ŞİZOFRENİ HASTALARININ KAN TAHLİL SONUÇLARI İLE CORPUS CALLOSUM ANATOMİSİNİN İLİŞKİLENDİRİLMESİ

Abstract

Corpus callosum is the white part of the brain that allows communication between the two hemispheres of the brain. Schizophrenia is a clinically and biochemically sophisticated disorder characterized by deformation in mental functions. In the study, we aimed to examine biochemical mechanisms of the disorder and the correlation of these mechanisms with corpus callosum. The study included a total of 39 individuals (16 female, 23 male) with schizophrenia who were diagnosed by DSM-IV diagnosis axis. Over the magnetic resonance (MR) images of the patients, the length, angle, area and volume values of corpus callosum was measured. Complete blood and hormone tests dated the same as MR images were noted retrospectively. Whether a correlation exists between corpus callosum measurements and blood results was studied. From the findings, we found the values of fasting blood glucose and Low-Density Lipoprotein (LDL) were positively correlated with some length values at corpus callosum. Triglyceride was negatively correlated with some angular values. Thyroid Stimulating Hormone (TSH) was positively correlated with some length and area values, but negatively correlated with angular values. Triiodothyronine (fT3) was positively correlated with some length and angular values, but it was negatively correlated with area values. Thyroxine (fT4) was negatively correlated with some of length values. Alanine aminotransferase (ALT) was negatively correlated with some length values while it was positively correlated with some other length values. It was also negatively correlated with angular values. Aspartate aminotransferase (AST) values had no significant correlation with any measurement value. Consequently, we are of the opinion that our findings are vital for a better understanding of clinical and neurobiochemical structure of the disease, however, more studies about the subject are needed to develop new treatment strategies.