Ratio of Serum Levels of AGEs to Soluble Form of RAGE Is a Predictor of Metabolic Syndrome

BABA, Burcu | KAYA, Turgut | BERBEROĞLU, Hatice Tuğçe | ÖZTÜRK, Bahadır | KIRAÇ, Cem Onur | HACIŞEVKİ, Aysun

Metabolic syndrome (MetS) is a common metabolic disorder that coexist diseases such as dyslipidemia, hypertension, hyperglycemia, and obesity, that increase the risk for developing type 2 diabetes and cardiovascular disease. RAGE (receptor for advanced glycation end-products) is a receptor of the immunoglobulin superfamily, has been implicated in diabetes and its complications, inflammation, and atherosclerosis. RAGE binds multi-ligands such as AGEs (advanced glycation end products) and S100 proteins and binding of ligands activates signaling pathways that involved in cellular stress responses ...Daha fazlası