Relationship between generalized epileptic seizure and neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and neutrophil mediated inflammation
Gunes, Muzaffer and Buyukgol, Huseyin
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Abstract
Aim: There is a close relationship between systemic inflammation and
epileptic seizure. Recently, neutrophil/lymphocyte ratio (NLR) and
platelet/lymphocyte ratio (PLR) have been defined as significant
inflammation biomarkers. In the present study, it was aimed to determine
levels of NLR, PLR, and mean platelet volume (MPV) during generalized
tonic clonic epileptic seizures, and to investigate their relationships
with epileptic seizures. Methods: The present study was conducted on 72
patieents with epilepsy who applied with primary and secondary
generalized tonic clonic epileptic seizures according to classification
of the International League Against Epilepsy (ILAE), and 72 healthy
individuals as the control group. Neutrophil and lymphocyte counts, NLR,
PLR, and MPV values of patients were evaluated both in acute (in the
first hour of epileptic seizure) and subacute (in hour 72 of epileptic
seizure) phases by biochemical analysis. Results: Statistically
significant differences were determined in laboratory values of white
blood cell (WBC) (p < 0.001), neutrophil (p < 0.001), lymphocyte (p <
0.001), NLR (p < 0.001), MPV (p < 0.05), platelet (p < 0.001),
C-reactive protein (CRP) (p < 0.05) in acute phase; and in lymphocyte (p
< 0.05), NLR (p < 0.05), platelet (p < 0.001), and CRP (p < 0.001) in
subacute phase between patients and healthy controls. Statistically
significant differences were determined in laboratory values of WBC (p <
0.001), neutrophil (p < 0.001), lymphocyte (p < 0.05), NLR (p < 0.001),
CRP (p < 0.001), and PLR (p < 0.05) in patient group between acute and
subacute phases. In patient group, mean lymphocyte count was determined
lower in acute phase than subacute phase (p < 0.05). Conclusion: The
most striking finding of the present study is determination of 1 unit
increase in NLR results in 1.95 folds increase in epileptic seizure risk
in binary logistic regression analysis. Additionally, it indicates that
epileptic seizure is correlated with NLR, PLR, and neutrophil mediated
inflammation. To the best of authors knowledge, this is the first report
indicating that there is a relationship between epileptic seizure and
PLR, neutrophil mediated inflammation, and that 1 unit increase in NLR
increases epileptic seizure risk by 1.95 folds.... Show more Show less