Zinc Ameliorates Nogo-A Receptor and Osteocalcin Gene Expression in Memory-Sensitive Rat Hippocampus Impaired by Intracerebroventricular Injection of Streptozotocin.

GÜMÜŞ, Haluk | BALTACI, Saltuk Buğra | ÜNAL, Ömer | GÜLBAHÇE-MUTLU Elif | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

Metabolic dysfunction is a critical step in the etiopathogenesis of Alzheimer's disease. In this progressive neurological disorder, impaired zinc homeostasis has a key role that needs to be clarified. The aim of this study was to investigate the effect of zinc deficiency and administration on hippocampal Nogo-A receptor and osteocalcin gene expression in rats injected with intracerebroventricular streptozotocin (icv-STZ). Forty male Wistar rats were divided into 5 groups in equal numbers: Sham 1 group received icv artificial cerebrospinal fluid (aCSF); Sham 2 group received icv a CSF and i.p. ...Daha fazlası

Makale 2023 0 Görüntülenme

Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats.

GÜMÜŞ, Meltem | GÜLBAHÇE-MUTLU, Elif | ÜNAL, Ömer | BALTACI, Saltuk Buğra | ÜNLÜKAL, Nejat | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The aim of this study was to investigate how zinc deficiency and supplementation affect liver markers including autotaxin, kallistatin, endocan, and zinc carrier proteins ZIP14 and ZnT9 in rats exposed to maternal zinc deficiency. Additionally, the study aimed to assess liver tissue damage through histological examination. A total of forty male pups were included in the research, with thirty originating from mothers who were given a zinc-deficient diet (Groups 1, 2, and 3), and the remaining ten born to mothers fed a standard diet (Group 4). Subsequently, Group 1 was subjected to a zinc-defici ...Daha fazlası

Diğer 2023 0 Görüntülenme

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Zinc Ameliorates Nogo-A Receptor and Osteocalcin Gene Expression in Memory-Sensitive Rat Hippocampus Impaired by Intracerebroventricular Injection of Streptozotocin.

GÜMÜŞ, Haluk | BALTACI, Saltuk Buğra | ÜNAL, Ömer | GÜLBAHÇE-MUTLU Elif | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats.

GÜMÜŞ, Meltem | GÜLBAHÇE-MUTLU, Elif | ÜNAL, Ömer | BALTACI, Saltuk Buğra | ÜNLÜKAL, Nejat | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım