The 21st Century Skills of Prep Students

TAYTAK ÜN, Gülberk

This descriptive study aims to investigate prep students’ perception of 21st Century Skills that have gained a great significance recently as a result of major developments in technology which has an impact on every field of life. These skills also required some innovations in the field of education, and Foreign Language education, which is based on communication, also includes some innovations as a natural consequence of this situation. While students of bachelor’s degree were expected to have only sufficient academic knowledge in the past, nowadays it’s a must for a person to have some quali ...Daha fazlası

In Vitro Activity of Coenzymeq10 Loaded Mesoporous Silica Nanoparticles Against Mcf-7 Cells

GÜLBAHÇE MUTLU, Elif | ŞEFLEK, Hatice Nur | ALPA, Şerife | ERTUŞ, Emre Burak | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur

Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası

Determination of Cytoxic Effects of Diazepam and Flumazenil in MCF-7 Cell Line

TÜRKOĞLU, Fatma Nur | ALPA, Şerife | GÜLBAHÇE MUTLU, Elif | ERBAYRAM, Fatma Zehra | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, the second most common cause of cancer death, is a global public health problem due to its poor response to treatment and complex aetiology. The MCF-7 cell line is widely used in laboratories around the world for in vitro studies to address this problem. Diazepam is one of the most successful anaesthetics since the beginning of the psychopharmacological revolution. It belongs to a class of benzodiazepines that is often preferred in anaesthesia. Flumazenil is an imidazobenzodiazepine and was the first benzodiazepine antagonist to enter clinical use. The e ...Daha fazlası

Determination Of Cytoxic Effects Of Oxytocin And Atosiban Mcf-7 Cell Line

ERBAYRAM, Fatma Zehra | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | TÜRKOĞLU, Fatma Nur | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, a major cause of cancer-related deaths, is an important health problem due to its inadequate response to treatment and complex etiology. Oxytocin (OT) is a peptide mammalian hormone consisting of nine amino acids. Today, cellular studies of oxytocin have gained importance. Oxytocin has been observed to inhibit cell proliferation in cancer. The biggest advantage of oxytocin therapies is that they provide the organism with cell production on its own and have no side effects. Studies have shown that OT is a factor that stimulates cell proliferation in lung, ...Daha fazlası

Determination of The Cytotoxic Effect of Propylthiouracil Loaded Mesoporous Silica on Mcf-7 Cell Line

GÜLBAHÇE MUTLU, Elif | ŞEFLEK, Hatice Nur | ALPA, Şerife | ERTUŞ, Emre Burak | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur

Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası

Semen Microbiome Dysbiosis In Male Infertility

ŞEFLEK, Hatice Nur | ERBAYRAM, Fatma Zehra | TOKAK, Semik

Infertility is a major health problem and is increasing worldwide. The shift in the age at which both partners have their first child to older ages and lifestyle changes have contributed to the increase in the incidence of infertility. 50% of infertility in couples is due to male infertility. In vitro studies show that bacteria can negatively affect sperm function. Bacteria; has been shown to play an important role in many mechanisms that affect sperm function, including agglutination of motile sperm, induction of apoptosis, production of immobilization factors, and disruption of acrosome resp ...Daha fazlası

The Effect Of Coenzyme Q10 Administration On The Expression Of Some Genes In Rats With Hypothroidia

ŞEFLEK, Hatice Nur | GÜLBAHÇE MUTLU, Elif | CÜCE, Gökhan | KALKAN, Serpil

Introduction: Hypothyroidism is an endocrine disorder that occurs mainly due to the insufficiency of thyroid hormones in the body or the inability of these hormones to affect target tissues. As a result of the insufficiency of thyroid hormones, the systems are affected and accordingly, the health status of individuals is adversely affected. Coenzyme Q10 is a lipophilic antioxidant that plays a role in membrane stability, energy conversion and ATP production. The aim of this study was to determine the effect of Coenzyme Q10 on GDNF, PLZF, SOX3 and THY1 gene expression levels in rats with hypoth ...Daha fazlası

Sustainable supplier selection during micro crises in the manufacturing indutry: An application for the automotive spare parts indutry

ÇİZMECİOĞLU, Sinan | ÇALIK, Ahmet

Effect of New Sulfonyl Hydrazone Compounds Against Candida Biofilms

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | DURAN, Tuğçe | ÖZDEMİR ÖZMEN, Ümmühan | ŞUMLU, Esra

Objectives: Candidiasis is the most frequently encountered fungal infection, with ranges from mild superficial infections to disseminated candidiasis. Most manifestations of Candidiasis are associated with biofilm formation. Candida biofilms contributes to therapeutic failure due to resistance to antimicrobial agents and causes an increase in mortality rates. For these reasons, finding new drugs and antimicrobial agents are urgently needed. Sulfonyl hydrazones derived from sulfonamide, are well-known for its pharmacological effects, such as antifungal, antibacterial potential activity. This st ...Daha fazlası

Expression of Sap Genes 1-10 and Biofilm Formation in Candida Spp. Comparison of Healthcare Associated infectıon isolates from Bloodstream with Isolates from Other Sources

NSANGOU, Ahmed Moustapha | SAMADZADE, Rugiyya | DURAN, Tuğçe | MAÇİN, Salih | AYDIN TERZİOĞLU, Merve | FINDIK, Duygu

Candida species are yeast fungi that are common in nature and can cause both superficial and deep infections. According to recent data, Candida species are considered to be the main causative agents of healthcare-associated infections. In this study, it was aimed to determine Candida species, Sap genes and biofilm formation isolated from blood cultures, which are health care-associated infectious agents, and to evaluate them together with antifungal susceptibility tests. Candida spp. were identified by the Vitek 2 Compact method and then the results were verified by multiplex PCR and DNA seque ...Daha fazlası

Work Life In Turkey In The Context Of Social Risk And Uncertainty

EKİZ ATAŞER, İlknur

This research focuses on social, political and economic uncertainties and risks in work life. Based on a field research in industrial companies in Konya/Turkey, I focus on how patterns of work develop on the basis of capital, labor and employment. The central issue in this attempt is to ascertain how industrial workers are influenced by social, political and economic uncertainties and risks. In other words, this study explores how these uncertainties and risks, real or imagined, are reflected in the work life of individuals and shape their agencies in work life. Based on quantitative and quali ...Daha fazlası

Investigation of the Effect of Processor Type on Daily Implant Use Time in Cochlear Implant Users

EŞDOĞAN, Ayşegül | AYKUL YAĞCIOĞLU, Ayşenur | KARAKÜLÜK, N.İrem | ÖZBAL BATUK, Merve

Introduction: In individuals with cochlear implants (CI), continuous wear of the hearing devices is crucial for maintaining auditory input and supporting auditory development. It is recommended that cochlear implant processors be used throughout waking hours. Modern cochlear implant systems provide clinicians with data on the usage of sound processors by CI users through a process known as "data logging." This data logging enables the automatic and objective measurement of CI usage based on average daily usage hours. Previous studies examining data records of patients with CIs have revealed si ...Daha fazlası