The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats

The purpose of this study was to investigate the effects of zinc and melatonin administration on interleukin-6, lipid peroxidation parameters, and element metabolism in DMBA-induced breast cancer in female rats. A total of 42 recently weaned Wistar rats were divided into 5 groups as follows: control (group 1),DMBA control (group 2),DMBA + zinc (group 3), DMBA + melatonin (group 4), and DMBA + melatonin and zinc (group 5). Malondialdehyde (MDA) and glutathione (GSH) levels in breast tissue and blood samples were determined via spectrophotometric methods. In addition, iron, magnesium, zinc, and copper levels in serum samples were determined by atomic emission, and plasma interleukin-6 levels were determined by ELISA method. The highest tissue and plasmaMDA and the lowest tissue and erythrocyte GSH levels found in the study were in group 2; the highest tissue and erythrocyte GSH levels and the lowest tissue and plasma MDA levels are in group 5 (P < 0.05). Iron, magnesium, and zinc levels of groups 3, 4, and 5 were higher than the DMBA group without administration (group 2), but the copper values were significantly lower (P < 0.05). The highest IL-6 levels were determined in group 2 while IL-6 levels in the DMBA group (G5) treated with combined melatonin and zinc were lower than all other breast cancer groups (P < 0.05). According to the findings obtained in this presented study, combined zinc and melatonin therapy can contribute to the prevention of tumor growth by improving the disruption in element metabolism and suppressing IL-6 levels and reducing tissue damage that causes the cancer.

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Eser Adı
(dc.title)
The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats
Yayın Türü
(dc.type)
Makale
Yazar/lar
(dc.contributor.author)
GÜLBAHÇE MUTLU, Elif
Yazar/lar
(dc.contributor.author)
BALTACI, Saltuk Buğra
Yazar/lar
(dc.contributor.author)
MENEVŞE, Esma
Yazar/lar
(dc.contributor.author)
MOĞULKOÇ, Rasim
Yazar/lar
(dc.contributor.author)
BALTACI, Abdülkerim Kasım
Atıf Dizini
(dc.source.database)
Wos
Atıf Dizini
(dc.source.database)
Scopus
Konu Başlıkları
(dc.subject)
DMBA
Konu Başlıkları
(dc.subject)
Trace Element
Konu Başlıkları
(dc.subject)
IL-6
Konu Başlıkları
(dc.subject)
Rat
Konu Başlıkları
(dc.subject)
Lipid Peroxidation
Yayın Tarihi
(dc.date.issued)
2020
Kayıt Giriş Tarihi
(dc.date.accessioned)
2021-01-22T08:40:24Z
Açık Erişim tarihi
(dc.date.available)
2021-01-22T08:40:24Z
Özet
(dc.description.abstract)
The purpose of this study was to investigate the effects of zinc and melatonin administration on interleukin-6, lipid peroxidation parameters, and element metabolism in DMBA-induced breast cancer in female rats. A total of 42 recently weaned Wistar rats were divided into 5 groups as follows: control (group 1),DMBA control (group 2),DMBA + zinc (group 3), DMBA + melatonin (group 4), and DMBA + melatonin and zinc (group 5). Malondialdehyde (MDA) and glutathione (GSH) levels in breast tissue and blood samples were determined via spectrophotometric methods. In addition, iron, magnesium, zinc, and copper levels in serum samples were determined by atomic emission, and plasma interleukin-6 levels were determined by ELISA method. The highest tissue and plasmaMDA and the lowest tissue and erythrocyte GSH levels found in the study were in group 2; the highest tissue and erythrocyte GSH levels and the lowest tissue and plasma MDA levels are in group 5 (P < 0.05). Iron, magnesium, and zinc levels of groups 3, 4, and 5 were higher than the DMBA group without administration (group 2), but the copper values were significantly lower (P < 0.05). The highest IL-6 levels were determined in group 2 while IL-6 levels in the DMBA group (G5) treated with combined melatonin and zinc were lower than all other breast cancer groups (P < 0.05). According to the findings obtained in this presented study, combined zinc and melatonin therapy can contribute to the prevention of tumor growth by improving the disruption in element metabolism and suppressing IL-6 levels and reducing tissue damage that causes the cancer.
Yayın Dili
(dc.language.iso)
eng
Sponsor-Yayıncı
(dc.description.sponsorship)
Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK; project no. 16202035).
Tek Biçim Adres
(dc.identifier.uri)
http://hdl.handle.net/20.500.12498/4974
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