Effect of 3’-4’-dihydroxyflavonol on lipid per oxidation inexperimental renal ischemia-reperfusion in rats

KOÇ, Aynur | ERGENE, Neyhan | BALTACI, Abdülkerim Kasım | MOĞULKOÇ, Rasim

This study aimed to examine the affects of 3’-4’-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental renal ischemia-reperfusion. The research was conducted on Wistar-albino type male rat. The experimental groups were formed as 1.Control; 2.Sham; 3.Ischemia; 4.Ischemia+reperfusion; 5.DiOHF+Ischemia; 6.Ischemia+ DiOHF + reperfusion. The highest tissue glutathione levels were found in groups 5 and 6. Groups 1 and 2, which were control and sham groups respectively, had the lowest tissue GSH values. Ischemia group was found to have the highest tissue malondialdehyde (MDA) level. Tissue ...Daha fazlası

Relationship between generalized epileptic seizure and neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and neutrophil mediated inflammation.

GÜNEŞ, Muzaffer | BÜYÜKGÖL, Hüseyin

Aim: There is a close relationship between systemic inflammation and epileptic seizure. Recently, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) have been defined as significant inflammation biomarkers. In the present study, it was aimed to determine levels of NLR, PLR, and mean platelet volume (MPV) during generalized tonic clonic epileptic seizures, and to investigate their relationships with epileptic seizures.Methods: The present study was conducted on 72 patients with epilepsy who applied with primary and secondary generalized tonic clonic epileptic seizures accordi ...Daha fazlası

A retrospective analysis of 2713 hospitalized burn patients in a burns center in Turkey

ALBAYRAK, Yavuz | TEMİZ, Ayetullah | ALBAYRAK, Ayşe | PEKSÖZ, Rıfat | ALBAYRAK, Fatih | TANRIKULU, Yusuf

BACKGROUND: Burn trauma is a significant health problem that has physical, psychological, and economic repercussions on affected patients. The aim of this study was to present epidemiological and demographic characteristics of patients treated over an 8-year period at a reference burn treatment center located in the northeast of Turkey and serving a population of approximately four million people. METHODS: Each patient’s medical record was reviewed, and demographic features, source of burns, place of residence, total body surface area (TBSA), surgical treatment, duration of hospital stay, and ...Daha fazlası

Can we predict patients that will not benefit from invasive mechanical ventilation? A novel scoring system in intensive care: The imv mortality prediction score (IMPRES)

ÖZLÜ, Tevfik | PEHLİVANLAR KÜÇÜK, Mehtap | KAYA, Akın | YARAR, Esra | KIRAKLI, Sami Cenk | ŞENGÖREN DİKİŞ, Özlem | KEFELİ ÇELİK, Hale | ÖZKAN, Serdar | BEKTAŞ AKSOY, Hayriye | KÜÇÜK, Ahmet Oğuzhan

Background/aim: The present study aimed to define the clinical and laboratory criteria for predicting patients that will not benefit from invasive mechanical ventilation (IMV) treatment and determine the prediction of mortality and prognosis of these critical ill patients. Materials and methods: The study was designed as an observational, multicenter, prospective, and cross-sectional clinical study. It was conducted by 75 researchers at 41 centers in intensive care units (ICUs) located in various geographical areas of Turkey. It included a total of 1463 ICU patients who were receiving invasive ...Daha fazlası

Investigation of Respiratory Tract Pathogen Human Parechoviruses in Konya, Turkey

TOKAK, Semih | ÖZDEMİR, Mehmet | ESENKAYA TAŞBENT, Fatma

Objective This study aims to better understand the epidemiological characteristics of parechoviruses and to determine the genotype distribution in Konya, Turkey. Methods In this study, nasal and throat swab samples taken from 1,110 children who were diagnosed with respiratory tract infection (bronchitis, pneumonia, asthmatic bronchitis, and other respiratory diseases) and applied to various pediatric polyclinics of Meram Medical Faculty Hospital, Necmettin Erbakan University between September 2017 and March 2019 were evaluated. Human parechovirus (HPeV) RNA was investigated by multiplex polyme ...Daha fazlası

Randomized prospective comparison of long-term results of onlay and sublay mesh repair techniques for incisional hernia

SEVİNÇ, Barış | OKUŞ, Ahmet | AY, Serden | AKSOY, Nergis | KARAHAN, Ömer

Objective: Incisional hernia is a significant problem after laparotomy, and there is still no consensus on an ideal treatment method. The aim of this study was to compare the results of onlay and sublay mesh repair techniques. Material and Methods: In this randomized prospective trial, 100 patients were divided into two groups: Onlay and sublay groups. Recurrences were evaluated by performing a physical examination. Results: The median follow-up was 37.1 (26.6 to 46.5) months. In the onlay group, the mean operation time was significantly shorter. However, in terms of postoperative pain and wou ...Daha fazlası

A Realistic View on

BAHADORI, Fatemeh | DEMİRAY, Mutlu

The review paper entitled “The Essential Medicinal Chemistry of Curcumin”, published in the Journal of Medicinal Chemistry, by Nelson et al. (1) is a well-designed paper, presenting a new (and negative) approach to the well-known biologically active compound; curcumin. Although some arguments throughout this paper are completely true, the approach of the authors is unfortunately far from impartial, and many of the conclusions the authors draw from some of their referred papers are especially hard to accept.

Effects of curcumin on methyl methanesulfonate damage to mouse kidney

CÜCE, Gökhan | ÇETİNKAYA, Seda | İŞİTEZ, Nilay | KÜÇÇÜKTÜRK, Serkan | SÖZEN, Mehmet Enes | DEMİREL, Hasan Hüseyin | KALKAN, Sinan | CİĞERCİ, İbrahim Hakkı

Methylmethane sulfonate (MMS) is an alkylating agent that may react with DNA and damage it. We investigated histological changes and apoptosis caused by MMS and the effects of curcumin on MMS treated mouse kidneys. Twenty-four mice were divided into four equal groups: controls injected with saline, a group injected with 40 mg/kg MMS, a group injected with 40 mg/kg MMS and given 100 mg/kg curcumin by gavage, and a group given 100 mg/kg curcumin by gavage. MMS caused congestion and vacuole formation, and elevated the apoptotic index significantly, but had no other effect on kidney tissue. Curcum ...Daha fazlası

Adım Adım Anatomi

BABACAN, SERDAR | ÖZBAĞ, Davut | GÜLER, Mehmet Akif | ÖZTEKİN, Hüseyin Cahit | YILDIZ, Ziya | KELEŞ, Ali | GÜNGÖRER, Şule | ALPA, Şerife | ÖĞÜT, Eren | AYDIN KABAKÇI, Anıl Didem | TÜRKOĞLU, Fatma Nur | YILMAZ, Seher | TOKPINAR, Adem | ÖZDEMİR, Fikri | CANDAN, Büşra | ÇINAROĞLU, Selim | GÖLPINAR, Murat | ÖZKAN, Mazhar | KESKİNÖZ, Elif Nedret | ŞENOL, Deniz

Anatomi, tüm sağlık alanlarının temel taşı niteliğindedir. Tüm sağlık alanı ile ilgili eğitimlerde anatomi iyi öğretilmesi ve öğrenilmesi gereken bir derstir. Ülkemizde Tıp Fakültelerinden, Sağlık Bilimleri Fakülteleri ile Sağlık Meslek Yükseokulları’na kadar birçok okulda ders olarak okutulmaktadır. Anatomi dersi, ancak ve ancak görsel içeriğin zengin olduğu anlatımlarla olduğunda işlevselliği yüksektir. Bu amaçla görsel açıdan zengin resimlerle desteklenmiş, sistematik olarak adım adım Anatomi’yi öğretmeyi hedefleyen bu kitap hazırlanmıştır. Bu kitap, Tıp Fakülteleri, Diş Hekimliği Fakültele ...Daha fazlası

Investigating the anti-tumoral effect of curcumin on the mice inwhich Ehrlich ascites and solid tumor is created

YILMAZ, Seher | ÜLGER, Harun | ERTEKİN, Tolga | YAY, Arzu Hanım | NİSARİ, Mehtap | ALPA, Şerife | ACER, Niyazi

Volume estimation of the subcortical structuresin Parkinson’s disease using magnetic resonanceimaging: A methodological study

ERTEKİN, Tolga | ACER, Niyazi | İÇER, Semra | ALPA, Şerife

In vitro anti-candidal and anti-biofilm activity of new ethane sulfonyl hydrazone compound

ÖZTÜRK, Ali | AYDIN, Merve | ÖZDEMİR ÖZMEN, Ümmühan

Candida species cause cutaneous and systemic infections with a high mortality rate, especially in immunocompromised patients. However, the emergence of resistance to the most common antifungal drugs, also due to biofilm formation, there is an increasing need to design new and more effective antifungals with less toxic. Sulfonyl hydrazones are well-known for their pharmacological effects, such as antifungal and antibacterial potential and can act as an antinociceptive, antidepressant, antineoplastic activity. The aim of this study was to investigate the anti-candidal and anti-biofilm activity o ...Daha fazlası