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Bulunan: 7 Adet 0.001 sn
Konu Başlıkları : Breast Cancer ✕İlgili Araştırmacılar : Elif Gülbahçe Mutlu ... ✕
Koleksiyon [2]
İlgili Araştırmacılar [10]
Ambargo Durumu [1]
Tam Metin [1]
Yayın Türü [3]
Yazar/lar [10]
Atıf Dizini [3]
Konu Başlıkları [15]
Yayıncı [5]
Yayın Tarihi [4]
Yayın Dili [2]
dc.description.provenance [1]
Dr. Öğr. Üyesi Elif Gülbahçe MutluKTO KARATAY ÜNİVERSİTESİ/TIP FAKÜLTESİ/TEMEL TIP BİLİMLERİ BÖLÜMÜ/TIBBİ BİYOLOJİ ANABİLİM DALI/
Erişime Açık

The Cytotoxic Effects of Soybean (Glycine max L.) in Breast Cancer MCF-7 Cell Line In Vitro

KOYGUN, Gözde | ARSLAN, Emine | GÜLBAHÇE MUTLU, Elif

Aim of the study: Breast cancer is one of the most noticeable disease in women aged 20-59 years also it is expected to account for 30% of all new cancer diagnoses in women in 2016, Long-term use ofsoybean (Glycine max 1.) may prevent the progression of cancer. However, the molecular mechanism forthe functions of soybean remains unclear. So we decided to see how effective soybeans are on MCF-7Cell lines. Materials and Methods: Human breast cancer cell lines MCF-7 were treated with different concen-trations of methanol extract of soybean seeds. The growth rate was evaluated by XTT tests for 48 a ...Daha fazlası

Sunum 2018 2nd International UNIDOKAP Black Sea Symposium on Biodıversty 5 Görüntülenme
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Increased IL-6 Levels Inhibites by Zinc and Melatonin Support in Rats with Breast Cancer induced by DMBA

BALTACI, Saltuk Buğra | GÜLBAHÇE MUTLU, Elif | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The aim of the present study determines the effect of zinc and melatonin supplementation on IL-6 levels in female rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). Total 42 wistar female rats which was just weaned from milk equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+Zinc, Group 4 DMBA+Melatonin, Group 5 DMBA+Zinc+Melatonin. To induce breast cancer, the animals, except those in group 1, were administered 80 mg/kg of DMBA in colza oil (canola) through gavage. The groups which were supplemented with zinc and melatonin were introperitone ...Daha fazlası

Konferans Bildirisi 2018 Internatıonal Academic Research Congress (INES-2018) 8 Görüntülenme
Erişime Açık

The Effect of Zinc and Melatonin Supplementation on Lipid Peroxidation of Various Tissues of Rats with by DMBA-Induced Breast Cancer

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra

The purpose of this study was to investigate the effects of zinc and melatonin administration on lipid peroxidation in various tissues in DMBA-induced breast cancer in female rats. A total of 42 recently weaned Wistar rats were divided into 5 groups in the study: Group 1 (Control), Group 2 (DMBA Control), Group 3 (DMBA+Zinc), Group 4 (DMBA+Melatonin), Group 5 (DMBA+Melatonin, and Zinc). MDA (malondialdehyde) and GSH (glutathione) levels were determined via the spectrophotometric method in the lung, liver, spleen, pancreas, and kidney tissue samples taken from experimental animals. The highest ...Daha fazlası

Makale 2021 Biointerface Research 1 Görüntülenme
Erişime Açık

Prevention of Increased Brain Cortex Damage by Zinc and Melatonin in Rats with Breast Cancer induced by DMBA

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

ABSTRACT: The aim of the present was study determine the effects of zinc and melatonin on brain tissue (cortex) lipid peroxidation in rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). Total 42 female wistar rats which was just weaned from milk equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+ Zinc, Group 4 DMBA + Melatonin, Group 5 DMBA + Zinc +Melatonin. To induce breast cancer 80 mg/kg DMBA was given by gavage in colza oil (except group 1). Zinc and melatonin were supplemented as 5 mg/kg/day for 4 weeks. Brain tissue samples (cortex) wer ...Daha fazlası

Konferans Bildirisi 2018 Internatıonal Academic Research Congress (INES-2018) 5 Görüntülenme
Erişime Açık

Zinc And Melatonin Supplementation Ameliorates Brain Cortex Tissue Damage in Dmba-Induced Breast Cancer İn Rats

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra

BACKGROUND: This study aims to investigate the effects of zinc and melatonin supplementation on lipid peroxidation in the brain cortex in DMBA-induced breast cancer in female rats. METHODS: A total of 42 recently weaned Wistar rats were divided into 5 groups as follows: Control (Group 1), DMBA Control (Group 2), DMBA+Zinc (Group 3), DMBA+Melatonin (Group 4), DMBA+Melatonin & Zinc (Group 5). At the end of the study, all animals were sacrifi ced by decapitation and Malondialdehyde (MDA) and glutathione (GSH) levels in brain cortex tissue samples were determined via spectrophotometric methods. RE ...Daha fazlası

Makale 2020 Bratisl Med J 3 Görüntülenme
Erişime Açık

The Effect of Support of Zinc and Melatonin on Lipid peroxidation of Various Tissues in Rats with Breast cancer induced by DMBA

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The aim of the present was study determine the effect of zinc and melatonin supplementation on lipid peroxidation of various tissues in female rats with breast cancer induced by DMBA (7,12- Dimethylbenz[a]anthracene). Total 42 Wistar albino female rats were equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+Zinc, Group 4 DMBA + Melatonin, Group 5 DMBA+Zinc+Melatonin. Lung, liver, spleen, pancreas and kidney tissue of rats were examined for MDA and GSH by spectrophotometric. The highest lung, liver, spleen, pancreas and kidney MDA levels were determined in group 2 ( ...Daha fazlası

Konferans Bildirisi 2018 Internatıonal Academic Research Congress (INES-2018) 7 Görüntülenme
Erişime Açık

Determination Of Cytoxic Effects Of Oxytocin And Atosiban Mcf-7 Cell Line

ERBAYRAM, Fatma Zehra | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | TÜRKOĞLU, Fatma Nur | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, a major cause of cancer-related deaths, is an important health problem due to its inadequate response to treatment and complex etiology. Oxytocin (OT) is a peptide mammalian hormone consisting of nine amino acids. Today, cellular studies of oxytocin have gained importance. Oxytocin has been observed to inhibit cell proliferation in cancer. The biggest advantage of oxytocin therapies is that they provide the organism with cell production on its own and have no side effects. Studies have shown that OT is a factor that stimulates cell proliferation in lung, ...Daha fazlası

Konferans Bildirisi 2023 Selçuk Üniversitesi 0 Görüntülenme
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