Effect of 3’-4’-dihydroxyflavonol on lipid per oxidation inexperimental renal ischemia-reperfusion in rats
Date
2019Author
KOÇ, Aynur
ERGENE, Neyhan
BALTACI, Abdülkerim Kasım
MOĞULKOÇ, Rasim
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This study aimed to examine the affects of 3’-4’-dihydroxyflavonol (DiOHF) on lipid peroxidation in
experimental renal ischemia-reperfusion. The research was conducted on Wistar-albino type male rat. The experimental
groups were formed as 1.Control; 2.Sham; 3.Ischemia; 4.Ischemia+reperfusion; 5.DiOHF+Ischemia; 6.Ischemia+
DiOHF + reperfusion. The highest tissue glutathione levels were found in groups 5 and 6. Groups 1 and 2, which were
control and sham groups respectively, had the lowest tissue GSH values. Ischemia group was found to have the highest
tissue malondialdehyde (MDA) level. Tissue MDA levels in group 4 were lower than those in group 3, however, higher
than the levels in all other groups. Erythrocyte GSH levels in groups 5 and 6 were higher than the levels in all other
groups. Group 4 has highest plasma MDA values. Plasma MDA levels in group 3 were lower than the levels in Group 4,
but higher than those in other groups. The results of the study indicate that intraperitoneal DiOHF administration inhibits
lipid per oxidation that intensifies in the case of renal ischemia-reperfusion injury in rats.
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