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Bulunan: 40 Adet 0.002 sn
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Bulunan: 40 Adet 0.002 sn
Tam Metin [1]
Atıf Dizini [4]
Yayın Dili [3]
dc.description.provenance [19]
Doç. Dr. Merve Aydın TerzioğluKTO KARATAY ÜNİVERSİTESİ/TIP FAKÜLTESİ/TEMEL TIP BİLİMLERİ BÖLÜMÜ/TIBBİ MİKROBİYOLOJİ ANABİLİM DALI/
Süresiz Ambargo

Identification of medically important yeasts by sequence analysis of the internal transcribed spacer and D1/D2 region of the large ribosomal subunit

AYDIN, Merve | KUŞTİMUR, Semra | KALKANCI, Ayşe | DURAN, Tuğçe

Background: The prevalence of opportunistic yeast infections has increased in recent decades as the resultof an increasing immunocompromised patient population.Aims: To evaluate ribosomal RNA (rRNA) gene sequence to identify medically important yeast species, toinvestigate the performance of both the rRNA gene internal transcribed spacer (ITS) and D1/D2 region in identifying clinically relevant yeasts, and to compare these results with those of a standard phenotypicmethod.Methods: Both regions from 50 yeast strains, comprising 45 clinical isolates and 5 reference strains, wereamplified using P ...Daha fazlası

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Molecular characterization and subtyping of Blastocystis in urticarial patients in Turkey

AYDIN, Merve | YAZICI, Mustafa | DEMİRKAZIK, Mehtap | KOLTAŞ, İsmail Soner | ÇIKMAN, Aytekin | GÜLHAN, Barış | DURAN, Tuğçe | YILMAZ, Aysun | KARA, Murat

Objective: To investigate Blastocystis’ etiologic role and association with gastrointestinal symptomatology in acute and chronic urticaria patients and to identify Blastocystis subtypes responsible for urticaria. Methods: The study included urticaria patients and healthy individuals that presented to our polyclinic between June 2015 and May 2017. The participants were assigned into Group I (137 patients), subdivided into acute (72) and chronic urticaria patients (65), and Group II (129 control individuals). Blastocystis presence was investigated by native-Lugol examination, trichrome staining, ...Daha fazlası

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Bir Eğitim ve Araştırma Hastanesinde Kesici ve Delici Alet Yaralanmalarının Değerlendirilmesi

DİZİLİ YELGİN, Canan | ÇIKMAN, Aytekin | KARAKEÇİLİ, Faruk | GÜLHAN, Barış | AYDIN, Merve

Amaç: Bu çalışmada bir eğitim ve araştırma hastanesindeki kesici ve delici alet yaralanmaları retrospektif olarak incelenmiş ve mevcut durumun tespit edilip konu hakkında sonuç ve önerilere ulaşılması amaçlanmıştır. Yöntemler: Veriler, ilgili tarihlerde kesici ve delici alet yaralanmasına maruz kalmış ve infeksiyon kontrol komitesi birimine başvurmuş olan 124 sağlık çalışanının 18 adet soru içeren bildirim formlarından elde edilmiştir. Tüm verilerin istatistiksel analizi yapılmış ve p değeri 30 yaş grubunda yaralanmalar daha çok klinik servis ve ameliyathanelerde gerçekleşmiştir. Çalışmamızda ...Daha fazlası

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Absence of the mecC gene in methicillin-resistant Staphylococcusaureus isolated from various clinical samples: The first multi-centeredstudy in Turkey

ÇIKMAN, Aytekin | AYDIN, Merve | GÜLHAN, Barış | KARAKEÇİLİ, Faruk | KURTOĞLU, Muhammet Güzel | YÜKSEKKAYA, Şerife | PARLAK, Mehmet | GÜLTEPE, Sümbül Bilge | ÇOPUR ÇİÇEK, Ayşegül | BAYINDIR BİLMAN, Fulya | ÇİFTÇİ, İhsan Hakkı | KARA, Murat | ATMACA, Selahattin | ÖZEKİNCİ, Tuncer

tBackground: mecA is a predefined gene causing methicillin resistance in Staphylococcus aureus (S. aureus)isolates; however, it has been shown that some methicillin-resistant S. aureus (MRSA) strains do notcarry this gene. Recently, in isolates found to be MRSA-positive but mecA-negative, a new resistance gene called mecC, which is a homolog of mecA, has been reported. This study aimed to investigate the mecCand mecA genes in MRSA strains isolated from different geographic regions in Turkey.Methods: The sample of the study consisted of 494 MRSA strains isolated from seven geographical regionsi ...Daha fazlası

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Mikobakteriler

SARIBAŞ, Suat | AYDIN, Merve

Mycobacterium cinsi, tümünün aside dirençli boyanma özelliği gösterdiği gram-pozitif basil türlerini içerir. Önemli bir tür olan Mycobacterium tuberculosis (MTB), Dickens zamanında tüketici, korkunç bir hastalık olarak nitelendirilen tüberküloz (verem) etkenidir. Çoğu zengin ülkeler dışında olmak üzere, tüberküloz, dünya nüfusunun hâlâ üçte birini enfekte etmekte ve her yıl yaklaşık 2 milyon kişinin ölümüne neden olmaktadır. Mycobacterium leprae, eski ve şekil bozucu bir hastalık olan lepra (cüzzam) etkenidir. Daha az patojenik olan çok sayıda tür ise, başta AIDS olmak üzere immün yetmezliği o ...Daha fazlası

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Borrelia burgdorferi chemotaxis toward tick protein Salp12 contributes to acquisition

MURFIN, Kristen E. | KELINBARD, Ruby | AYDIN, Merve | SALAZAR, Samuel A. | FIKRIG, Erol

Lyme disease is a common tick-borne infection caused by the spirochete Borrelia burgdorferi sensu stricto (s.s.). B. burgdorferi s.s. may utilize chemotaxis, the directional migration towards or away from a chemical stimulus, for transmission, acquisition, and infection. However, the specific signals recognized by the spirochete for these events have not been defined. In this study, we identify an Ixodes scapularis salivary gland protein, Salp12, that is a chemoattractant for the spirochete. We demonstrate that Salp12 is expressed in the I. scapularis salivary glands and midgut and expression ...Daha fazlası

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In vitro anti-candidal and anti-biofilm activity of new ethane sulfonyl hydrazone compound

ÖZTÜRK, Ali | AYDIN, Merve | ÖZDEMİR ÖZMEN, Ümmühan

Candida species cause cutaneous and systemic infections with a high mortality rate, especially in immunocompromised patients. However, the emergence of resistance to the most common antifungal drugs, also due to biofilm formation, there is an increasing need to design new and more effective antifungals with less toxic. Sulfonyl hydrazones are well-known for their pharmacological effects, such as antifungal and antibacterial potential and can act as an antinociceptive, antidepressant, antineoplastic activity. The aim of this study was to investigate the anti-candidal and anti-biofilm activity o ...Daha fazlası

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In vitro antifungal and antibiofilm activities of new butane sulfonyl hydrazone compound against medically important yeast

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | ÖZDEMİR ÖZMEN, Ümmühan

The prevalence of fungal infections has increased in the last two decades in parallel with the increasing number of immunosuppressed patients. The excessive use of antifungal agents is causing the accumulation of multi-resistance phenotypes in many fungal strains. Consequently, new alternative agents to conventional antifungal agents are urgently needed to prevent the emergence of fungal resistance. Sulfonyl hydrazone derived from sulfonamide, are well-known for their pharmacological effects, such as antifungal, antibacterial potential, and antineoplastic activity. This study aimed to investig ...Daha fazlası

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Role of ozone therapy in preventing testicular damage in an experimental cryptorchid rat model

BİÇER, Şenol | GÜRSUL, Cebrail | SAYAR, İlyas | AKMAN, Orhan | ÇAKARLI, Seçil | AYDIN, Merve

Background: Cryptorchidism is the most common developmental abnormality of the male reproductive system. If left untreated, it results with infertility and testicular cancer. According to current evidence, surgery is the mainstay of treatment, and hormonal therapy approaches are still under investigation. For the protection of testicular functions, antioxidants have emerged as novel options. This study aimed to evaluate the protective properties of ozone, a strong antioxidant, on testicular tissue. Material/Methods: Thirty-five male Wistar-albino rats, 1-month-old, were used for the study. Gro ...Daha fazlası

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Asymptomatic dermatophyte scalp carriage in school children in Erzincan, Turkey

AYDIN, Merve | GÜLHAN, Barış | GÜMRAL, Ramazan | İLKİT, Macit | ÖZTÜRK, Ali

Background: This study aimed to investigate the prevalence of symptomatic tinea capitis infections of the scalp and its asymptomatic carriage in students attending primary schools in Erzincan, Turkey. Materials and Methods: Eighteen primary schools were visited; 1 located in the central district and 17 located in other districts of the Erzincan province. From 2015 November to 2016 April, scalp scrapings were obtained from a total of 1879 students aged 6 to 13 years (mean age: 9.37±1.69) 924 (49.2%) male and 955 (50.8%) female using sterile hairbrushes, and assessed for tinea capitis and asympt ...Daha fazlası

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Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients

KARAKEÇİLİ, Faruk | ÇIKMAN, Aytekin | AYDIN, Merve | GÜLHAN, Barış

BACKGROUND: High asymmetrical dimethylarginine (ADMA) levels have been associated with endothelial dysfunction and contribute to the development of several diseases. However, data on the relationship between hepatitis B virus (HBV) and ADMA are limited. The aim of our study was to explore the relationship between ADMA and HBV by comparing the ADMA levels in patients with chronic active hepatitis B (CHB), inactive HBV carriers (carriers), and healthy volunteers (controls). METHODS: The participants were divided into three groups: 90 patients with CHB, 90 HBV carriers, and 90 controls. Serum ADM ...Daha fazlası

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The evaluation of oxidative stress parameters in the benign prostatic hyperplasia, prostatitis and prostate cancer

BOZKURT, Aliseydi | GÜRSUL, Cebrail | AYDIN, Merve | SAYAR, İlyas | KARABAKAN, Mehmet | ÇIKMAN, Aytekin

Aim: Recently, oxidative stress has been well known that it has especially important a role in benign prostatic hyperplasia, prostatitis, and prostate cancer. The present study has planned to estimate parameters of the oxidative stress and the antioxidant status in patients with benign prostatic hyperplasia, prostatitis and prostate cancer. Material and Method: For this aim totally fourty men with benign prostatic hyperplasia (n=14), prostatitis (n=15) and prostate cancer (n=11) without any other chronic disease, and who not use cigarettes and alcohol were subjected. Venous blood samples were ...Daha fazlası

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