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Mammary cancer, which is the second most common cause of cancer deaths, is one of the problems of global public health. It is argued that anti estrogenic agents such as melatonin will lead to a new aspect in treatment of breast cancer. In addition, zinc, which plays a crucial role in the etiology of cancer, is vital for many cellular processes, and an important trace mineral. Trace elements are regarded as multiple anti-cancer agents that regulate various biological mechanisms. METHODS: In this study, it was aimed to investigate the effects of melatonin and zinc application on lipid peroxidati ...Daha fazlası
Introduction and Objectives: The aim of this study is to investigate the effect of the chronic running exercise in diabetic rats on lipid peroxidation in hippocampus tissue. The study was carried out in Experimental Medicine Research and Application Center of Selçuk University on adult male Wistar rats that were obtained from the same center. The study protocol was approved by the Ethics Committee of Experimental Animals of Experimental Medicine Research and Application Center of Selcuk University. Methods: A total of 40 rats were equally divided into 4 groups: Group 1, Control, Group 2, Exerc ...Daha fazlası
Amaç: Bu çalışmanın amacı dişi sıçanlarda DMBA ile oluşturulmuş meme kanserinde çinko ile melatonin uygulamasının uterus dokusundaki lipit peroksidasyonu üzerine olan etkilerinin araştırılmasıdır. Gereç ve Yöntem: Wistar cinsi sütten yeni kesilmiş toplam 42 adet dişi sıçan kullanılan araştırmada hayvanlar 5 gruba ayrıldı: Grup 1 Kontrol, Grup 2 DMBA Kontrol, Grup 3 DMBA+Çinko, Grup 4 DMBA+Melatonin, Grup 5 DMBA+Melatonin ve Çinko. Grup 1 dışındaki hayvanlara meme kanseri oluşturmak için kolza yağı (kanola) içinde 80 mg/kg dozunda DMBA gavaj yoluyla verildi. Çinko ve melatonin uygulanan gruplar ...Daha fazlası
The purpose of this study was to investigate the effects of zinc and melatonin administration on lipid peroxidation in various tissues in DMBA-induced breast cancer in female rats. A total of 42 recently weaned Wistar rats were divided into 5 groups in the study: Group 1 (Control), Group 2 (DMBA Control), Group 3 (DMBA+Zinc), Group 4 (DMBA+Melatonin), Group 5 (DMBA+Melatonin, and Zinc). MDA (malondialdehyde) and GSH (glutathione) levels were determined via the spectrophotometric method in the lung, liver, spleen, pancreas, and kidney tissue samples taken from experimental animals. The highest ...Daha fazlası
BACKGROUND: This study aims to investigate the effects of zinc and melatonin supplementation on lipid peroxidation in the brain cortex in DMBA-induced breast cancer in female rats. METHODS: A total of 42 recently weaned Wistar rats were divided into 5 groups as follows: Control (Group 1), DMBA Control (Group 2), DMBA+Zinc (Group 3), DMBA+Melatonin (Group 4), DMBA+Melatonin & Zinc (Group 5). At the end of the study, all animals were sacrifi ced by decapitation and Malondialdehyde (MDA) and glutathione (GSH) levels in brain cortex tissue samples were determined via spectrophotometric methods. RE ...Daha fazlası
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