Folic-Acid-Modified Conducting Polymer: Electrochemical Detection of the Cell Attachment.

AZAK, Hacer | BARLAS, Fırat Barış | YILDIZ, Hüseyin Bekir | GÜLEÇ, Kadri | DEMİR, Bilal | ODACI DEMİRKOL, Dilek | TİMUR, Suna

Here, postfunctionalization and bioapplication of a π-conjugated polymer named 4-[4H-dithieno(3,2-b:2',3'-d)pyrrol-4-yl]aniline (DTP-aryl-NH2 ) are reported, which is successfully synthesized via electropolymerization onto the glassy carbon electrode. Folic acid (FA) is used to modify the amino functional polymer via N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide chemistry for the further steps. The selective adhesion of folate receptor positive cells on the surface is followed by the electrochemical methods. Cyclic voltammetry and electrochemical impedance s ...Daha fazlası