Internal acoustic opening: Different osseous landmarks and their clinical implications

AKIN SAYGIN, Duygu | TÜRKOĞLU, Fatma Nur | AYDIN KABAKÇI, Anıl Didem | ALPA, Şerife

ABSTRACT: Internal acoustic opening is a space that opens to facies posterior of the petrous piece of temporal bone that goes inside facial nerve, vestibulocochlear nerve, intermedial nevre and labyrinthine artery. The purpose of this study is the assessment of internal acoustic opening from a morphometric perspective, determination of the shape of the hole and determination of the distance to some important anatomic formations. This study is conducted on 166 temporal bones with unknown sex formation which are part of the skull collection in NEU and KTO Karatay University, Anatomy Department. ...Daha fazlası

Morphometric Evaluation of Rarely Seen Supratrochlear Foramen and Supracondylar Process in the Humerus in Turkish Population

AKIN SAYGIN, Duygu | TÜRKOĞLU, Fatma Nur | TOKPINAR, Adem | UÇAR, Sümeyye | YILMAZ, Seher | AYDIN KABAKÇI, Anıl Didem | ALPA, Şerife

Abstract Background: Sometimes seen distal to humerus foramen supratrochleare and supracondylar process are rare variations. Supracondylar process is a variations observed on the distal side of humerus. The supracondylar process is a variant located 1/3 distal side of the humerus. The supratrochlear foramen may appear between the coronoid fossa and olecranon fossa. Since the foramen may appear in a semi-transparent form, it may be misdiagnosed as an osteolytic lesion. The aim of the present study was to identify the prevalence and morphology of supratrochlear foramen and the supracondylar proc ...Daha fazlası

A morphometric and morphological analysis of superior border of dry scapulae

AKIN SAYGIN, Duygu | TÜRKOĞLU, Fatma Nur | AYDIN KABAKÇI, Anıl Didem | ALPA, Şerife | YILMAZ, Mehmet Tuğrul

Aim: The recognition of the scapula anatomy and visible variations is important in surgical treatments and arthroscopic procedures in case of any diseases of the shoulder. The morphological and morphometric characteristics of the scapular notch on the superior margin are very important. Because compression of the suprascapular nerve extending inside the scapular notch causes entrapment neuropathy. Therefore, the present study was planned in order to contribute to us as well as practitioners about morphometric and morphological characteristics of the superior margin of the scapula. Materials an ...Daha fazlası

Examining The Antitumoral Effect of Cornelian Cherry (Cornus Mas) in Ehrlich Ascites Tumor-Induced Mice

YILMAZ, Seher | ALPA, Şerife | NİSARİ, Mehtap | ŞEKER KARATOPRAK, Gökçe | ÜLGER, Harun | ERTEKİN, Tolga

Introduction: Different doses of C. Mas concentrated syrup on ascitic tumors was investigated in the Ehrlich Ascites Tumor model (EAT). Material and Methods: A total of 46 Balb/C mice were used in our study, 6 of which were stock animals and the other were in ascitic tumor groups. EAT cells (1x106 EAT cells) were injected intraperitoneally into all of the mice. Mice in the treatment groups with ascitic tumors received 100 mg/kg and 200 mg/kg Cornus Mas extract intraperitoneally for 9 days. Results: Counts after the 3 and 24-hour incubations in the EAT cell line that the average number of the d ...Daha fazlası

Adım Adım Anatomi

BABACAN, SERDAR | ÖZBAĞ, Davut | GÜLER, Mehmet Akif | ÖZTEKİN, Hüseyin Cahit | YILDIZ, Ziya | KELEŞ, Ali | GÜNGÖRER, Şule | ALPA, Şerife | ÖĞÜT, Eren | AYDIN KABAKÇI, Anıl Didem | TÜRKOĞLU, Fatma Nur | YILMAZ, Seher | TOKPINAR, Adem | ÖZDEMİR, Fikri | CANDAN, Büşra | ÇINAROĞLU, Selim | GÖLPINAR, Murat | ÖZKAN, Mazhar | KESKİNÖZ, Elif Nedret | ŞENOL, Deniz

Anatomi, tüm sağlık alanlarının temel taşı niteliğindedir. Tüm sağlık alanı ile ilgili eğitimlerde anatomi iyi öğretilmesi ve öğrenilmesi gereken bir derstir. Ülkemizde Tıp Fakültelerinden, Sağlık Bilimleri Fakülteleri ile Sağlık Meslek Yükseokulları’na kadar birçok okulda ders olarak okutulmaktadır. Anatomi dersi, ancak ve ancak görsel içeriğin zengin olduğu anlatımlarla olduğunda işlevselliği yüksektir. Bu amaçla görsel açıdan zengin resimlerle desteklenmiş, sistematik olarak adım adım Anatomi’yi öğretmeyi hedefleyen bu kitap hazırlanmıştır. Bu kitap, Tıp Fakülteleri, Diş Hekimliği Fakültele ...Daha fazlası

Investigating the anti-tumoral effect of curcumin on the mice inwhich Ehrlich ascites and solid tumor is created

YILMAZ, Seher | ÜLGER, Harun | ERTEKİN, Tolga | YAY, Arzu Hanım | NİSARİ, Mehtap | ALPA, Şerife | ACER, Niyazi

Volume estimation of the subcortical structuresin Parkinson’s disease using magnetic resonanceimaging: A methodological study

ERTEKİN, Tolga | ACER, Niyazi | İÇER, Semra | ALPA, Şerife

In Vitro Activity of Coenzymeq10 Loaded Mesoporous Silica Nanoparticles Against Mcf-7 Cells

GÜLBAHÇE MUTLU, Elif | ŞEFLEK, Hatice Nur | ALPA, Şerife | ERTUŞ, Emre Burak | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur

Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası

Determination of Cytoxic Effects of Diazepam and Flumazenil in MCF-7 Cell Line

TÜRKOĞLU, Fatma Nur | ALPA, Şerife | GÜLBAHÇE MUTLU, Elif | ERBAYRAM, Fatma Zehra | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, the second most common cause of cancer death, is a global public health problem due to its poor response to treatment and complex aetiology. The MCF-7 cell line is widely used in laboratories around the world for in vitro studies to address this problem. Diazepam is one of the most successful anaesthetics since the beginning of the psychopharmacological revolution. It belongs to a class of benzodiazepines that is often preferred in anaesthesia. Flumazenil is an imidazobenzodiazepine and was the first benzodiazepine antagonist to enter clinical use. The e ...Daha fazlası

Determination Of Cytoxic Effects Of Oxytocin And Atosiban Mcf-7 Cell Line

ERBAYRAM, Fatma Zehra | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | TÜRKOĞLU, Fatma Nur | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, a major cause of cancer-related deaths, is an important health problem due to its inadequate response to treatment and complex etiology. Oxytocin (OT) is a peptide mammalian hormone consisting of nine amino acids. Today, cellular studies of oxytocin have gained importance. Oxytocin has been observed to inhibit cell proliferation in cancer. The biggest advantage of oxytocin therapies is that they provide the organism with cell production on its own and have no side effects. Studies have shown that OT is a factor that stimulates cell proliferation in lung, ...Daha fazlası

Determination of The Cytotoxic Effect of Propylthiouracil Loaded Mesoporous Silica on Mcf-7 Cell Line

GÜLBAHÇE MUTLU, Elif | ŞEFLEK, Hatice Nur | ALPA, Şerife | ERTUŞ, Emre Burak | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur

Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası

Determination of Antioxidant and Anticancer Activities of C. Sativa Leaf Extracts on MCF7 Human Breast Cancer Cell Line

BEYAZYÜZ, Fadime | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur | KULAÇ, Şemsettin

Aim: In this study, it was aimed to determine the total phenolic content, flavonoid content, and antioxidant activity of Castanea sativa Mill. (chestnut) leaf extract and their anti-proliferative effect on MCF 7 cell line. Materials and Methods: It determined antioxidant capacities by using DPPH assay, total phenolic content by using Folin-Ciocaltaeu method and Total flavonoid content by aluminum chloride colorimetric method in the ethanolic extracts of Chesnut leaf. In addition, the anti-proliferative effect of chestnut leaf extract was determined by XTT method in MCF7 breast cell line. The l ...Daha fazlası