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dc.contributor.authorE. Murfin, Kristen
dc.contributor.authorKleinbard, Ruby
dc.contributor.authorAydin, Merve
dc.contributor.authorA. Salazar, Samuel
dc.contributor.authorFikrig, Erol
dc.date.accessioned2020-01-17T08:41:57Z
dc.date.available2020-01-17T08:41:57Z
dc.date.issued2019-08
dc.identifier.issn1877-959X
dc.identifier.urihttp://hdl.handle.net/20.500.12498/1639
dc.description.abstractLyme disease is a common tick-borne infection caused by the spirochete Borrelia burgdorferi sensu stricto (s.s.). B. burgdorferi s.s. may utilize chemotaxis, the directional migration towards or away from a chemical stimulus, for transmission, acquisition, and infection. However, the specific signals recognized by the spirochete for these events have not been defined. In this study, we identify an Ixodes scapularis salivary gland protein, Salp12, that is a chemoattractant for the spirochete. We demonstrate that Salp12 is expressed in the I. scapularis salivary glands and midgut and expression is not impacted by B. burgdorferi s.s. infection. Knockdown of Salp12 in the salivary glands or passive immunization against Salp12 reduces acquisition of the spirochete by ticks but acquisition is not completely prevented. Knockdown does not impact transmission of B. burgdorferi s.s. This work suggests a new role for chemotaxis in acquisition of the spirochete and suggests that recognition of Salp12 contributes to this phenomenon.en_US
dc.description.sponsorshipThis work was supported in part by NIH grants AI1260003 and AI138949 and gifts from the John Monsky and Jennifer Weis Monsky Lyme Disease Research Fund and from the Cohen Foundation.en_US
dc.language.isoen_USen_US
dc.publisherTicks and Tick-borne Diseaseen_US
dc.subjectSGEen_US
dc.subjectSalivary gland extracten_US
dc.subjectSalp12en_US
dc.subjectIxodes scapularis salivary gland protein of 12 kDaen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleBorrelia burgdorferi chemotaxis toward tick protein Salp12 contributes to acquisitionen_US
dc.typeArticleen_US


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