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Bulunan: 13 Adet 0.003 sn
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Bulunan: 13 Adet 0.003 sn
İlgili Araştırmacılar [20]
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Atıf Dizini [3]
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Yayın Dili [2]
Süresiz Ambargo

Identification of medically important yeasts by sequence analysis of the internal transcribed spacer and D1/D2 region of the large ribosomal subunit

AYDIN, Merve | KUŞTİMUR, Semra | KALKANCI, Ayşe | DURAN, Tuğçe

Background: The prevalence of opportunistic yeast infections has increased in recent decades as the resultof an increasing immunocompromised patient population.Aims: To evaluate ribosomal RNA (rRNA) gene sequence to identify medically important yeast species, toinvestigate the performance of both the rRNA gene internal transcribed spacer (ITS) and D1/D2 region in identifying clinically relevant yeasts, and to compare these results with those of a standard phenotypicmethod.Methods: Both regions from 50 yeast strains, comprising 45 clinical isolates and 5 reference strains, wereamplified using P ...Daha fazlası

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Molecular characterization and subtyping of Blastocystis in urticarial patients in Turkey

AYDIN, Merve | YAZICI, Mustafa | DEMİRKAZIK, Mehtap | KOLTAŞ, İsmail Soner | ÇIKMAN, Aytekin | GÜLHAN, Barış | DURAN, Tuğçe | YILMAZ, Aysun | KARA, Murat

Objective: To investigate Blastocystis’ etiologic role and association with gastrointestinal symptomatology in acute and chronic urticaria patients and to identify Blastocystis subtypes responsible for urticaria. Methods: The study included urticaria patients and healthy individuals that presented to our polyclinic between June 2015 and May 2017. The participants were assigned into Group I (137 patients), subdivided into acute (72) and chronic urticaria patients (65), and Group II (129 control individuals). Blastocystis presence was investigated by native-Lugol examination, trichrome staining, ...Daha fazlası

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Absence of the mecC gene in methicillin-resistant Staphylococcusaureus isolated from various clinical samples: The first multi-centeredstudy in Turkey

ÇIKMAN, Aytekin | AYDIN, Merve | GÜLHAN, Barış | KARAKEÇİLİ, Faruk | KURTOĞLU, Muhammet Güzel | YÜKSEKKAYA, Şerife | PARLAK, Mehmet | GÜLTEPE, Sümbül Bilge | ÇOPUR ÇİÇEK, Ayşegül | BAYINDIR BİLMAN, Fulya | ÇİFTÇİ, İhsan Hakkı | KARA, Murat | ATMACA, Selahattin | ÖZEKİNCİ, Tuncer

tBackground: mecA is a predefined gene causing methicillin resistance in Staphylococcus aureus (S. aureus)isolates; however, it has been shown that some methicillin-resistant S. aureus (MRSA) strains do notcarry this gene. Recently, in isolates found to be MRSA-positive but mecA-negative, a new resistance gene called mecC, which is a homolog of mecA, has been reported. This study aimed to investigate the mecCand mecA genes in MRSA strains isolated from different geographic regions in Turkey.Methods: The sample of the study consisted of 494 MRSA strains isolated from seven geographical regionsi ...Daha fazlası

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Mikobakteriler

SARIBAŞ, Suat | AYDIN, Merve

Mycobacterium cinsi, tümünün aside dirençli boyanma özelliği gösterdiği gram-pozitif basil türlerini içerir. Önemli bir tür olan Mycobacterium tuberculosis (MTB), Dickens zamanında tüketici, korkunç bir hastalık olarak nitelendirilen tüberküloz (verem) etkenidir. Çoğu zengin ülkeler dışında olmak üzere, tüberküloz, dünya nüfusunun hâlâ üçte birini enfekte etmekte ve her yıl yaklaşık 2 milyon kişinin ölümüne neden olmaktadır. Mycobacterium leprae, eski ve şekil bozucu bir hastalık olan lepra (cüzzam) etkenidir. Daha az patojenik olan çok sayıda tür ise, başta AIDS olmak üzere immün yetmezliği o ...Daha fazlası

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Borrelia burgdorferi chemotaxis toward tick protein Salp12 contributes to acquisition

MURFIN, Kristen E. | KELINBARD, Ruby | AYDIN, Merve | SALAZAR, Samuel A. | FIKRIG, Erol

Lyme disease is a common tick-borne infection caused by the spirochete Borrelia burgdorferi sensu stricto (s.s.). B. burgdorferi s.s. may utilize chemotaxis, the directional migration towards or away from a chemical stimulus, for transmission, acquisition, and infection. However, the specific signals recognized by the spirochete for these events have not been defined. In this study, we identify an Ixodes scapularis salivary gland protein, Salp12, that is a chemoattractant for the spirochete. We demonstrate that Salp12 is expressed in the I. scapularis salivary glands and midgut and expression ...Daha fazlası

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In vitro anti-candidal and anti-biofilm activity of new ethane sulfonyl hydrazone compound

ÖZTÜRK, Ali | AYDIN, Merve | ÖZDEMİR ÖZMEN, Ümmühan

Candida species cause cutaneous and systemic infections with a high mortality rate, especially in immunocompromised patients. However, the emergence of resistance to the most common antifungal drugs, also due to biofilm formation, there is an increasing need to design new and more effective antifungals with less toxic. Sulfonyl hydrazones are well-known for their pharmacological effects, such as antifungal and antibacterial potential and can act as an antinociceptive, antidepressant, antineoplastic activity. The aim of this study was to investigate the anti-candidal and anti-biofilm activity o ...Daha fazlası

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The evaluation of oxidative stress parameters in the benign prostatic hyperplasia, prostatitis and prostate cancer

BOZKURT, Aliseydi | GÜRSUL, Cebrail | AYDIN, Merve | SAYAR, İlyas | KARABAKAN, Mehmet | ÇIKMAN, Aytekin

Aim: Recently, oxidative stress has been well known that it has especially important a role in benign prostatic hyperplasia, prostatitis, and prostate cancer. The present study has planned to estimate parameters of the oxidative stress and the antioxidant status in patients with benign prostatic hyperplasia, prostatitis and prostate cancer. Material and Method: For this aim totally fourty men with benign prostatic hyperplasia (n=14), prostatitis (n=15) and prostate cancer (n=11) without any other chronic disease, and who not use cigarettes and alcohol were subjected. Venous blood samples were ...Daha fazlası

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Bruselloz Hastalarında Asimetrik Dimetilarjinin (ADMA) Düzeylerinin Araştırılması

SEZGİN, Muhammed | AYDIN, Merve | KARAKEÇİLİ, Faruk | ÇIKMAN, Aytekin | GÜLHAN, Barış | ARSLAN, Yusuf Kemal

Amaç: Asimetrik dimetilarginin (ADMA), nitrik oksit sentazın (NOS) ana endojen inhibitörüdür. NOS, konak savunmasında ve vasküler yapının sürdürülmesinde önemli rol oynamaktadır. Yüksek ADMA düzeylerinin endoteldis fonksiyonu ile ilişkili olduğu ve çeşitli hastalıklarda rol aldığı gösterilmiştir. Brucellaspp.’nin neden olduğu zoonoz bir hastalık olan bruselloz, vaskülopati olarak kendini gösterebilmektedir. Ancak, bruselloz ile ADMA arasındaki ilişki ile ilgili yeterli veri bulunmamaktadır. Çalışmamızın amacı bruselloz hastalarında ve kontrol grubunda ADMA düzeyinin araştırılmasıdır. Yöntemler ...Daha fazlası

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Could interleukin-33 and its suppressor of tumorigenicity 2 (ST2) receptor have a role in cervical human papillomavirus (HPV) infections?

KULHAN, Nur Gözde | KULHAN, Mehmet | AYDIN, Merve | NAYKİ, Ümit | NAYKİ, Cenk | ULUĞ, Paşa | ATA, Nahit | MERTOĞLU, Cuma | ÇIKMAN, Aytekin | SAYAR, İlyas | TÜRKLER, Can

Why most women can clear human papillomavirus (HPV) infections while others can develop permanent infections. The stimulation of immunotolerance of the immune system of the host by the persistent HPV infection may be the answer to this question. Interleukin-33 (IL-33) may play a role in the pathogenesis of HPV infection, this hypothesis was thought to be due to the rapid release of IL-33 from damaged cells following tissue damage, necrosis, and activation of the inflammasome. Thus, in this study, the role of IL33/suppressor of tumorigenicity 2 (ST2) was emphasized in HPV positive and HPV negat ...Daha fazlası

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Evaluation of epidemiological, clinical, and laboratory characteristics and mortality rate of patients with Crimean-Congo hemorrhagic fever in the northeast region of Turkey

KARAKEÇİLİ, Faruk | ÇIKMAN, Aytekin | AYDIN, Merve | BİNAY, Umut Devrim | KESİK, Ozan Arif | ÖZÇİÇEK, Fatih

ackground & objectives : Crimean-Congo hemorrhagic fever (CCHF), an illness characterized by fever and hemorrhage, is caused by a CCHF virus (CCHFV). It is an important public health problem in Turkey. The objective of this study was to evaluate the demographic, clinical, and laboratory characteristics and mortality rates of CCHF patients in the northeast region of Turkey. Methods : A total of 206 patients, diagnosed with CCHF, from northeast region of Turkey were included and evaluated between 2011 and 2017. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) and immunofluoresc ...Daha fazlası

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Kimyasal Dezenfeksiyon

ÇOPUR ÇİÇEK, Ayşegül | SIĞ, Ali Korhan | AYDINLI, Aydın | KAYAR DOĞAN, Esra | BAŞUSTAOĞLU, Ahmet | İNCE, Gizem | AYDIN, Merve | DOLU, Nazan | ALTUNKAYNAK ÇAMCA, Hande Özge

Kimyasal biyosidler, mikroorganizmaları inhibe veya inaktive etme özellikleri nedeniyle çeşitli uygulamalarda kullanılırlar. Bu bölümde biyosidler, alkoller, aldehitler, antimikrobiyal metaller ve halojenler dahil olmak üzere, genel kimyasal yapılarına göre sınıflandırılmıştır. Her bir ana kimyasal grup için temel biyosid tipleri tanımlanmış ve bunların uygulamaları, etki spektrumları, avantajları, dezavantajları ve bilinen etki mekanizmaları tartışılmıştır. Biyosidlerin etki mekanizmaları bölüm 7’de, bazı kimyasal biyosidlerin sterilizasyon işlemlerindeki özel kullanımları ise bölüm 6’da ele ...Daha fazlası

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Effects of melatonin treatment on the spermatogenesis and serum inflammatory cytokine levels in diabetic rats

BOZKURT, Ali Seydi | KARABAKAN, Mehmet | AYDIN, Merve | GÜMÜŞTAŞ, Sinem | ONK, Didem | GÜRSUL, Cebrail | EROL, Hüseyin Serkan

Aim: Diabetes mellitus (DM) is known to have side effects on sexual and reproductive functions in males. The aim of current study was to investigate the effect of melatonin treatment on spermatogenesis and serum inflammatory cytokine levels in diabetic rats. Material and Method: Eighteen adult Wistar albino male rats were divided randomly into three groups each containing 6 rats; control group (group 1), diabetic group (group 2), diabetic treated with melatonin group (group 3). Experimental diabetes was obtained by administrating 50 mg/kg streptozotocin. Melatonin treatment was administered in ...Daha fazlası

6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve cerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

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