A Case Report of Glanzman Thrombasthenia with Anterior Mediastinal Hematoma and Factor V Leiden Mutation

TOKGÖZ, Hüseyin | ÇALIŞKAN, Ümran | DURAN, Tuğçe | ÇALIŞKAN SAK, Kaniye Zeynep

Glanzmann thrombasthenia (GT) is an autosomal recessive disease associated with platelet aggregation dysfunction with normal platelet count, causing bleeding diathesis. GT is characterized by decreased levels or decreased function of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex and therefore results in an increased tendency to bleeding as the aggregation phase of primary hemostasis cannot be sufficiently formed. Factor V Leiden mutation is a genetic mutation predisposing to thrombophilia. We present this case in which Factor V Leiden mutation and Glanzmann thrombasthenia with hematoma in the ...Daha fazlası