Can we predict patients that will not benefit from invasive mechanical ventilation? A novel scoring system in intensive care: The imv mortality prediction score (IMPRES)

ÖZLÜ, Tevfik | PEHLİVANLAR KÜÇÜK, Mehtap | KAYA, Akın | YARAR, Esra | KIRAKLI, Sami Cenk | ŞENGÖREN DİKİŞ, Özlem | KEFELİ ÇELİK, Hale | ÖZKAN, Serdar | BEKTAŞ AKSOY, Hayriye | KÜÇÜK, Ahmet Oğuzhan

Background/aim: The present study aimed to define the clinical and laboratory criteria for predicting patients that will not benefit from invasive mechanical ventilation (IMV) treatment and determine the prediction of mortality and prognosis of these critical ill patients. Materials and methods: The study was designed as an observational, multicenter, prospective, and cross-sectional clinical study. It was conducted by 75 researchers at 41 centers in intensive care units (ICUs) located in various geographical areas of Turkey. It included a total of 1463 ICU patients who were receiving invasive ...Daha fazlası

Investigation of Respiratory Tract Pathogen Human Parechoviruses in Konya, Turkey

TOKAK, Semih | ÖZDEMİR, Mehmet | ESENKAYA TAŞBENT, Fatma

Objective This study aims to better understand the epidemiological characteristics of parechoviruses and to determine the genotype distribution in Konya, Turkey. Methods In this study, nasal and throat swab samples taken from 1,110 children who were diagnosed with respiratory tract infection (bronchitis, pneumonia, asthmatic bronchitis, and other respiratory diseases) and applied to various pediatric polyclinics of Meram Medical Faculty Hospital, Necmettin Erbakan University between September 2017 and March 2019 were evaluated. Human parechovirus (HPeV) RNA was investigated by multiplex polyme ...Daha fazlası

Solunum Yolu Enfeksiyonlu Çocuklarda Saptanan Viral Etkenlerin Epidemiyolojisi ve Mevsim Dağılımının Belirlenmesi

TOKAK, Semih | GÜLSEREN, Yasemin Derya | ÖZDEMİR, Mehmet

Giriş: Bu çalışmada hastanemizin çeşitli klinik ve polikliniklerine başvuran çocuk hastaların solunum yolu enfeksiyonlarında viral patojenlerin saptanması ve mevsimsel dağılımının araştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmaya, Ocak 2016-Ocak 2017 tarihleri arasında, üst veya alt solunum yolu enfeksiyonu ön tanısı alan, belirtileri ile hastaneye başvuran 997 çocuk (%45.1 kadın, %54.9 erkek, yaş aralığı 0 ay-17 yaş) dahil edildi. Hastalardan alınan örneklerden 21 viral solunum patojeni, Fast Track FTD Respiratory pathogens 21 (Fast Track Diagnosis Luxemburg) kiti kullanılarak mul ...Daha fazlası

Super Grandma, Active and Productive Women at 84 Years Operating in The Physiological Conditions of The Systems

SUNAR, Füsun | KOÇER, Bulent | ŞİMŞEK, Lütfi | ÇALIŞKAN, Kaniye Zeynep

Gebelerdeki Asemptomatik Bakteriüri: Sıklığı, Antimikrobiyal Duyarlılık Profili, Etken Mikroorganizmalar ve Risk Faktörleri

TOKAK, Semih | ERİÇ HORASANLI, Jule

Asemptomatik bakteriüri (ASB) idrar yolu infeksiyonlarının belirgin belirtileri olmadan idrarda bakteri varlığı olarak tanımlanmaktadır. Asemptomatik bakteriüri hamilelik sırasında ortaya çıkmakta olup hamilelik sırasında tedavi edilmediğinde olumsuz maternal ve perinatal sonuçlarla ilişkilendirilmektedir. Bu çalışmadaki amacımız bölgemizde kadın hastalıkları ve doğum kliniğine başvuran gebelerdeki ASB görülme sıklığını, ilişkili risk faktörlerini, bakteriüriye sebep olan mikroorganizmaları ve antibiyotik duyarlılıklarını belirlemektir. Üniversite hastanemizin kadın hastalıkları ve doğum klini ...Daha fazlası

Asymptomatic dermatophyte scalp carriage in school children in Erzincan, Turkey

AYDIN, Merve | GÜLHAN, Barış | GÜMRAL, Ramazan | İLKİT, Macit | ÖZTÜRK, Ali

Background: This study aimed to investigate the prevalence of symptomatic tinea capitis infections of the scalp and its asymptomatic carriage in students attending primary schools in Erzincan, Turkey. Materials and Methods: Eighteen primary schools were visited; 1 located in the central district and 17 located in other districts of the Erzincan province. From 2015 November to 2016 April, scalp scrapings were obtained from a total of 1879 students aged 6 to 13 years (mean age: 9.37±1.69) 924 (49.2%) male and 955 (50.8%) female using sterile hairbrushes, and assessed for tinea capitis and asympt ...Daha fazlası

Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients

KARAKEÇİLİ, Faruk | ÇIKMAN, Aytekin | AYDIN, Merve | GÜLHAN, Barış

BACKGROUND: High asymmetrical dimethylarginine (ADMA) levels have been associated with endothelial dysfunction and contribute to the development of several diseases. However, data on the relationship between hepatitis B virus (HBV) and ADMA are limited. The aim of our study was to explore the relationship between ADMA and HBV by comparing the ADMA levels in patients with chronic active hepatitis B (CHB), inactive HBV carriers (carriers), and healthy volunteers (controls). METHODS: The participants were divided into three groups: 90 patients with CHB, 90 HBV carriers, and 90 controls. Serum ADM ...Daha fazlası

In vitro anti-candidal and anti-biofilm activity of new ethane sulfonyl hydrazone compound

ÖZTÜRK, Ali | AYDIN, Merve | ÖZDEMİR ÖZMEN, Ümmühan

Candida species cause cutaneous and systemic infections with a high mortality rate, especially in immunocompromised patients. However, the emergence of resistance to the most common antifungal drugs, also due to biofilm formation, there is an increasing need to design new and more effective antifungals with less toxic. Sulfonyl hydrazones are well-known for their pharmacological effects, such as antifungal and antibacterial potential and can act as an antinociceptive, antidepressant, antineoplastic activity. The aim of this study was to investigate the anti-candidal and anti-biofilm activity o ...Daha fazlası

Erişkin Yoğun Bakım Ünitesinde Yatan Hastalarda Kandidemi Risk Faktörlerinin Belirlenmesi

TOKAK, Semih | UĞURCAN, Doğaç | TEKİNDAL, Mustafa Agah

Sağlık hizmeti ile ilişkili infeksiyonlar içinde önemli bir grubu mantar infeksiyonları oluşturmaktadır. Mantar infeksiyonları arasında en sık olarak Candida türleri izole edilmektedir. Candida türleri Amerika Birleşik Devletleri’nde dördüncü sırada yer alan hastane kaynaklı infeksiyon etkenidir. Bu çalışma ile yetişkin hastalardaki kandidemi risk faktörleri, Candida tür dağılımı ve antifungal duyarlılıklarının belirlenmesi amaçlanmıştır. Bu olgu-kontrol çalışmasında Ocak 2016-Ocak 2017 tarihleri arasında elde edilen veriler retrospektif olarak değerlendirildi. Hastalara ait demografik özellik ...Daha fazlası

In vitro antifungal and antibiofilm activities of new butane sulfonyl hydrazone compound against medically important yeast

AYDIN TERZİOĞLU, Merve | ÖZTÜRK, Ali | ÖZDEMİR ÖZMEN, Ümmühan

The prevalence of fungal infections has increased in the last two decades in parallel with the increasing number of immunosuppressed patients. The excessive use of antifungal agents is causing the accumulation of multi-resistance phenotypes in many fungal strains. Consequently, new alternative agents to conventional antifungal agents are urgently needed to prevent the emergence of fungal resistance. Sulfonyl hydrazone derived from sulfonamide, are well-known for their pharmacological effects, such as antifungal, antibacterial potential, and antineoplastic activity. This study aimed to investig ...Daha fazlası

Examining The Antitumoral Effect of Cornelian Cherry (Cornus Mas) in Ehrlich Ascites Tumor-Induced Mice

YILMAZ, Seher | ALPA, Şerife | NİSARİ, Mehtap | ŞEKER KARATOPRAK, Gökçe | ÜLGER, Harun | ERTEKİN, Tolga

Introduction: Different doses of C. Mas concentrated syrup on ascitic tumors was investigated in the Ehrlich Ascites Tumor model (EAT). Material and Methods: A total of 46 Balb/C mice were used in our study, 6 of which were stock animals and the other were in ascitic tumor groups. EAT cells (1x106 EAT cells) were injected intraperitoneally into all of the mice. Mice in the treatment groups with ascitic tumors received 100 mg/kg and 200 mg/kg Cornus Mas extract intraperitoneally for 9 days. Results: Counts after the 3 and 24-hour incubations in the EAT cell line that the average number of the d ...Daha fazlası

Could interleukin-33 and its suppressor of tumorigenicity 2 (ST2) receptor have a role in cervical human papillomavirus (HPV) infections?

KULHAN, Nur Gözde | KULHAN, Mehmet | AYDIN, Merve | NAYKİ, Ümit | NAYKİ, Cenk | ULUĞ, Paşa | ATA, Nahit | MERTOĞLU, Cuma | ÇIKMAN, Aytekin | SAYAR, İlyas | TÜRKLER, Can

Why most women can clear human papillomavirus (HPV) infections while others can develop permanent infections. The stimulation of immunotolerance of the immune system of the host by the persistent HPV infection may be the answer to this question. Interleukin-33 (IL-33) may play a role in the pathogenesis of HPV infection, this hypothesis was thought to be due to the rapid release of IL-33 from damaged cells following tissue damage, necrosis, and activation of the inflammasome. Thus, in this study, the role of IL33/suppressor of tumorigenicity 2 (ST2) was emphasized in HPV positive and HPV negat ...Daha fazlası