Examining The Antitumoral Effect of Cornelian Cherry (Cornus Mas) in Ehrlich Ascites Tumor-Induced Mice

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Date
2019Author
YILMAZ, Seher
ALPA, Şerife
NİSARİ, Mehtap
ŞEKER KARATOPRAK, Gökçe
ÜLGER, Harun
ERTEKİN, Tolga
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Introduction: Different doses of C. Mas concentrated syrup on ascitic tumors was investigated in the
Ehrlich Ascites Tumor model (EAT). Material and Methods: A total of 46 Balb/C mice were used in
our study, 6 of which were stock animals and the other were in ascitic tumor groups. EAT cells (1x106
EAT cells) were injected intraperitoneally into all of the mice. Mice in the treatment groups with
ascitic tumors received 100 mg/kg and 200 mg/kg Cornus Mas extract intraperitoneally for 9 days.
Results: Counts after the 3 and 24-hour incubations in the EAT cell line that the average number of the
dead cells was less in the group to which 100µg/ml C. Mas was administered when compared with the
control group, and that this difference was significant at a statistical level (P<0.05). The purpose was
also to determine the in vitro cytotoxic effects of Cornus Mas on EAT cells, to define the alive and dead
cell rates, and to compare the 3-hour and 24-hour incubation in groups to which Cornus Mas (syrup)
extract were given at different concentrations (50, 100, 250μg/ml). Discussion and Conclusion: EAT
model is one of the animal tumors induced empirically, it has been the subject matter of many other
studies. In the group in which EAT was applied together with high-dose C. mas fruit syrup, it was
observed that the EAT cells were not as intense as they were in the tumor control group. Our study
showed the anti-tumor effect of C. Mas in assisted tumor development with EAT cells.
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