The investigation of the antitumoral effect of Cornus mas L in mice with ehrlich solid tumor

YILMAZ, Seher | ALPA, Şerife | GÖÇMEN, Ayşe Yeşim | ÜLGER, Harun | ARSLAN, Esra | YAY, Arzu Hanım | ERTEKİN, Tolga | NİSARİ, Mehtap | YALÇIN, Betül

AIM: Cornus mas L is commonly used due to its anti-inflammatory, anti-carcinogenic and anti-oxidant properties. In the study, the effects of C. mas L extract on a solid tumor were examined in the Ehrlich solid tumor model developed in Balb/C type mice. METHODS: Ehrlich acid tumor (EAT) cells (1x106 EAT cell) from the stock animal were injected subcutaneously (s.c.) through the nape of the mice. Treatment groups of solid tumor-induced animals received 100 mg/kg and 200 mg/kg of C. mas L extract intraperitoneally (i.p.) for 14 days. RESULTS: Tumor volumes and animal weights were found to be stat ...Daha fazlası

Utilization of Waste for Energy Generation in Clinker Production: Environmental Perspective

TUNÇEZ, Fatma Didem

Meeting the increasing energy need from fossil fuels such as coal, oil and natural gas caused the rapid depletion of natural resources. In a world where the need for energy is constantly increasing and resources are getting scarce, it is necessary to ensure the sustainability of energy. Clinker production is a process which require high amount of energy in manufacturing industry. The fact that energy is mostly obtained from coal, which is a non-renewable fuel, puts the future of the sustainability of cement production at risk. Alternative fuel usage plays the most important role in achieving m ...Daha fazlası

Fluoroscopy-guided genicular nerves pulsed radiofrequency for chronic knee pain treatment

ARICAN, Şule | HACIBEYOĞLU, Gülçin | AKKOYUN SERT, Özlem | TUNCER UZUN, Sema | REİSLİ, Ruhiye

Objectives: The primary objective of this study was to investigate the effects of Pulsed RF application in the genicular nerve on pain and function in patients with osteoarthritis (OA) and its side effects. Methods: This study was conducted between February 2018 and June 2018. Patients who were previously administered diagnostic blocks were evaluated a day later; a drop of at least 50% in numeric pain scores was considered a positive response, and these patients were included in the Pulsed RF neurotomy procedures. Radiofrequency (RF) cannula was advanced towards targeted nerves under the guida ...Daha fazlası

Proanthocyanidins in grape seeds: An updated review of their health benefits and potential uses in the food industry

ÜNÜSAN, Nurhan

Grape seeds are rich sources of proanthocyanidins, which comprise polyhydroxyflavan oligomers or polymers. The beneficial health properties of grape seed proanthocyanidins are attributed to their conjugated and colonic metabolites. There is potential for a two-way relationship between the gut microbiota and grape seed proanthocyanidin. In particular, numerous in vitro and in vivo studies have demonstrated that grape seed proanthocyanidins appear to exert pharmacological effects. These include anti-oxidant, anti-microbial, anti-obesity, anti-diabetic, anti-neurodegenerative, anti-osteoarthritis ...Daha fazlası

Water level change of lakes and sinkholes in Central Turkey under anthropogenic effects

DEMİR, Vahdettin | ÜLKE KESKİN, Aslı

Determining water level changes in lakes is significant for sustainable water supply planning, flood control, water resource management, and economic development with ecosystem sustainability. Trend analysis is a commonly used tool for detecting changes in hydrologic time series of quantities such as lake level, precipitation and temperature. Trend analysis of meteorological variables is very important for assessing the long-term changes in lake levels. This study examines long-term changes in the lakes in the Central Anatolia region of Turkey. Kızören and Timraş sinkhole lakes and Lakes Tuz a ...Daha fazlası

The Effect of the Education Model on the Levels of State/Continuous Anxiety and Self‑Efficacy of Midwifery Students

Background: In midwifery practice, the education model used for skill acquisition is extremely important for the management of students’ stress, anxiety and self‑efficacy. Innovative practices aim to improve the students’ cognitive, emotional and psychomotor skills, and new research needs to be performed to evaluate the results of such practices. Aims: The present study aimed to evaluate the effects of the education model and clinical practice features, such as practice time, laboratory practice and exam evaluation, on the students’ state and continuous anxiety and self‑efficacy status. Method ...Daha fazlası

Correlation of neutrophil/lymphocyte and platelet/lymphocyte ratios with the severity of idiopathic carpal tunnel syndrome

GÜNEŞ, Muzaffer | BÜYÜKGÖL, Hüseyin

Background: The aim of the present study was to investigate the correlation of the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio with the severity of idiopathic carpal tunnel syndrome (CTS). Methods: A total of 407 patients with idiopathic CTS (neurophysiologically 150 mild, 144 moderate, and 113 severe) and 206 subjects without CTS were included (control group). Results: There was a positive correlation between the severity of CTS and NLR (r = 0.224; P < 0.001), age (r = 0.333; P < 0.001), and body mass index (r = 0.251; P < 0.001). A 1-unit increase in NLR level was associa ...Daha fazlası

Teachers’ self-efficacy is related to their nutrition teaching methods

ÜNÜSAN, Nurhan | YALÇIN, Hatice

Background: Teacher-led nutrition education is a practical method for informing children about healthy eating at an early age. Commonly reported teacher barriers include self-efficacy and use of teaching methods. Objective: This study is the first to evaluate preschool teachers’ self-efficacy in teaching nutrition and their preferred teaching methods. Material and Method: Researchers recruited preschool teachers from 133 preschools in Konya. At the baseline, teachers were asked to provide demographic information, including their age, sex, level of education, teaching experience, previous invol ...Daha fazlası

İki Linkli Robot Manipülatörün Modellenmesi ve Bozucu Etki Altında Yörünge Kontrolü

İLGEN, Sinan | DURDU, Akif | GÜLBAHÇE, Erdi | ÇAKAN, Abdullah

Bu çalışmada, iki linkli düzlemsel bir robot manipülatörün bozucu etki altında yörünge kontrolü yapılmıştır. ADAMS yazılımı vasıtasıyla manipülatörün sanal bir prototipi oluşturulmuştur. Ayrıca, sistem için gerekli olan kontrolcü tasarımı MATLAB/Simulink ortamında gerçekleştirilmiştir. Sistemin simülasyonu ise MATLAB ve ADAMS yazılımlarının eş zamanlı olarak çalıştırılması ile gerçekleştirilmiştir. Robot manipülatör iki giriş ve dört çıkışa sahiptir. Girişler, her iki eklemin tahriki için gerekli olan motor torkları, çıkışlar ise her iki eklemin açıları ve uç elemanın konumunun x-y bileşenleri ...Daha fazlası

Trend Analyses of Meteorological Variables and Lake Levels for Two Shallow Lakes in Central Turkey

YAĞBASAN, Özlem | DEMİR, Vahdettin | YAZICIGİL, Hasan

Trend analyses of meteorological variables play an important role in assessing the long-term changes in water levels for sustainable management of shallow lakes that are extremely vulnerable to climatic variations. Lake Mogan and Lake Eymir are shallow lakes offering aesthetic, recreational, and ecological resources. Trend analyses of monthly water levels and meteorological variables affecting lake levels were done by the Mann-Kendall (MK), Modified Mann-Kendall (MMK), Sen Trend (ST), and Linear trend (LT) methods. Trend analyses of monthly lake levels for both lakes revealed an increasing tre ...Daha fazlası

The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra | MENEVŞE, Esma | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The purpose of this study was to investigate the effects of zinc and melatonin administration on interleukin-6, lipid peroxidation parameters, and element metabolism in DMBA-induced breast cancer in female rats. A total of 42 recently weaned Wistar rats were divided into 5 groups as follows: control (group 1),DMBA control (group 2),DMBA + zinc (group 3), DMBA + melatonin (group 4), and DMBA + melatonin and zinc (group 5). Malondialdehyde (MDA) and glutathione (GSH) levels in breast tissue and blood samples were determined via spectrophotometric methods. In addition, iron, magnesium, zinc, and ...Daha fazlası

Survey on the User Satisfaction with the Mass Housing Projects Led by District Municipality: Konya-Karatay Example

HATİPOĞLU ŞAHİN, Betül | TERECİ, Ayşegül

Mass housing played an important role in changing the face of the cities. The Municipality Law No.5393 which gave the right to municipalities to build mass housing were factors that have accelerated the mass housing production. The main goal of local administrations is to build houses in the most rapid and economic way for group of people with low income. However, such production has posed problems in terms of quantity and quality. This research has been conducted to measure the satisfaction levels of users from mass housing projects which are implemented under the leadership of the municipali ...Daha fazlası