The Effects Of Resveratrol And Melatonin On Biochemical And Molecular Parameters İn Diabetic Old Female Rat Hearts

AKGÜN-ÜNAL, Nilufer | ÖZYILDIIRM, Serhan | ÜNAL, Ömer | GÜLBAHEÇE-MUTLU, Elif | MOĞULKOÇ, Rasim | BALTACI, Abdülkerim Kasım

The roles of melatonin and resveratrol-enhanced activation of SIRT1 (silent information regulator 1), GLUT4 (glucose transporter type 4), and PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) in mediating the protective effects on the heart in aged female rats with streptozotocin-induced diabetes were investigated. 16-month-old 48 Wistar female rats were separated into 8 groups with equal numbers. Group 1: Control, Group 2: Resveratrol Control, Group 3: Melatonin Control, Group 4: Resveratrol and Melatonin Control, Group 5: Diabetes, Group 6: Diabetes Resveratrol, G ...Daha fazlası