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The Effect of Zinc and Melatonin Supplementation on Lipid Peroxidation of Various Tissues of Rats with by DMBA-Induced Breast Cancer

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra

The purpose of this study was to investigate the effects of zinc and melatonin administration on lipid peroxidation in various tissues in DMBA-induced breast cancer in female rats. A total of 42 recently weaned Wistar rats were divided into 5 groups in the study: Group 1 (Control), Group 2 (DMBA Control), Group 3 (DMBA+Zinc), Group 4 (DMBA+Melatonin), Group 5 (DMBA+Melatonin, and Zinc). MDA (malondialdehyde) and GSH (glutathione) levels were determined via the spectrophotometric method in the lung, liver, spleen, pancreas, and kidney tissue samples taken from experimental animals. The highest ...Daha fazlası

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Zinc And Melatonin Supplementation Ameliorates Brain Cortex Tissue Damage in Dmba-Induced Breast Cancer İn Rats

GÜLBAHÇE MUTLU, Elif | BALTACI, Saltuk Buğra

BACKGROUND: This study aims to investigate the effects of zinc and melatonin supplementation on lipid peroxidation in the brain cortex in DMBA-induced breast cancer in female rats. METHODS: A total of 42 recently weaned Wistar rats were divided into 5 groups as follows: Control (Group 1), DMBA Control (Group 2), DMBA+Zinc (Group 3), DMBA+Melatonin (Group 4), DMBA+Melatonin & Zinc (Group 5). At the end of the study, all animals were sacrifi ced by decapitation and Malondialdehyde (MDA) and glutathione (GSH) levels in brain cortex tissue samples were determined via spectrophotometric methods. RE ...Daha fazlası

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Determination Of Cytoxic Effects Of Oxytocin And Atosiban Mcf-7 Cell Line

ERBAYRAM, Fatma Zehra | GÜLBAHÇE MUTLU, Elif | ALPA, Şerife | TÜRKOĞLU, Fatma Nur | ŞEFLEK, Hatice Nur

Background of the Study: Breast cancer, a major cause of cancer-related deaths, is an important health problem due to its inadequate response to treatment and complex etiology. Oxytocin (OT) is a peptide mammalian hormone consisting of nine amino acids. Today, cellular studies of oxytocin have gained importance. Oxytocin has been observed to inhibit cell proliferation in cancer. The biggest advantage of oxytocin therapies is that they provide the organism with cell production on its own and have no side effects. Studies have shown that OT is a factor that stimulates cell proliferation in lung, ...Daha fazlası

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