The Effect of the Application of Melatonin and Zinc in DMBA-Induced Mammary Carcinoma in Rats on Lipid Peroxidation and Element Metabolism

  • Yazar/lar GÜLBAHÇE MUTLU, Elif
    BALTACI, Saltuk Buğra
    MENEVŞE, Esma
    MOĞULKOÇ, Rasim
    BALTACI, Abdülkerim Kasım
  • Yayın Türü Konferans Bildirisi
  • Yayın Tarihi 2018
  • Yayıncı 3rd International Congress of Turkish Neuroendocrinology Society
  • Tek Biçim Adres https://hdl.handle.net/20.500.12498/1062

In this study, it was aimed to investigate the effects of application of melatonin and zinc on lipid peroxidation and elemental metabolism in female rats with DMBA-induced mammary carcinoma. The study groups were composed of control, DMBA control and treatment (DMBA+ zinc, DMBA + melatonin and DMBA + zinc+melatonin) groups. Female rats (except the control group) were given a strong carcinogen DMBA. After tumour formation, zinc and melatonin were administered to the treatment groups at a dose of 5 mg/kg/day for 4 weeks. MDA as an indicator of tissue damage and GSH levels as an indicator of antioxidant activity in blood and breast tissue samples were determined by spectrophotometric method. Besides, some serum element levels (iron, magnesium, zinc and copper) were calculated. The highest level of MDA found in plasma and breast tissue was obtained in the DMBA control group. Plasma MDA levels of the breast tissue were lower in the zinc group than in the melatonin group and significantly decreased in the zinc + melatonin group. Plasma MDA levels showed a significant decrease in the zinc + melatonin group, although there was no difference in the zinc and melatonin groups. The lowest GSH level found in erythrocytes and breast tissue was obtained in the DMBA control group. When zinc and melatonin groups were compared in the breast tissue, GSH level of zinc group was found to be higher than GSH level of melatonin group. Furthermore, the highest increase was found in the zinc + melatonin group. The highest levels of iron, magnesium and zinc were found in the zinc + melatonin group, and the highest level of copper was obtained in the DMBA control group. The findings showed that the antioxidant activity suppressed by increased oxidative damage in rat mammary carcinoma was improved, but the administration of zinc + melatonin gave better results.

Erişime Açık
Görüntülenme
90
22.03.2024 tarihinden bu yana
İndirme
1
22.03.2024 tarihinden bu yana
Son Erişim Tarihi
03 Aralık 2024 13:32
Google Kontrol
Tıklayınız
Tam Metin
Tam Metin İndirmek için tıklayın Ön izleme
Detaylı Görünüm
Eser Adı
(dc.title)
The Effect of the Application of Melatonin and Zinc in DMBA-Induced Mammary Carcinoma in Rats on Lipid Peroxidation and Element Metabolism
Yayın Türü
(dc.type)
Konferans Bildirisi
Yazar/lar
(dc.contributor.author)
GÜLBAHÇE MUTLU, Elif
Yazar/lar
(dc.contributor.author)
BALTACI, Saltuk Buğra
Yazar/lar
(dc.contributor.author)
MENEVŞE, Esma
Yazar/lar
(dc.contributor.author)
MOĞULKOÇ, Rasim
Yazar/lar
(dc.contributor.author)
BALTACI, Abdülkerim Kasım
Atıf Dizini
(dc.source.database)
Diğer
Yayıncı
(dc.publisher)
3rd International Congress of Turkish Neuroendocrinology Society
Yayın Tarihi
(dc.date.issued)
2018
Kayıt Giriş Tarihi
(dc.date.accessioned)
2019-07-10T08:29:55Z
Açık Erişim tarihi
(dc.date.available)
2019-07-10T08:29:55Z
Özet
(dc.description.abstract)
In this study, it was aimed to investigate the effects of application of melatonin and zinc on lipid peroxidation and elemental metabolism in female rats with DMBA-induced mammary carcinoma. The study groups were composed of control, DMBA control and treatment (DMBA+ zinc, DMBA + melatonin and DMBA + zinc+melatonin) groups. Female rats (except the control group) were given a strong carcinogen DMBA. After tumour formation, zinc and melatonin were administered to the treatment groups at a dose of 5 mg/kg/day for 4 weeks. MDA as an indicator of tissue damage and GSH levels as an indicator of antioxidant activity in blood and breast tissue samples were determined by spectrophotometric method. Besides, some serum element levels (iron, magnesium, zinc and copper) were calculated. The highest level of MDA found in plasma and breast tissue was obtained in the DMBA control group. Plasma MDA levels of the breast tissue were lower in the zinc group than in the melatonin group and significantly decreased in the zinc + melatonin group. Plasma MDA levels showed a significant decrease in the zinc + melatonin group, although there was no difference in the zinc and melatonin groups. The lowest GSH level found in erythrocytes and breast tissue was obtained in the DMBA control group. When zinc and melatonin groups were compared in the breast tissue, GSH level of zinc group was found to be higher than GSH level of melatonin group. Furthermore, the highest increase was found in the zinc + melatonin group. The highest levels of iron, magnesium and zinc were found in the zinc + melatonin group, and the highest level of copper was obtained in the DMBA control group. The findings showed that the antioxidant activity suppressed by increased oxidative damage in rat mammary carcinoma was improved, but the administration of zinc + melatonin gave better results.
Yayın Dili
(dc.language.iso)
eng
Tek Biçim Adres
(dc.identifier.uri)
https://hdl.handle.net/20.500.12498/1062
Analizler
Yayın Görüntülenme
Yayın Görüntülenme
Erişilen ülkeler
Erişilen şehirler
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve cerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms