Effects of Soybean Seed (Glycine max) on Some Biochemical Parameters in Streptozotocin- Induced Daibetic Rats

GÜLBAHÇE MUTLU, Elif | ARSLAN, Emine | ARIKOĞLU, Hilal | ERKOÇ KAYA, Dudu

Introduction: Diabetes mellitus is the most widespread and increasingly global prevalence and incidence, and is a chronic metabolic disorder resulting from insulin deficiency or insulin insufficiency. A consequence of this is chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism. In this study, soybean (Glycine max L.) seed extract in wistar rats created experimentally diabetic was aimed to investigate of the effects to some biochemical parameters (Urea, Creatinine, AST, ALT, Cholesterol, Triglycerides, Glucose, LDL, HDL, VLDL) and hyperglycemia. Material and Met ...Daha fazlası

Cerebral Ischemia Reperfusion Injury in Rats: Effect of 3’,4’-Dihydroxyflavonol

MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım | MENEVŞE, Esma | BALTACI, Saltuk Buğra | GÜLBAHÇE MUTLU, Elif

The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on experimental brain ischemia-reperfusion in rats. The study was performed on the 34 male Wistar-albino rats, weigth 350-400 gr. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; 3-DiOHF+Ischemiareperfusion; 4-Ischemia+DiOHF+Reperfusion; 5- Ischemia-reperfusion+DiOHF. DiOHF was given to animals as 10 mg/kg by intraperitoneal. Cerebral cortex was analyzed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Tissue MDA level ...Daha fazlası

Bozkır Ağaç sincabının (Sciurus anomalus) diğer Sciurus türleri arasındaki Filogenetik akrabalığının belirlenmesi

GÜLBAHÇE MUTLU, Elif | ARSLAN, Emine | ARSLAN, Atilla

Kemiriciler (Rodentia) dünyadaki mevcut memeliler arasında en büyük grubu oluşturmaktadırlar ve kendi aralarında taksonomik ve filogenetik sınıflandırılması oldukça önemlidir. Sciurus cinsi, Rodentia takımı içerisinde yer alan Sciuridae (Sincapgiller) familyasının üyelerindendir. Türkiye’de Sciurus anomalus ve Sciurus vulgaris türleri yayılış göstermektedir. Bu çalışmada Konya ili Bozkır ilçesinden elde edilen S. anomalus türü ile Gen Bankası (NCBI)’ndan elde edilen Sciurus türleri arasında filogenetik akrabalıkların mitokondrial sitokrom b gen dizileri kullanılarak belirlenmesi amaçlanmıştır. ...Daha fazlası

The Cytotoxic Effects of Soybean (Glycine max L.) in Breast Cancer MCF-7 Cell Line In Vitro

KOYGUN, Gözde | ARSLAN, Emine | GÜLBAHÇE MUTLU, Elif

Aim of the study: Breast cancer is one of the most noticeable disease in women aged 20-59 years also it is expected to account for 30% of all new cancer diagnoses in women in 2016, Long-term use ofsoybean (Glycine max 1.) may prevent the progression of cancer. However, the molecular mechanism forthe functions of soybean remains unclear. So we decided to see how effective soybeans are on MCF-7Cell lines. Materials and Methods: Human breast cancer cell lines MCF-7 were treated with different concen-trations of methanol extract of soybean seeds. The growth rate was evaluated by XTT tests for 48 a ...Daha fazlası

Effect of Chronic Running Exercise in Experimental Diabetes Mellitus Rat Model on Lipid Peroxidation in the Hippocampus

YAŞLI, Mehmet | BALTACI, Saltuk Buğra | AKGÜN ÜNAL, Nilüfer | GÜLBAHÇE MUTLU, Elif | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

Introduction and Objectives: The aim of this study is to investigate the effect of the chronic running exercise in diabetic rats on lipid peroxidation in hippocampus tissue. The study was carried out in Experimental Medicine Research and Application Center of Selçuk University on adult male Wistar rats that were obtained from the same center. The study protocol was approved by the Ethics Committee of Experimental Animals of Experimental Medicine Research and Application Center of Selcuk University. Methods: A total of 40 rats were equally divided into 4 groups: Group 1, Control, Group 2, Exerc ...Daha fazlası

DMBA ile meme kanseri oluşturulmuş sıçanlarda artan uterus doku hasarı çinko ve melatonin desteğiyle önlenir*

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra

Amaç: Bu çalışmanın amacı dişi sıçanlarda DMBA ile oluşturulmuş meme kanserinde çinko ile melatonin uygulamasının uterus dokusundaki lipit peroksidasyonu üzerine olan etkilerinin araştırılmasıdır. Gereç ve Yöntem: Wistar cinsi sütten yeni kesilmiş toplam 42 adet dişi sıçan kullanılan araştırmada hayvanlar 5 gruba ayrıldı: Grup 1 Kontrol, Grup 2 DMBA Kontrol, Grup 3 DMBA+Çinko, Grup 4 DMBA+Melatonin, Grup 5 DMBA+Melatonin ve Çinko. Grup 1 dışındaki hayvanlara meme kanseri oluşturmak için kolza yağı (kanola) içinde 80 mg/kg dozunda DMBA gavaj yoluyla verildi. Çinko ve melatonin uygulanan gruplar ...Daha fazlası

Determination of relationship degrees according to protein profiles of some fish species living in Beyşehir, Suğla Lake and Dam Apa and investigation of the effect on protein profiles of seasonal temperature changes in some fish species

ARSLAN, Emine | GÜLBAHÇE MUTLU, Elif

Comparisons based on morphological characters is not enough for making the right decision in the determination of the species of taxonomists. Electrophoretic methods are frequently used by animal systematics in taxonomic studies. Proteins are the product of gene effect and are used as genetic markers that play an important role in determining the taxonomic status. In recent years, electrophoretic investigation of proteins has contributed both to the systematic studies and to the studies done on the biochemistry of fish. As well as determining degrees of relationship among fish that are collect ...Daha fazlası

The Effect of the Application of Melatonin and Zinc in DMBA-Induced Mammary Carcinoma in Rats on Lipid Peroxidation and Element Metabolism

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra | MENEVŞE, Esma | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

In this study, it was aimed to investigate the effects of application of melatonin and zinc on lipid peroxidation and elemental metabolism in female rats with DMBA-induced mammary carcinoma. The study groups were composed of control, DMBA control and treatment (DMBA+ zinc, DMBA + melatonin and DMBA + zinc+melatonin) groups. Female rats (except the control group) were given a strong carcinogen DMBA. After tumour formation, zinc and melatonin were administered to the treatment groups at a dose of 5 mg/kg/day for 4 weeks. MDA as an indicator of tissue damage and GSH levels as an indicator of anti ...Daha fazlası

Kronik Yüzme Egzersizi Yaptırılan ve Grape Uygulanmış Epileptik Sıçanların Beyin Dokusundaki Element Dağılımı

AĞAR, Erdal | TUTKUN, Erkut | GÜLBAHÇE MUTLU, Elif | AYYILDIZ, Mustafa | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The Effect on β-Catenin Gene Expression of Grape Seed Extract in Experimental Diabetic Rats

GÜLBAHÇE MUTLU, Elif | ARSLAN, Emine | ARIKOĞLU, Hilal

Aim of the study: Diabetes Mellitus (DM) a chronic metabolic disease which occured as a result of deterioration in the signaling pathways of insulin in the target tissues. And, this case continued throughout the patient's life and reduced quality of life. WNT pathway is involved in lipid metabolism and glucose homeostasis, and β-catenin is located in this patway. In this study, we aimed to investigate the effects of grape seed (Vitis vinifera L.) extracts on β-catenin gene expression in wistar rats created experimental diabetic. Material and Methods: Rats were divided into five groups; healthy ...Daha fazlası

DNA Protective Effect of Mespilus Germanica (L).

ARSLAN, Emine | GÜLBAHÇE MUTLU, Elif | ARSLAN, Nursena

Increased IL-6 Levels Inhibites by Zinc and Melatonin Support in Rats with Breast Cancer induced by DMBA

BALTACI, Saltuk Buğra | GÜLBAHÇE MUTLU, Elif | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The aim of the present study determines the effect of zinc and melatonin supplementation on IL-6 levels in female rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). Total 42 wistar female rats which was just weaned from milk equally separated 5 groups. Group 1 control, Group 2 DMBA control, Group 3 DMBA+Zinc, Group 4 DMBA+Melatonin, Group 5 DMBA+Zinc+Melatonin. To induce breast cancer, the animals, except those in group 1, were administered 80 mg/kg of DMBA in colza oil (canola) through gavage. The groups which were supplemented with zinc and melatonin were introperitone ...Daha fazlası