The Relationship Between Serum Asprosin Levels and Cardiovascular Risk Factors In Patients With Chronic Kidney Disease

TÜRKMEN, Kültigin | EROĞLU, Canan | ÇALIŞKAN SAK, Kaniye Zeynep | BALOĞLU, İsmail | KURAR, Ercan | KUTLU, Selim

Objective: The aim of this study was to determine serum asprosine levels in stage 3 and 4 chronic kidney disease (CKD) patients and healthy individuals and to investigate the relationship between this parameter and cardiovascular risk factors. Materials-Methods: In our investigation, serum and plasma samples from blood taken for standard laboratory testing were employed. In all, 91 people were involved in our investigation. Thirtyseven of these were patients with stage 3 CKD, twenty with stage 4 CKD, and 37 were healthy controls. Serum from both healthy and CKD participants was used to perform ...Daha fazlası

The 21st Century Skills of Prep Students

TAYTAK ÜN, Gülberk

This descriptive study aims to investigate prep students’ perception of 21st Century Skills that have gained a great significance recently as a result of major developments in technology which has an impact on every field of life. These skills also required some innovations in the field of education, and Foreign Language education, which is based on communication, also includes some innovations as a natural consequence of this situation. While students of bachelor’s degree were expected to have only sufficient academic knowledge in the past, nowadays it’s a must for a person to have some quali ...Daha fazlası

In Vitro Activity of Coenzymeq10 Loaded Mesoporous Silica Nanoparticles Against Mcf-7 Cells

GÜLBAHÇE MUTLU, Elif | ŞEFLEK, Hatice Nur | ALPA, Şerife | ERTUŞ, Emre Burak | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur

Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası

Determination of Cytoxic Effects of Diazepam and Flumazenil in MCF-7 Cell Line

TÜRKOĞLU, Fatma Nur | ALPA, Şerife | GÜLBAHÇE MUTLU, Elif | ERBAYRAM, Fatma Zehra | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, the second most common cause of cancer death, is a global public health problem due to its poor response to treatment and complex aetiology. The MCF-7 cell line is widely used in laboratories around the world for in vitro studies to address this problem. Diazepam is one of the most successful anaesthetics since the beginning of the psychopharmacological revolution. It belongs to a class of benzodiazepines that is often preferred in anaesthesia. Flumazenil is an imidazobenzodiazepine and was the first benzodiazepine antagonist to enter clinical use. The e ...Daha fazlası

Determination Of Cytoxic Effects Of Oxytocin And Atosiban Mcf-7 Cell Line

ERBAYRAM, Fatma Zehra | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | TÜRKOĞLU, Fatma Nur | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, a major cause of cancer-related deaths, is an important health problem due to its inadequate response to treatment and complex etiology. Oxytocin (OT) is a peptide mammalian hormone consisting of nine amino acids. Today, cellular studies of oxytocin have gained importance. Oxytocin has been observed to inhibit cell proliferation in cancer. The biggest advantage of oxytocin therapies is that they provide the organism with cell production on its own and have no side effects. Studies have shown that OT is a factor that stimulates cell proliferation in lung, ...Daha fazlası

Determination of The Cytotoxic Effect of Propylthiouracil Loaded Mesoporous Silica on Mcf-7 Cell Line

GÜLBAHÇE MUTLU, Elif | ŞEFLEK, Hatice Nur | ALPA, Şerife | ERTUŞ, Emre Burak | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur

Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası

Semen Microbiome Dysbiosis In Male Infertility

ŞEFLEK, Hatice Nur | ERBAYRAM, Fatma Zehra | TOKAK, Semik

Infertility is a major health problem and is increasing worldwide. The shift in the age at which both partners have their first child to older ages and lifestyle changes have contributed to the increase in the incidence of infertility. 50% of infertility in couples is due to male infertility. In vitro studies show that bacteria can negatively affect sperm function. Bacteria; has been shown to play an important role in many mechanisms that affect sperm function, including agglutination of motile sperm, induction of apoptosis, production of immobilization factors, and disruption of acrosome resp ...Daha fazlası

The Effect Of Coenzyme Q10 Administration On The Expression Of Some Genes In Rats With Hypothroidia

ŞEFLEK, Hatice Nur | GÜLBAHÇE MUTLU, Elif | CÜCE, Gökhan | KALKAN, Serpil

Introduction: Hypothyroidism is an endocrine disorder that occurs mainly due to the insufficiency of thyroid hormones in the body or the inability of these hormones to affect target tissues. As a result of the insufficiency of thyroid hormones, the systems are affected and accordingly, the health status of individuals is adversely affected. Coenzyme Q10 is a lipophilic antioxidant that plays a role in membrane stability, energy conversion and ATP production. The aim of this study was to determine the effect of Coenzyme Q10 on GDNF, PLZF, SOX3 and THY1 gene expression levels in rats with hypoth ...Daha fazlası

Determination of Antioxidant and Anticancer Activities of C. Sativa Leaf Extracts on MCF7 Human Breast Cancer Cell Line

BEYAZYÜZ, Fadime | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur | KULAÇ, Şemsettin

Aim: In this study, it was aimed to determine the total phenolic content, flavonoid content, and antioxidant activity of Castanea sativa Mill. (chestnut) leaf extract and their anti-proliferative effect on MCF 7 cell line. Materials and Methods: It determined antioxidant capacities by using DPPH assay, total phenolic content by using Folin-Ciocaltaeu method and Total flavonoid content by aluminum chloride colorimetric method in the ethanolic extracts of Chesnut leaf. In addition, the anti-proliferative effect of chestnut leaf extract was determined by XTT method in MCF7 breast cell line. The l ...Daha fazlası

The Effects of Oil Price Shocks on Clean Energy and Oil and Gas Stock Returns

UÇKUN ÖZKAN, Ayşegül

This study empirically examines how fluctuations in oil prices affect the stock returns of clean energy and oil and gas companies between 2001:01 and 2022:06. Our results show that a negative oil supply shock affects the stock returns of clean energy companies positively. In contrast, an oil-specific demand shock negatively affects them. The findings also reveal that an increase in oil prices owing to an oil-specific demand shock tends not to improve the stock returns of oil and gas companies. Consequently, the results indicate that oil and clean energy are not alternatives.

The impact of investor attention on green bond returns: How do market uncertainties and investment performances of clean energy and oil and gas markets affect the connectedness between investor attention and green bond?

UÇKUN ÖZKAN, Ayşegül

This paper empirically investigates the spillover between investor attention and green bond returns by utilizing the connectedness approach. We will examine the impact of uncertainty in the stock, bond, and energy markets, as well as the success of clean energy, oil, and gas investments, on the relationship between green bonds and investor attention. We find that there are positive but small spillovers between investor attention and green bond returns. Besides, the connectedness between investor attention and green bond market performance is stronger in the short run than in the long run. Furt ...Daha fazlası

Sustainable supplier selection during micro crises in the manufacturing indutry: An application for the automotive spare parts indutry

ÇİZMECİOĞLU, Sinan | ÇALIK, Ahmet