|dc.contributor.author||Murfin, Kristen E. and Kleinbard, Ruby and Aydin, Merve and Salazar,
Samuel A. and Fikrig, Erol||
|dc.description.abstract||Lyme disease is a common tick-borne infection caused by the spirochete
Borrelia burgdorferi sensu stricto (s.s.). B. burgdorferi s.s. may
utilize chemotaxis, the directional migration towards or away from a
chemical stimulus, for transmission, acquisition, and infection.
However, the specific signals recognized by the spirochete for these
events have not been defined. In this study, we identify an Ixodes
scapularis salivary gland protein, Salp12, that is a chemoattractant for
the spirochete. We demonstrate that Salp12 is expressed in the I.
scapularis salivary glands and midgut and expression is not impacted by
B. burgdorferi s.s. infection. Knockdown of Salp12 in the salivary
glands or passive immunization against Salp12 reduces acquisition of the
spirochete by ticks but acquisition is not completely prevented.
Knockdown does not impact transmission of B. burgdorferi s.s. This work
suggests a new role for chemotaxis in acquisition of the spirochete and
suggests that recognition of Salp12 contributes to this phenomenon.||
|dc.source||TICKS AND TICK-BORNE DISEASES||
|dc.title||Borrelia burgdorferi chemotaxis toward tick protein Salp12 contributes