and antibacterial potential and can act as an antinociceptive, antidepressant, antineoplastic activity. The aim of this study was to investigate the anti-candidal and anti-biofilm activity o ...Daha fazlası

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In vitro antifungal and antibiofilm activities of new butane sulfonyl hydrazone compound against medically important yeast

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | ÖZDEMİR ÖZMEN, Ümmühan

The prevalence of fungal infections has increased in the last two decades in parallel with the increasing number of immunosuppressed patients. The excessive use of antifungal agents is causing the accumulation of multi-resistance phenotypes in many fungal strains. Consequently, new alternative agents to conventional antifungal agents are urgently needed to prevent the emergence of fungal resistance. Sulfonyl hydrazone derived from sulfonamide, are well-known for their pharmacological effects, such as antifungal, antibacterial potential, and antineoplastic activity. This study aimed to investig ...Daha fazlası

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Examining The Antitumoral Effect of Cornelian Cherry (Cornus Mas) in Ehrlich Ascites Tumor-Induced Mice

YILMAZ, Seher | ALPA, Şerife | NİSARİ, Mehtap | ŞEKER KARATOPRAK, Gökçe | ÜLGER, Harun | ERTEKİN, Tolga

Introduction: Different doses of C. Mas concentrated syrup on ascitic tumors was investigated in the Ehrlich Ascites Tumor model (EAT). Material and Methods: A total of 46 Balb/C mice were used in our study, 6 of which were stock animals and the other were in ascitic tumor groups. EAT cells (1x106 EAT cells) were injected intraperitoneally into all of the mice. Mice in the treatment groups with ascitic tumors received 100 mg/kg and 200 mg/kg Cornus Mas extract intraperitoneally for 9 days. Results: Counts after the 3 and 24-hour incubations in the EAT cell line that the average number of the d ...Daha fazlası

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