Impact Of Preoperative Computed Tomography-Determined Quantity And Quality Of Skeletal Muscle On Survival After Resected Non-Small Cell Lung Carcinoma

ÇINAR, Hüseyin Ulaş | ÇELİK, Burçin | TAŞKIN, Gülten | İNCE, Özgür

Objective: This study investigated the prognostic effect of preoperative skeletal muscle quantity and quality on survival after Non-Small Cell Lung Cancer (NSCLC) resection. Methods: This retrospective study consisted of patients with NSCLC who underwent curative lung cancer resection between 2015 and 2020. Skeletal muscle quantity and quality, as determined by paravertebral muscle index (PVMI) and paravertebral muscle density (PVMD), were measured at the level of the twelfth thoracic vertebra on preoperative images of computed tomography. The patients were divided into two subgroups as low an ...Daha fazlası

Determination Of Cytokine Profile And Associated Genes Of The Signaling Pathway In Hnscc

KALAYCI YIGIN, Aysel | AZZAWRI, Ali | ÖZTÜRK, Kayhan | CORA, Tulin | SEVEN, Mehmet

Head and neck squamose cell carcinoma (HNSCC) is an aggressive group of tumors that are generally heterogeneous. Despite treatment advances, disease-free survival has not significantly improved. Therefore, it is of great importance to understand the molecular etiology of HNSCC and genetic alterations in the signal pathways in order to develop new therapeutic approaches. In this study, firstly we used a cytokine array to analyze the secretomes of HNSCC patients and healthy controls. In the next step, the results from the cytokine sequence were validated by qRT-PCR and western blot, including ge ...Daha fazlası

A Realistic View On The Essential Medicinal Chemistry Of Curcumin

BAHADORI, Fatemeh | DEMİRAY, Mutlu

The relationship between spiritual well-being and quality of life in cancer survivors

YILMAZ, Meryem | CENGİZ, Hatice Öner

Objective. To evaluate the relationship between spiritual well-being (SpWB) and quality of life (QoL) in cancer (CA) survivors. Methods. The current study was conducted in the oncology center at a university hospital in Central Anatolia/Turkey. In this study, a descriptive cross-sectional survey design was used. The data collected included: a questionnaire form, the current study was conducted in the oncology center at a university hospital in Central Anatolia/Turkey. In this study, a descriptive cross-sectional survey design was used. SpWB was assessed by the Functional Assessment of Chronic ...Daha fazlası

Male Gender Is A Risk Factor For High-Risk Colorectal Polyps

AVCI, Enver | AY, Serden

Aim: Almost all colorectal cancers originate from polyps. Polyps are divided into two groups: neoplastic and non-neoplastic. The most commonly detected polyps are adenomatous polyps, and some of them have a high risk of malignancy. In our study, we aimed to investigate the effect of age and gender on high risk colorectal polyps. Material and Methods: We retrospectively reviewed the colonoscopy procedures performed in our Endoscopy Unit between January 2018 and January 2022. Demographic information of patients and colonoscopy reports were re-examined from the hospital information system. Result ...Daha fazlası

Marginal Maternal Zinc Deficiency Produces Liver Damage And Altered Zinc Transporter Expression In Offspring Male Rats

GÜMÜŞ, Meltem | GÜLBAHÇE MUTLU, Elif | ÜNAL, Ömer | BALTACI, Saltuk Buğra | ÜNLÜKAL, Nejat | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The aim of this study was to investigate how zinc deficiency and supplementation affect liver markers including autotaxin, kallistatin, endocan, and zinc carrier proteins ZIP14 and ZnT9 in rats exposed to maternal zinc deficiency. Additionally, the study aimed to assess liver tissue damage through histological examination. A total of forty male pups were included in the research, with thirty originating from mothers who were given a zinc-deficient diet (Groups 1, 2, and 3), and the remaining ten born to mothers fed a standard diet (Group 4). Subsequently, Group 1 was subjected to a zinc-defici ...Daha fazlası

The Effect Of Progressive Muscle Relaxation Exercises On Sleep Quality In Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Study

SARI, Ebru | GÜNDOĞDU, Fatma | SEMERCİ, Remziye

Objectives: This study aimed to evaluate the effect of progressive muscle relaxation exercises (PMRE) on sleep quality in patients undergoing chemotherapy treatment and experiencing disturbed sleep. Methods: The prospective randomized controlled study was conducted between March and September 2022 with 69 patients (intervention group: 34 patients, control group: 35 patients) in a hospital chemotherapy unit. During the data collection process, the Personal Information Form and Pittsburgh Sleep Quality Index (PSQI) were utilized. Patients in the intervention group performed PMRE twice a day for ...Daha fazlası

Impacts Of Potential Anticancer Agents Based On Pillar[5]Arene For Head And Neck Squamous Cell Carcinoma Cells

KÜÇÇÜKTÜRK, Serkan | KARASELEK, Mehmet Ali | DURAN, Tuğçe | KURSÜNLÜ, Ahmed Nuri | ÖZMEN, Mustafa

PurposeThis study was conducted to investigate impacts of potential anticancer (associated with apoptosis and caspase pathways) of two newly synthesized derivatives of pillar[5]arene, named as d-Q-P5 and p-Q-P5, on Squamous cell carcinomas of the head and neck (HNSCC) cells.Materials and methodsThe MTT method was used to determine the IC50 doses of the derivatives on HNSCC cells, and the changes in gene expression were analyzed by real-time polymerase chain reaction (qPCR). The apoptosis change was confirmed by flow cytometry analysis.ResultsThe results showed that the d-Q-P5 and p-Q-P5 effect ...Daha fazlası

Kanser Tanısı Alan Birey Ve Ailesinde Ruh SağlığıMental Health Of The Diagnosed Patients Of Cancer And Their Families

KARAGİL,Fatma Merve Akkanat | HARMANCI, Hatice

Kanser, vücuttaki bazı hücrelerin farklı değişkenler sebebiyle kontrol dışında çoğalmasıyla oluşan ve genellikle anormal doku büyümesiyle kendini gösteren çok boyutlu bir hastalık olarak tanımlanmaktadır. Kanser hastalığının çok boyutlu olması, kanser tanısı alan bireylerin hastalıkla beraber birçok farklı sorun yaşamalarına neden olmaktadır. Bu sorunlar, hastalık süreci boyunca genel olarak fiziksel, sosyal, psikolojik ve ekonomik yönden hastaların birtakım zorluklar yaşamasıyla ortaya çıkmaktadır. Ayrıca tanı alan hastalara bakım sağlayan aile üyelerinin de bu süreç boyunca farklı sorunlar y ...Daha fazlası