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Bulunan: 10 Adet 0.001 sn
Ambargo Durumu [1]
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Erişime Açık

In vitro anti-candidal and anti-biofilm activity of new ethane sulfonyl hydrazone compound

ÖZTÜRK, Ali | AYDIN, Merve | ÖZDEMİR ÖZMEN, Ümmühan

Candida species cause cutaneous and systemic infections with a high mortality rate, especially in immunocompromised patients. However, the emergence of resistance to the most common antifungal drugs, also due to biofilm formation, there is an increasing need to design new and more effective antifungals with less toxic. Sulfonyl hydrazones are well-known for their pharmacological effects, such as antifungal and antibacterial potential and can act as an antinociceptive, antidepressant, antineoplastic activity. The aim of this study was to investigate the anti-candidal and anti-biofilm activity o ...Daha fazlası

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In vitro antifungal and antibiofilm activities of new butane sulfonyl hydrazone compound against medically important yeast

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | ÖZDEMİR ÖZMEN, Ümmühan

The prevalence of fungal infections has increased in the last two decades in parallel with the increasing number of immunosuppressed patients. The excessive use of antifungal agents is causing the accumulation of multi-resistance phenotypes in many fungal strains. Consequently, new alternative agents to conventional antifungal agents are urgently needed to prevent the emergence of fungal resistance. Sulfonyl hydrazone derived from sulfonamide, are well-known for their pharmacological effects, such as antifungal, antibacterial potential, and antineoplastic activity. This study aimed to investig ...Daha fazlası

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Asymptomatic dermatophyte scalp carriage in school children in Erzincan, Turkey

AYDIN, Merve | GÜLHAN, Barış | GÜMRAL, Ramazan | İLKİT, Macit | ÖZTÜRK, Ali

Background: This study aimed to investigate the prevalence of symptomatic tinea capitis infections of the scalp and its asymptomatic carriage in students attending primary schools in Erzincan, Turkey. Materials and Methods: Eighteen primary schools were visited; 1 located in the central district and 17 located in other districts of the Erzincan province. From 2015 November to 2016 April, scalp scrapings were obtained from a total of 1879 students aged 6 to 13 years (mean age: 9.37±1.69) 924 (49.2%) male and 955 (50.8%) female using sterile hairbrushes, and assessed for tinea capitis and asympt ...Daha fazlası

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Early autism diagnosis of children with machine learning algorithms

BÜYÜOFLAZ, Fatiha Nur | ÖZTÜRK, Ali

Autism Spectrum Disorder (ASD) is a neuro-developmental disorder that has become one of the major health problems, and early diagnosis has a great deal of important in terms of controlling the disease. The increase in the number of autoimmune influenza and ASD cases in the world reveals an urgent need to develop easily applied and effective screening methods In this study, performance comparisons were made using three different classification methods, Naive Bayes, IBk (k-nearest neighbors), RBFN (radial basis function network), and Random Forest, on UCI 2017 Autistic Spectrum Disorder Screenin ...Daha fazlası

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Antifungal and anti-biofilm activity of new propane Sulfonyl Hydrazone Against Candida Isolates

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | ÖZDEMİR ÖZMEN, Ummuhan

Candidiasis is the most frequently encountered fungal disease that ranges from mild mucosal infections to serious candidaemia and disseminated candidiasis. There are only limited classes of antifungal agents available for physicians to combat Candida infections. In addition, biofilm cells display phenotypic traits that resulting in enhanced resistance to antifungal drugs. Therefore, the limited option to combat fungal threat has raised the interest in seeking alternative antifungal compounds. The aim of this study was to investigate the antifungal and anti-biofilm activity of the new Sulfonyl ...Daha fazlası

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Neuro-fuzzy Classification of Transcranial Doppler Signals with Chaotic Meaures and Spectral Parameters

ÖZTÜRK, Ali | ARSLAN, Ahmet

Transcranial Doppler (TCD) is a non-invasive diagnosis method which is used in diagnosis of various brain diseases by measuring the blood flow velocities in brain arteries. In this study, chaos analysis of the TCD signals recorded from the middle arteries of the temporal region of brain of the 82 patients and 23 healthy people was investigated. Among 82 patients, 20 of them had cerebral aneurism, 10 had brain hemorrhage, 22 had cerebral oedema and the remaining 30 had brain tumor. Maximum Lyapunov exponent which is the strongest quantitative indicator of chaos was found to be positive for all ...Daha fazlası

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Comparison of machine learning algorithms on different datasets

UYSAL, Elif | ÖZTÜRK, Ali

Machine learning algorithms are methods used to classify data. Aim of this study is comparison of machine learning algorithms on different datasets. For this study, 9 different machine learning algorithms with 10 fold cross validation method in WEKA is classified on 3 different datasets. As a result of classification, machine learning algorithm which has high accuracy rate is different for 3 datasets. Multilayer Perceptron algorithm for Car Evaluation dataset, Random Forest algorithm for Image Segmentation dataset and Simple Logistic algorithm for User Knowledge Modeling dataset were obtained. ...Daha fazlası

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Short term prediction of aluminium strip thickness via Support Vector Machines

ÖZTÜRK, Ali | ŞEHERLİ, Rıfat

The fundamental principle of cold rolling process is the tension produced by the coiling and uncoiling motors of the rolling machine. If the tension is not properly regulated, the strip thickness will not be homogenous over the surface and even ruptures may occur. Therefore, short-term prediction of the aluminium strip thickness is important to control the tension. In this study, nonlinear time series analysis methods were applied to the recorded thickness data in order to obtain the embedding vectors with appropriate embedding dimension and time delay. For various prediction horizons, the emb ...Daha fazlası

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Effect of New Sulfonyl Hydrazone Compounds Against Candida Biofilms

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | DURAN, Tuğçe | ÖZDEMİR ÖZMEN, Ümmühan | ŞUMLU, Esra

Objectives: Candidiasis is the most frequently encountered fungal infection, with ranges from mild superficial infections to disseminated candidiasis. Most manifestations of Candidiasis are associated with biofilm formation. Candida biofilms contributes to therapeutic failure due to resistance to antimicrobial agents and causes an increase in mortality rates. For these reasons, finding new drugs and antimicrobial agents are urgently needed. Sulfonyl hydrazones derived from sulfonamide, are well-known for its pharmacological effects, such as antifungal, antibacterial potential activity. This st ...Daha fazlası

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Chaos analysis of Transcranial Doppler signals for feature extraction

ÖZTÜRK, Ali

In this study, chaos theory tools were used for feature extraction from Transcranial Doppler (TCD) signals. The surrogates data sets of the TCD signals which were used for the nonlinearity analysis were extracted as the first feature set. The nonlinear cross prediction errors which were used for the stationary analysis were also extracted for the TCD signals as another feature set. The chaotic invariant features like correlation dimension, maximum Lyapunov exponent, recurrence quantification measures etc. give quantitative values of complexity of the TCD signals. The correlation dimension and ...Daha fazlası

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