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dc.contributor.authorBALTACI, Abdülkerim Kasım
dc.contributor.authorSUNAR, Füsun
dc.contributor.authorMOĞOLKOÇ, Rasim
dc.contributor.authorTOY, Hatice
dc.date.accessioned2019-07-09T12:55:57Z
dc.date.available2019-07-09T12:55:57Z
dc.date.issued2017-05
dc.identifier.citationThe Effect of Zinc Deficiency and Supplementation on Elements in the Kidney Tissue of Ovariectomized Rats: Histopathologic Changes By:Baltaci, AK (Baltaci, Abdulkerim Kasim)[ 1 ] , Sunar, F (Sunar, Fusun)[ 2 ] , Mogulkoc, R (Mogulkoc, Rasim)[ 1 ] , Toy, H (Toy, Hatice)[ 3 ] INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH Volume: 87 Issue: 3-4 Pages: 131-138 DOI: 10.1024/0300-9831/a000396 Published: MAY 2017 Document Type:Article View Journal Impact Abstract The objective of the present study is to determine the effects of zinc deficiency in and zinc supplementation to ovariectomized rats on some elements in kidney tissue. The study included 40 Sprague-Dawley type adult female rats. The experimental animals were randomized into four groups with equal numbers as follows: Group 1: Control (10). Group 2: Ovariectomized control (10). Group 3: Ovariectomized + zinc supplemented (10). Group 4: Ovariectomized + zinc deficient (10). After the animals were decapitated at the end of the experiment, element levels were determined by Atomic Emission (ICP-AES) as mg/g/wet tissue for calcium, phosphate, zinc, aluminum, copper, iron, lithium, and manganese and mu g/g/wet tissue for magnesium in the kidney tissue. Additionally, the tissue samples were subjected to a histopathologic assessment. An examination of the study results showed that ovariectomy significantly reduced calcium, phosphorus, and zinc levels, while zinc supplementation to the rats following ovariectomy restored the reduced element levels to normal (0.10 +/- 0.03, 0.85 +/- 0.16, 0.11 +/- 0.03 vs 0.19 +/- 0.06, 1.86 +/- 0.18, 0.52 +/- 0.05). Group 4, which was both ovariectomized and fed on a zinc-deficient diet, had significantly lower aluminum, copper, and lithium values. Calcification, inflammation, and sclerotic changes in group 4, the group which was fed on a zinc-deficient diet, were greater in comparison to other groups (p < 0.05). Results of the study suggest that ovariectomy + zinc deficiency leads to calcification, inflammation, and sclerotic changes in renal tissue and significantly reduces element levels, whereas zinc supplementation after ovariectomy restores the lowered element levels to normal. Keywords Author Keywords:Kidney, ovariectomy, zinc supplementation, zinc deficiency, elementsen_US
dc.identifier.issn0300-9831
dc.identifier.urihttps://hdl.handle.net/20.500.12498/880
dc.description.abstractThe objective of the present study is to determine the effects of zinc deficiency in and zinc supplementation to ovariectomized rats on some elements in kidney tissue. The study included 40 Sprague-Dawley type adult female rats. The experimental animals were randomized into four groups with equal numbers as follows: Group 1: Control (10). Group 2: Ovariectomized control (10). Group 3: Ovariectomized + zinc supplemented (10). Group 4: Ovariectomized + zinc deficient (10). After the animals were decapitated at the end of the experiment, element levels were determined by Atomic Emission (ICP-AES) as mg/g/wet tissue for calcium, phosphate, zinc, aluminum, copper, iron, lithium, and manganese and mu g/g/wet tissue for magnesium in the kidney tissue. Additionally, the tissue samples were subjected to a histopathologic assessment. An examination of the study results showed that ovariectomy significantly reduced calcium, phosphorus, and zinc levels, while zinc supplementation to the rats following ovariectomy restored the reduced element levels to normal (0.10 +/- 0.03, 0.85 +/- 0.16, 0.11 +/- 0.03 vs 0.19 +/- 0.06, 1.86 +/- 0.18, 0.52 +/- 0.05). Group 4, which was both ovariectomized and fed on a zinc-deficient diet, had significantly lower aluminum, copper, and lithium values. Calcification, inflammation, and sclerotic changes in group 4, the group which was fed on a zinc-deficient diet, were greater in comparison to other groups (p < 0.05). Results of the study suggest that ovariectomy + zinc deficiency leads to calcification, inflammation, and sclerotic changes in renal tissue and significantly reduces element levels, whereas zinc supplementation after ovariectomy restores the lowered element levels to normal.en_US
dc.language.isoen_USen_US
dc.publisherINTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCHen_US
dc.relation.ispartofseries87,10.1024/0300-9831/a000396
dc.subjectKidneyen_US
dc.subjectElements
dc.subjectZinc Deficiency
dc.subjectZinc Supplementation
dc.subjectOvariectomy
dc.titleThe Effect of Zinc Deficiency and Supplementation on Elements in the Kidney Tissue of Ovariectomized Rats: Histopathologic Changesen_US
dc.typeMakaleen_US


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