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dc.contributor.authorGülbahçe Mutlu, Elif
dc.contributor.authorBaltacı, Saltuk Buğra
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.date.accessioned2019-07-10T08:33:00Z
dc.date.available2019-07-10T08:33:00Z
dc.date.issued2018-10-30
dc.identifier.urihttps://hdl.handle.net/20.500.12498/1066
dc.description.abstractABSTRACT: The aim of the present was study determine the effects of zinc and melatonin on brain tissue (cortex) lipid peroxidation in rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). Total 42 female wistar rats which was just weaned from milk equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+ Zinc, Group 4 DMBA + Melatonin, Group 5 DMBA + Zinc +Melatonin. To induce breast cancer 80 mg/kg DMBA was given by gavage in colza oil (except group 1). Zinc and melatonin were supplemented as 5 mg/kg/day for 4 weeks. Brain tissue samples (cortex) were examined for MDA and GSH be spectrophotometrics. The highest MDA levels were determined in group 2 which induced breast cancer (p<0.05). DMBA+Zinc, DMBA+Melatonin and DMBA+Zinc+Melatonin groups have lower MDA levels compared to DMBA control (p<0.05). GSH levels of zinc, melatonin and zinc + melatonin groups have higher than DMBA control group (p<0.05). The results of present study show that increased cortex damage by DMBA prevented by zinc, melatonin and zinc+melatonin. Combine supplementation of zinc and melatonin may contribute to preventing of tissue damage in tumoral condition.en_US
dc.language.isoenen_US
dc.publisherInternatıonal Academic Research Congress (INES-2018)en_US
dc.subjectbreast canceren_US
dc.subjectbrain tissueen_US
dc.subjectlipid peroxidationen_US
dc.subjectzincen_US
dc.subjectmelatoninen_US
dc.titlePrevention of Increased Brain Cortex Damage by Zinc and Melatonin in Rats with Breast Cancer induced by DMBAen_US
dc.typeOtheren_US


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