Objectives: In this study, it was aimed to evaluate the hypoxia-inducible factor-1α (HIF-1α) and ischemia-modified albumin (IMA) levels of patients diagnosed with COVID-19 in the intensive care unit (ICU) and healthy controls. To our knowledge, this is the first study investigate HIF-1α and IMA levels in COVID-19 patients in ICUs and comparing them with a healthy control group. For this reason, our study is original and will contribute to the literature. Methods: A total of 70 intensive care patients diagnosed with COVID-19, and 72 healthy controls were included in the study. Results: When we compared the patient and healthy control group; there were no statistically significant differences between the groups in terms of age and gender (p>0.05). No exitus was observed in the patient group. We found weak correlation between HIF-1α and IMA (r: 0.320). However, there were statistically significant differences in HIF-1α and IMA levels in the patient group. The receiver operating characteristic (ROC) curve demonstrated an area under curve (AUC) value of 0.651 for HIF-1α and 0.937 for IMA. Conclusions: The HIF-1α and IMA levels were significantly higher among COVID-19 patients in ICU compared with healthy controls. HIF-1α and IMA levels can be used as reliable markers for the prognosis of COVID-19.
Eser Adı (dc.title) | Hypoxia-inducible factor-1α and ischemiamodified albumin levels in intensive care COVID-19 Patients |
Yayın Türü (dc.type) | Makale |
Yazar/lar (dc.contributor.author) | YÜCEL, Kamile |
Yazar/lar (dc.contributor.author) | GÜRBÜZ, Ali Fuat |
Atıf Dizini (dc.source.database) | Wos |
Atıf Dizini (dc.source.database) | Scopus |
Konu Başlıkları (dc.subject) | COVID-19 |
Konu Başlıkları (dc.subject) | Hypoxia-Inducible Factor |
Konu Başlıkları (dc.subject) | Ischemiamodified Albumin |
Konu Başlıkları (dc.subject) | Receiver Operating Characteristic |
Yayıncı (dc.publisher) | De Gruyter |
Yayın Tarihi (dc.date.issued) | 2023 |
Kayıt Giriş Tarihi (dc.date.accessioned) | 2023-03-01T11:43:01Z |
Açık Erişim tarihi (dc.date.available) | 2023-03-01T11:43:01Z |
Özet (dc.description.abstract) | Objectives: In this study, it was aimed to evaluate the hypoxia-inducible factor-1α (HIF-1α) and ischemia-modified albumin (IMA) levels of patients diagnosed with COVID-19 in the intensive care unit (ICU) and healthy controls. To our knowledge, this is the first study investigate HIF-1α and IMA levels in COVID-19 patients in ICUs and comparing them with a healthy control group. For this reason, our study is original and will contribute to the literature. Methods: A total of 70 intensive care patients diagnosed with COVID-19, and 72 healthy controls were included in the study. Results: When we compared the patient and healthy control group; there were no statistically significant differences between the groups in terms of age and gender (p>0.05). No exitus was observed in the patient group. We found weak correlation between HIF-1α and IMA (r: 0.320). However, there were statistically significant differences in HIF-1α and IMA levels in the patient group. The receiver operating characteristic (ROC) curve demonstrated an area under curve (AUC) value of 0.651 for HIF-1α and 0.937 for IMA. Conclusions: The HIF-1α and IMA levels were significantly higher among COVID-19 patients in ICU compared with healthy controls. HIF-1α and IMA levels can be used as reliable markers for the prognosis of COVID-19. |
Yayın Dili (dc.language.iso) | en |
Tek Biçim Adres (dc.identifier.uri) | http://hdl.handle.net/20.500.12498/5920 |