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dc.contributor.authorGÜLBAHÇE MUTLU, Elif
dc.contributor.authorBALTACI, Saltuk Buğra
dc.date.accessioned2021-01-22T08:41:40Z
dc.date.available2021-01-22T08:41:40Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/20.500.12498/4975
dc.description.abstractThe purpose of this study was to investigate the effects of zinc and melatonin administration on lipid peroxidation in various tissues in DMBA-induced breast cancer in female rats. A total of 42 recently weaned Wistar rats were divided into 5 groups in the study: Group 1 (Control), Group 2 (DMBA Control), Group 3 (DMBA+Zinc), Group 4 (DMBA+Melatonin), Group 5 (DMBA+Melatonin, and Zinc). MDA (malondialdehyde) and GSH (glutathione) levels were determined via the spectrophotometric method in the lung, liver, spleen, pancreas, and kidney tissue samples taken from experimental animals. The highest lung, liver, spleen, pancreas, and kidney tissue MDA levels were obtained in the DMBA-induced breast cancer group control group (G2) (p<0.05). MDA levels in DMBA+Zinc (G3), DMBA+Melatonin (G4), and DMBA+Melatonin and Zinc (G5) were significantly lower than group 2 (p<0.05). Similarly, lung, liver, spleen, pancreas, and kidney tissue GSH levels of DMBA+Zinc (G3), DMBA+Melatonin (G4), and DMBA+Melatonin and Zinc (G5) were significantly higher than that of Group 2 (p<0.05). The findings of the study indicated that increased lung, liver, spleen, pancreas, and kidney damage in DMBA-induced breast cancer is suppressed with the supplementation of zinc, melatonin, and combined zinc and melatonin.en_US
dc.language.isoenen_US
dc.publisherBiointerface Researchen_US
dc.subjectDMBAen_US
dc.subjectbreast canceren_US
dc.subjectMDAen_US
dc.subjectGSHen_US
dc.subjectZincen_US
dc.subjectMelatoninen_US
dc.titleThe Effect of Zinc and Melatonin Supplementation on Lipid Peroxidation of Various Tissues of Rats with by DMBA-Induced Breast Canceren_US
dc.typeArticleen_US


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