Neuroprotective Effects Of High-Dose Human Albumin Against Traumatic Spinal Cord İnjury in Rats

BACKGROUND AND OBJECTIVES: Human serum albumin (HA) is a unique multifunctional protein with neuroprotective properties. We aimed to delineate the mechanisms of HA-induced neuroprotection, supresses inflammatory response and lipid peroxidation after spinal cord injury (SCI). METHODS AND STUDY DESIGN: Adult female Wistar rats weighing 210-250 g were used for the study. The rats were randomly and blindly allocated into five groups. The one-way analysis of variance (ANOVA) for parametric data and Shapiro-Wilk test was used for evaluating the normal distribution of the variables. Kruskal-Wallis for nonparametric data was used to compare groups. Electron and light microscopies were used to demonstrate ultrastructural changes in spinal cord. RESULTS: The HA group was significantly different from all the other groups (p < 0.05). Both MPSS and HA treatments decreased the MPO significantly. HA treatment decreased the lipid peroxidation. HA treatment prevented the worsening of clinical results. In the HA treatment group, the ultrastructure was protected significantly. The neuronal bodies and axonal structures were normal except for some limited edematous spaces. CONCLUSIONS: HA improves early clinical results, protects spinal cord ultrastructure, and decreases MPO and LPO levels after spinal cord contusion injury. © 2018 Bratislava Medical Journal.

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Eser Adı
(dc.title)
Neuroprotective Effects Of High-Dose Human Albumin Against Traumatic Spinal Cord İnjury in Rats
Yayın Türü
(dc.type)
Makale
Yazar/lar
(dc.contributor.author)
YILDIRIM, Timur
Yazar/lar
(dc.contributor.author)
OKUTAN, Özerk
Yazar/lar
(dc.contributor.author)
AKPINAR, Elif
Yazar/lar
(dc.contributor.author)
YILMAZ, Ali
Yazar/lar
(dc.contributor.author)
IŞIK, Hasan Serdar
DOI Numarası
(dc.identifier.doi)
10.4149/BLL_2018_016
Atıf Dizini
(dc.source.database)
Scopus
Konu Başlıkları
(dc.subject)
Human Albumin
Konu Başlıkları
(dc.subject)
Rats
Konu Başlıkları
(dc.subject)
Spinal Cord Injury
Yayıncı
(dc.publisher)
Comenius University
Yayın Tarihi
(dc.date.issued)
2018
Kayıt Giriş Tarihi
(dc.date.accessioned)
2020-08-07T12:53:48Z
Açık Erişim tarihi
(dc.date.available)
2020-08-07T12:53:48Z
Kaynak
(dc.source)
Bratislava Medical Journal
ISSN
(dc.identifier.issn)
00069248 (ISSN)
Özet
(dc.description.abstract)
BACKGROUND AND OBJECTIVES: Human serum albumin (HA) is a unique multifunctional protein with neuroprotective properties. We aimed to delineate the mechanisms of HA-induced neuroprotection, supresses inflammatory response and lipid peroxidation after spinal cord injury (SCI). METHODS AND STUDY DESIGN: Adult female Wistar rats weighing 210-250 g were used for the study. The rats were randomly and blindly allocated into five groups. The one-way analysis of variance (ANOVA) for parametric data and Shapiro-Wilk test was used for evaluating the normal distribution of the variables. Kruskal-Wallis for nonparametric data was used to compare groups. Electron and light microscopies were used to demonstrate ultrastructural changes in spinal cord. RESULTS: The HA group was significantly different from all the other groups (p < 0.05). Both MPSS and HA treatments decreased the MPO significantly. HA treatment decreased the lipid peroxidation. HA treatment prevented the worsening of clinical results. In the HA treatment group, the ultrastructure was protected significantly. The neuronal bodies and axonal structures were normal except for some limited edematous spaces. CONCLUSIONS: HA improves early clinical results, protects spinal cord ultrastructure, and decreases MPO and LPO levels after spinal cord contusion injury. © 2018 Bratislava Medical Journal.
Yayın Dili
(dc.language.iso)
en
Tek Biçim Adres
(dc.identifier.uri)
http://hdl.handle.net/20.500.12498/2906
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