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Bulunan: 8 Adet 0.000 sn
- Eklemek veya çıkarmak istediğiniz kriterleriniz için 'Dahil' / 'Hariç' seçeneğini kullanabilirsiniz. Sorgu satırları birbirine 'VE' bağlacı ile bağlıdır.
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Filtreler
Filtreler
Bulunan: 8 Adet 0.000 sn
Yazar/lar : GÜLBAHÇE MUTLU, Elif ... ✕
Koleksiyon [2]
İlgili Araştırmacılar [6]
Ambargo Durumu [1]
Tam Metin [1]
Yayın Türü [2]
Yazar/lar [12]
Atıf Dizini [4]
Konu Başlıkları [20]
Yayıncı [4]
Dergi Adı [2]
Yayın Tarihi [2]
Dergi Sayısı [1]
Yayın Dili [2]
dc.description.provenance [8]
Erişime Açık

In Vitro Activity of Coenzymeq10 Loaded Mesoporous Silica Nanoparticles Against Mcf-7 Cells

GÜLBAHÇE MUTLU, Elif | ŞEFLEK, Hatice Nur | ALPA, Şerife | ERTUŞ, Emre Burak | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur

Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası

Konferans Bildirisi 2023 İKİNCİ ULUSLARARASI SELÇUK SAĞLIK BİLİMLERİ KONGRESİ 1 Görüntülenme
Erişime Açık

Determination of Cytoxic Effects of Diazepam and Flumazenil in MCF-7 Cell Line

TÜRKOĞLU, Fatma Nur | ALPA, Şerife | GÜLBAHÇE MUTLU, Elif | ERBAYRAM, Fatma Zehra | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, the second most common cause of cancer death, is a global public health problem due to its poor response to treatment and complex aetiology. The MCF-7 cell line is widely used in laboratories around the world for in vitro studies to address this problem. Diazepam is one of the most successful anaesthetics since the beginning of the psychopharmacological revolution. It belongs to a class of benzodiazepines that is often preferred in anaesthesia. Flumazenil is an imidazobenzodiazepine and was the first benzodiazepine antagonist to enter clinical use. The e ...Daha fazlası

Konferans Bildirisi 2023 Selçuk Üniversitesi 2 Görüntülenme
Erişime Açık

Determination Of Cytoxic Effects Of Oxytocin And Atosiban Mcf-7 Cell Line

ERBAYRAM, Fatma Zehra | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | TÜRKOĞLU, Fatma Nur | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, a major cause of cancer-related deaths, is an important health problem due to its inadequate response to treatment and complex etiology. Oxytocin (OT) is a peptide mammalian hormone consisting of nine amino acids. Today, cellular studies of oxytocin have gained importance. Oxytocin has been observed to inhibit cell proliferation in cancer. The biggest advantage of oxytocin therapies is that they provide the organism with cell production on its own and have no side effects. Studies have shown that OT is a factor that stimulates cell proliferation in lung, ...Daha fazlası

Konferans Bildirisi 2023 Selçuk Üniversitesi 0 Görüntülenme
Erişime Açık

Determination of The Cytotoxic Effect of Propylthiouracil Loaded Mesoporous Silica on Mcf-7 Cell Line

GÜLBAHÇE MUTLU, Elif | ŞEFLEK, Hatice Nur | ALPA, Şerife | ERTUŞ, Emre Burak | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur

Background of the Study: Nanomedicine is being investigated nanotechnology-based solutions to medical problems to increase the bioavailability of drugs and reduce side effects. The ultimate goal is to enable more effective and patient-friendly treatment regimens by reducing drug concentration and dosing frequency, offering easier administration and improving safety. Silica-based nanoparticles are widely used in nanomedicine and are emerging as a promising next-generation material for biological applications. Mesoporous silica nanoparticles (MSNs) have been used as drug nanocarriers in breast c ...Daha fazlası

Konferans Bildirisi 2023 SELÇUK ÜNİVERSİTESİ 0 Görüntülenme
Erişime Açık

The Effect Of Coenzyme Q10 Administration On The Expression Of Some Genes In Rats With Hypothroidia

ŞEFLEK, Hatice Nur | GÜLBAHÇE MUTLU, Elif | CÜCE, Gökhan | KALKAN, Serpil

Introduction: Hypothyroidism is an endocrine disorder that occurs mainly due to the insufficiency of thyroid hormones in the body or the inability of these hormones to affect target tissues. As a result of the insufficiency of thyroid hormones, the systems are affected and accordingly, the health status of individuals is adversely affected. Coenzyme Q10 is a lipophilic antioxidant that plays a role in membrane stability, energy conversion and ATP production. The aim of this study was to determine the effect of Coenzyme Q10 on GDNF, PLZF, SOX3 and THY1 gene expression levels in rats with hypoth ...Daha fazlası

Konferans Bildirisi 2023 SELÇUK ÜNİVERSİTESİ 0 Görüntülenme
Erişime Açık

Determination of Antioxidant and Anticancer Activities of C. Sativa Leaf Extracts on MCF7 Human Breast Cancer Cell Line

BEYAZYÜZ, Fadime | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur | KULAÇ, Şemsettin

Aim: In this study, it was aimed to determine the total phenolic content, flavonoid content, and antioxidant activity of Castanea sativa Mill. (chestnut) leaf extract and their anti-proliferative effect on MCF 7 cell line. Materials and Methods: It determined antioxidant capacities by using DPPH assay, total phenolic content by using Folin-Ciocaltaeu method and Total flavonoid content by aluminum chloride colorimetric method in the ethanolic extracts of Chesnut leaf. In addition, the anti-proliferative effect of chestnut leaf extract was determined by XTT method in MCF7 breast cell line. The l ...Daha fazlası

Makale 2023 Medical Records5 0 Görüntülenme
Erişime Açık

Determination of Antioxidant and Anticancer Activities of C. sativa Leaf Extracts on MCF7 Human Breast Cancer Cell Line

BEYAZYÜZ, Fadiem | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur | KULAÇ, Şemsettin

Aim: In this study, it was aimed to determine the total phenolic content, flavonoid content, and antioxidant activity of Castanea sativa Mill. (chestnut) leaf extract and their anti-proliferative effect on MCF 7 cell line. Materials and Methods: It determined antioxidant capacities by using DPPH assay, total phenolic content by using Folin-Ciocaltaeu method and Total flavonoid content by aluminum chloride colorimetric method in the ethanolic extracts of Chesnut leaf. In addition, the anti-proliferative effect of chestnut leaf extract was determined by XTT method in MCF7 breast cell line. The l ...Daha fazlası

Makale 2023 Medical Records - International Medical Journal 5 Görüntülenme
Erişime Açık

Determination Of Cytotoxic Effect Of Castanea Sativa Mill Loaded Nanoporous Glass On The MCF-7 Cell Line

GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | ERTUŞ, Emre Burak | ERBAYRAM, Fatma Zehra | TÜRKOĞLU, Fatma Nur | BEYAZYÜZ, Fadime | KULAÇ, Şemsettin

Background: Nanoporous glasses (NGC) are amorphous materials with high surface area and high pore volume produced by selective leaching of phase separated alkaliborisilicate glasses in acidic solution. It also has a high SiO2 content and stands out as a promising new generation material in biological applications. Cestanea sativa (Mill) used in this study has valuable nutrients and is considered an important plant in many countries including Turkey. Matherials and Methods: In our study, the loading capacity of C. sativa (Mill) ethanolic extract loaded into NGC and the cytotoxic effect of C. sa ...Daha fazlası

Konferans Bildirisi 2022 1ST INTERNATIONAL CONGRESS of SELÇUK HEALTH SCIENCES 5 Görüntülenme
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