Cerebral Ischemia Reperfusion Injury in Rats: Effect of 3’,4’-Dihydroxyflavonol
Moğulkoç, Rasim; Baltacı, Abdulkerim Kasım; Menevşe, Esma; Baltacı, Saltuk Buğra; Gülbahçe Mutlu, Elif
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Abstract
The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on
experimental brain ischemia-reperfusion in rats. The study was performed on the 34 male Wistar-albino rats,
weigth 350-400 gr. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; 3-DiOHF+Ischemiareperfusion;
4-Ischemia+DiOHF+Reperfusion; 5- Ischemia-reperfusion+DiOHF. DiOHF was given to animals
as 10 mg/kg by intraperitoneal. Cerebral cortex was analyzed for malondyaldehyde (MDA), NO (niitric oxide),
xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Tissue MDA levels were
significantly higher ischemia-reperfusion groups (p<0.005). However, DiOHF inhibited MDA. Ischemiareperfusion
led to increased XO and NO but DiOHF supplementation reduced NO and XO. DiOHF increased
GSH and GPx levels compared to ischemia-reperfusion group. Our present study showed that intraperitoneal
DiOHF supplementation has protective effect on brain ischaemi-reperfusion injury in rat.... Show more Show less