Management of extravasation of oxaliplatin by mimicking its biotransformation
Bahadori, F. and Demiray, M.
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Abstract
Although oxaliplatin (Oxali) plays a key role in the treatment of many
types of cancer and has been reported to be an irritant, there is no
specific and effective method for its extravasation and failure in Oxali
extravasation management results in the need for plastic surgery. In the
body, Oxali bio-transforms upon dilution in chloride-containing buffer
salts to its di-chloro derivative and loses an oxalate molecule.
Consequently, the chloride ions exchange with water molecules in the
intracelllular environment to produce the di-aqua derivative, which is
the most active biotransformation product of Oxali in terms of forming
the DNA adducts. Thus, inhibiting transformation of di-chloro to di-aqua
derivatives by accumulating chloride ions at the site of extravasation
and saturating the Oxali molecule with these ions is a strategy that
could help manage extravasation. Injecting normal saline at this site is
a simple yet effective way to achieve this goal.... Show more Show less